A5073824069- Parkinson's Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- Nerve injury and regeneration
- Ion channel regulation and function
- Neurological disorders and treatments
- RNA regulation and disease
- biodegradable polymer synthesis and properties
- Calcium signaling and nucleotide metabolism
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Biochemical Analysis and Sensing Techniques
- Gastrointestinal motility and disorders
- Neurological diseases and metabolism
- Muscle Physiology and Disorders
- Botulinum Toxin and Related Neurological Disorders
- Erythrocyte Function and Pathophysiology
- Connexins and lens biology
Sangji University
2020-2025
Background: Parkinson’s disease (PD) is a neurodegenerative disorder that characterized by substantial loss of dopaminergic cells in the substantia nigra (SN) and formation intracellular Lewy bodies, which are mainly composed α-synuclein (α-syn). Acupuncture has been used to improve symptoms PD humans exhibits neuroprotective effect against Parkinsonism animal models. We further investigated acupuncture via its on α-syn levels, cell death serping1 expression...
Patients with Parkinson's disease (PD) have gastrointestinal motility disorders, which are common non-motor symptoms. However, the reasons for these disorders remain unclear. Increased alpha-synuclein (α-syn) is considered an important factor in peristalsis dysfunction colonic smooth muscles patients PD. In this study, morphological changes and association between serping1 α-syn were investigated colon of 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine-induced chronic PD model. noted model,...
Our understanding of the gastrointestinal system in pathophysiology Parkinson's disease (PD) has grown considerably over last two decades. Patients with PD experience notable symptoms, including constipation. In this study, effects knocked-down serping1, associated contraction and relaxation smooth muscle inflammation responses, by applying serping1 siRNA were investigated 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine-induced mice an α-syn change aspect. result, expression was knocked down...
Parkinson's disease (PD) is a globally common progressive neurodegenerative resulting from the loss of dopaminergic neurons in brain. Increased α-synuclein (α-syn) associated with degeneration and non-motor symptoms like gastrointestinal disorders. In this study, we investigated association between serum/glucocorticoid-related kinase 1 (SGK1) α-syn colon PD mouse model. SGK1 expression patterns were opposite surrounding tissue, decreased increased group. Immunofluorescence analyses revealed...
We investigated the potential association between integrin α7 (ITGA7) and alpha-synuclein (α-syn) in a methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) mouse model. Tyrosine hydroxylase (TH), ITGA7, α-syn expression substantia nigra (SN) of brain were observed to examine pathological characteristics PD. To determine relationship ITGA7 PD, TH was after siRNA knockdown SH-SY5Y cells. The microarray signal decreased SN MPTP group, indicating reduced...
Parkinson's disease (PD) is characterized by a loss of dopaminergic cells in the substantia nigra, and its histopathological features include presence fibrillar aggregates α-synuclein (α-syn), which are called Lewy bodies neurites. pathology has been identified not only brain but also various tissues, including muscles. This study aimed to investigate link between serine/arginine-rich protein specific kinase 3 (
Abstract Background Parkinson’s disease (PD) represent a loss of dopaminergic neurons in the substantia nigra (SN) midbrain. However, its cause remains unknown and Triadin (TRDN) function brain is also unknown. To examine relationship between TRDN PD, expression levels protein related to PD knockdown status were studied SH-SY5Y cells. Cell viability apoptosis assessed effect on cells by decreased TRDN, proteins confirmed. Results This study confirmed level (P < 0.005) at SN...
Parkinson’s disease (PD), caused by destruction of dopaminergic neurons in the brain, leads to motor symptoms like bradykinesia, tremor, and walking impairments. While most research effort focuses on changes neuronal pathology we examined how muscle proteins were altered a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model PD. A Ca 2+ release channel complex, consisting ryanodine receptors (RYR), triadin (TRDN), calsequestrin (CSQ1), is important for excitation-contraction...
Abstract Parkinson’s disease (PD) is known as the second most common neurodegenerative disease, which caused by destruction of dopaminergic neurons in substantia nigra (SN) brain; however, reason for death remains unclear. An increase α-synuclein (α-syn) considered an important factor pathogenesis PD. In current study, we investigated association between PD and serine/arginine-rich protein specific kinase 3 (Srpk3) MPTP-induced parkinsonism mice model SH-SY5Y cells treated with MPP+. Srpk3...