Cellular and molecular approaches are being explored to find a biomarker which can predict the development of radiation induced acute toxicity prior therapy. SNPs in responsive genes may be considered as an approach develop tools for finding inherited basis clinical radiosensitivity. The current study attempts screen single nucleotide polymorphisms/deletions DNA damage response, repair, profibrotic cytokine well antioxidant response its predictive potential with normal tissue adverse...

<ns3:p>Background Cervical cancer poses a significant public health challenge, particularly in low and middle-income countries. Despite advancements treatment, the disease remains leading cause of cancer-related deaths among women globally. Chemoradiation utilizing cisplatin has been cornerstone therapy for locally advanced cervical cancer. Prognostic biomarkers, including hematological parameters, have emerged as valuable tools guiding treatment decisions predicting outcomes. Methodology...

<ns4:p>Background/Aim To examine the clinical correlation of p16 expression with Epithelial–Mesenchymal Transition (EMT) markers and lymphatic invasion in OPSCC patients terms status at presentation, subsequent progression, survival. Methods Tissue blocks biopsy-proven Oropharyngeal Squamous Cell Carcinoma were subjected to Immunohistochemistry (IHC) for evaluating p16, e-cadherin, vimentin podoplanin. This pattern was correlated demographic details, treatment response survival patterns....

<ns3:p>Background Head and neck cancer (HNCs) is a major health issue worldwide, India has contributed to approximately 2.4 lakh new cases in 2022. Definitive chemoradiation the standard treatment for locally advanced disease but carries risk of lower respiratory tract infections (LRTI) that add morbidity, hospitalization, cost, possible delay treatment. The increasing incidence antimicrobial resistance (AMR) also management burden. This study aimed assess microbiological profiles patterns...

<ns3:p>Background Cervical cancer poses a significant public health challenge, particularly in low and middle-income countries. Despite advancements treatment, the disease remains leading cause of cancer-related deaths among women globally. Chemoradiation utilizing cisplatin has been cornerstone therapy for locally advanced cervical cancer. Prognostic biomarkers, including hematological parameters, have emerged as valuable tools guiding treatment decisions predicting outcomes. Methodology...

Oral health awareness and oral care are crucial aspects of oncology nursing practice. However, very few studies concentrate on the cancer patients undergoing treatment practice in Indian subcontinent scenario/situation. Most published have been conducted Western European countries.This study aimed to determine nurses' barriers regarding chemotherapy radiation therapy.A cross-sectional descriptive survey was among 158 staff nurses working oncology-related areas from four different hospitals...

The purpose of this study is to describe a randomized control trial protocol that assesses the effectiveness an oral care on chemotherapy- and radiation therapy-induced complications in cancer patients.This randomized, outcome assessor blinded study. For Phase I training phase, one group pretest-posttest design will be implemented for staff nurses patients II Intervention Phase, clinical used determine protocol. Twenty-five working oncology areas hospital trained about patients. Seventy...

There has been growing interest in the use of epidermal growth factor receptor inhibitors various cancers. The study was conducted to evaluate efficacy and safety gefitinib as a monotherapy patients with recurrent or metastatic cervical cancer. Patients carcinoma who experienced locoregional recurrence distant metastases either at presentation after definitive combined chemoradiotherapy postoperative radiotherapy were enrolled. Gefitinib administered orally dose 250 mg/d eligible patients....

This study presents the dosimetric data taken with radiochromic EBT3 film brass mesh bolus using solid water and semi-breast phantoms, its clinical implementation to analyze surface dose estimates chest wall in postmastectomy radiotherapy (PMRT) patients.Water-equivalent thickness of was estimated phantom under 6 megavoltage photon beam. Following measurements were no bolus, 1, 2, 3 layers bolus: (a) doses on normal incidence curved a locally fabricated cylindrical for tangential field...

Aims and Objectives: To report the results of treatment with intraluminal brachytherapy (ILRT) after concurrent chemoradiotherapy for esophageal carcinoma respect to disease free survival (DFS), dysphagia interval (DFI), complications treatment. Materials Methods: The study retrospectively analyzed records 26 eligible patients nonmetastatic esophagus treated definitive followed by ILRT between 2008 2011. DFS DFI were estimated factors likely influence them analyzed. Results: Nineteen (73%)...

In some situations of radiotherapy treatments requiring application tissue-equivalent bolus material (e.g., gel bolus), due to material's rigid/semi-rigid nature, undesirable air gaps may occur beneath it because irregularity body surface. The purpose this study was evaluate the dosimetric parameters such as surface dose (Ds), depth maximum (dmax), and along central axis derived from percentage (PDD) curve a 6 MV clinical photon beam in presence between treatment surface.A holder designed...

Abstract Domperidone, ondansetron and olanzapine can prolong the QT interval. The clinical use of combinations these drugs is not uncommon. Our study aimed to determine presence any QTc prolonging effect combination when used as antiemetic in patients receiving cancer chemotherapy. We carried out a prospective, observational with malignancy who were receive domperidone, olanzapine-containing regimen. Electrocardiograms recorded before during administration antiemetics, for three consecutive...

To assess and compare the local control toxicities between HDR Intracavitary Brachytherapy with 7.5 Gy 9 per fraction after EBRT in treatment of carcinoma cervix.A total 180 patients were randomly assigned to 2 arms. Arm A received intracavitary brachytherapy a dose fraction, 1 week for 3 fractions B fractions. Patients evaluated on follow up assessment toxicities.The median was 12 months (6-18 months). In arm 89% patient had complete response 11% recurrence or metastasis. 93% 7% Grade 2/3...

Objective. This study evaluated the effect of voice intervention in patients who received chemoradiation to neck for non-laryngeal head and malignancies. Methods. Twenty individuals with malignancies were divided by block randomisation into an group that rehabilitation a control without rehabilitation. All underwent acoustic analysis, perceptual subjective analysis before commencement chemoradiotherapy at 1, 3 6 months after chemoradiotherapy.Results. In both groups, all parameters...

A tissue-equivalent bolus of sufficient thickness is used to overcome build up effect the chest wall region postmastectomy radiotherapy (PMRT) patients with tangential technique till Radiation Therapy Oncology Group (RTOG) Grade 2 (dry desquamation) skin reaction observed. The aim this study optimize surface dose delivered in three-dimensional using EBT3 film.Measurements were conducted calibrated films thorax phantom under "open beam, Superflab gel (0.5 cm) and brass conditions check...

Lung is the most common site of small cell carcinoma (SCLC) - a poorly differentiated neuroendocrine (PDNEC). SCLC comprises 15-20% invasive cancers lung.This study was conducted to appraise accuracy and pitfalls diagnosis PDNEC on cytology along with treatment responses if available.Retrospective for 2 years yielded 21 cases cytology.Slides fine-needle aspiration lymph nodes, tumor, bronchial brush, bronchoalveolar lavage specimens were used. The histological correlation obtained as...

This study presents a method to estimate midplane dose (Diso, transit) in vivo from transit signal (St) measured with thimble ionization chamber cancer of the middle-third esophagus patients treated three-dimensional radiotherapy (RT). detector is positioned at level electronic portal imaging device gantry medical linear accelerator.Efficacy inhomogeneity corrections three calculation algorithms available XiO treatment planning system (TPS) for planned (for open fields) TPS) was studied...

Transmission of radiation fluence through patient's body has a correlation to the planned target dose. A method estimate delivered dose volumes was standardized using beam level 0.6 cc ionization chamber (IC) positioned at electronic portal imaging device (EPID) plane from measured transit signal (S _t ) in patients with cancer uterine cervix treated three-dimensional conformal radiotherapy (3DCRT). The IC buildup cap mounted on linear accelerator EPID frame fixed source distance...

<title>Abstract</title> Background Head and neck cancer patients receiving chemotherapy radiation therapy may experience a notable frequently sudden decline in their oral health. These alterations include mucositis that develops during shortly after treatment, candida infections, trouble speaking, difficulty eating, bleeding gums, tissue fibrosis. Materials Methods The study aimed to determine the effectiveness of care protocol intervention on health complications. were observed every week...

Background High dose rate (HDR) image-guided brachytherapy with Cobalt-60 isotope is a relatively recent approach. The aim of the study to evaluate clinical and dosimetric parameters in terms tumour response, bladder, rectal toxicity patients undergoing Co-60 HDR brachytherapy. Materials Method All were initially treated chemoradiation (CT-RT) at our center or other referral centers external beam radiation therapy (EBRT) for 45 Gy–60 Gy 1.8-2Gy/fraction (including nodal boost) concomitant...

Cervical carcinoma is the second commonest malignancy among females worldwide. In India, about 365.71 million women aged over 15 years are more vulnerable to cervical carcinoma. Risk factors may include immunodeficiency diseases, herpes, smoking and oral contraceptives. Scientific literature has documented that type 2 diabetes mellitus (T2DM) could aggravate risk of some malignancies (hepatic, pancreatic, endometrial). This study aimed evaluate potential association between in women.