A5030183849- Axon Guidance and Neuronal Signaling
- Retinal Diseases and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Retinal Development and Disorders
- Retinal Imaging and Analysis
- Neuroscience and Neuropharmacology Research
- Hippo pathway signaling and YAP/TAZ
- Wnt/β-catenin signaling in development and cancer
- Angiogenesis and VEGF in Cancer
- Developmental Biology and Gene Regulation
- Nuclear Receptors and Signaling
- Sulfur Compounds in Biology
- Atherosclerosis and Cardiovascular Diseases
- Cellular Mechanics and Interactions
- Retinoids in leukemia and cellular processes
Retina Foundation of the Southwest
2013-2025
The University of Texas Southwestern Medical Center
2007-2016
Foundation Center
2013
The adult brain maintains two regions of neurogenesis from which new neurons are born, migrate to their appropriate location, and become incorporated into the circuitry CNS. One these, subgranular zone hippocampal dentate gyrus, is primary interest because role this region in learning memory. We show that mice lacking EphB1, more profoundly EphB1 EphB2, have significantly fewer neural progenitors hippocampus. Furthermore, other aspects neurogenesis, such as polarity, cell positioning,...
The integration of newborn neurons into functional neuronal networks requires migration cells to their final position in the developing brain, growth and arborization processes formation synaptic contacts with other neurons. A central player among signals that coordinate this complex sequence differentiation events is secreted glycoprotein Reelin, which also modulates plasticity, learning memory adult brain. Binding Reelin ApoER2 VLDL receptor, two members LDL receptor family, initiates a...
Age-related macular degeneration (AMD) is a leading cause of vision loss, driven by retinal pigment epithelium (RPE) and photoreceptor degeneration. A key feature drusen accumulation between the RPE Bruch's membrane. In intermediate AMD, hyperreflective foci (HRF)-bright intraretinal lesions visible on optical coherence tomography (OCT) imaging-serve as biomarkers disease progression. To study HRF mechanisms, we generated induced pluripotent stem cell (iPSC) lines from an AMD patient with...
The dentate gyrus (DG) is one of two areas in the mature brain where stem cells reside to continuously produce new neurons throughout adulthood. While much research has focused on DG for its roles adult neurogenesis, little known regarding how this key region initially develops form distinct architecture. We show here that murine EphB2 receptor tyrosine kinase critical embryonic/postnatal development a specific as lateral suprapyramidal blade (LSB). Intracellular truncation and point mutants...
Age-related macular degeneration (AMD) is one of the major causes vision loss in elderly most developed countries. Among other causes, oxidative stress retinal pigment epithelium (RPE) has been hypothesized to be a driving force AMD pathology. Oxidative could treated by antioxidant administration into RPE cells. However, achieve high in-vivo efficacy an antioxidant, it imperative that agent able penetrate tissues and Evidence suggests lipophilicity governs cellular penetrance. Out many...
Abstract Age‐related macular degeneration (AMD) is associated with formation of drusen, clusters lipids, and oxidized lipid products under the retinal pigment epithelium (RPE). 7‐Ketocholesterol (7KC) a form cholesterol present in drusen hypothesized to play role AMD pathogenesis. The association 7KC cellular toxicity inflammation, key elements pathology, has been demonstrated. However, effects on altering RPE bioenergetics, potentially important pathologic process AMD, are unclear. Herein,...
Background/objective A subset of neovascular age-related macular degeneration (nvAMD) subjects appears to be refractory the effects anti-VEGF treatment and require frequent intravitreal injections. The vascular phenotype choroidal (CNV) lesions may contribute resistance. Animal studies CNV have shown that cells originating from bone marrow are capable forming varying cell types in lesions. This raised possibility a similar population human nvAMD subjects. Materials methods Blood draws were...
This study investigated the effects of esterification and increased lipophilicity on cellular penetration, accumulation retention in ARPE-19-nic cells using ester functionalized rhodamine B dyes.Rhodamine was esterified to generate four dyes with increasing lipophilicity. Cellular uptake, mitochondrial localization were vitro direct intracellular extracellular fluorescence quantitation, confocal high-resolution live cell imaging co-localization Mito-GFP.Cellular penetrance, accumulation,...