A5075086109- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Animal Behavior and Reproduction
- Retinal Development and Disorders
- Advanced Memory and Neural Computing
- Plant and animal studies
- Plant and Biological Electrophysiology Studies
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Gene Regulatory Network Analysis
- Cellular transport and secretion
- Plant Molecular Biology Research
- Endoplasmic Reticulum Stress and Disease
- Glaucoma and retinal disorders
- Physiological and biochemical adaptations
- Extracellular vesicles in disease
- Zebrafish Biomedical Research Applications
- Genomics and Chromatin Dynamics
- Ocular Oncology and Treatments
University of California, Los Angeles
2023-2024
Howard Hughes Medical Institute
2023-2024
University of Virginia
2015-2020
Abstract To survive, animals must convert sensory information into appropriate behaviours 1,2 . Vision is a common sense for locating ethologically relevant stimuli and guiding motor responses 3–5 How circuitry converts object location in retinal coordinates to movement direction body remains largely unknown. Here we show through behaviour, physiology, anatomy connectomics Drosophila that visuomotor transformation occurs by conversion of topographic maps formed the dendrites...
Highlights•Cooperative feeding groups emerge among fruit fly larvae•Cooperation requires visually guided inter-larval coordinated movements•Stable membership in cooperative experienceSummarySpectacular examples of behavior a variety animals and may serve critical roles fitness [1, 2]. However, the rules governing such have been difficult to elucidate [2]. Drosophila larvae are known socially aggregate [3, 4] use vision, mechanosensation, gustation recognize each other [5–8]. We describe here...
Advances in brain connectomics have demonstrated the extraordinary complexity of neural circuits.1,2,3,4,5 Developing neurons encounter axons and dendrites many different neuron types form synapses with only a subset them. During circuit assembly, express cell-type-specific repertoires comprising cell adhesion molecules (CAMs) that can mediate interactions between developing neurites.6,7,8 Many CAM families been shown to contribute wiring ways.9,10 It has challenging, however, identify...
Abstract Converting sensory information into motor commands is fundamental to most of our actions 1,2 . In Drosophila , visuomotor transformations are mediated by Visual Projection Neurons (VPNs) 3,4 These neurons encode object location and motion drive directional behaviors through a synaptic gradient mechanism 5 However, the molecular origins such graded connectivity remain unknown. We addressed this question in VPN cell type called LPLC2 6 which integrates looming transforms it an escape...
Abstract Cooperative behavior can confer advantages to animals. This is especially true for cooperative foraging which provides fitness benefits through more efficient acquisition and consumption of food. While examples group have been widely described, the principles governing formation such aggregations rules that determine membership remain poorly understood. Here, we take advantage an experimental model system featuring in Drosophila . Under crowded conditions, fly larvae form...
Summary How do developing neurons select their synaptic partners? To identify molecules matching partners, we integrated the synapse-level connectome of neural circuits with developmental expression patterns and binding specificities cell adhesion (CAMs) on pre- postsynaptic neurons. We focused parallel pathways in Drosophila visual system, which closely related form synapses onto target show that choice partners correlates receptor-ligand pairs Beat Side proteins immunoglobulin superfamily...
The brain exhibits remarkable neuronal diversity which is critical for its functional integrity. From the sheer number of cell types emerging from extensive transcriptional, morphological, and connectome datasets, question arises how capable generating so many unique identities. 'Terminal selectors' are transcription factors hypothesized to determine final identity characteristics in post-mitotic cells. Which function as terminal selectors level control they exert over different not well...
The Drosophila Melanogaster (fruit fly) nervous system serves as a highly convenient model for investigating the underpinnings of diverse biological processes at molecular, cellular, and circuit levels. Advances in molecular genetics, conjunction with state-of-the-art imaging techniques, now enable integration profiles individual neurons their physiological morphological properties. This facilitates comprehensive understanding system, bridging gap between development, structure, function....
Summary Cooperative behavior can confer advantages to animals. This is especially true for cooperative foraging which provides fitness benefits through more efficient acquisition and consumption of food. While examples group have been widely described, the principles governing formation such aggregations rules that determine membership remain poorly understood. Here we take advantage an experimental model system featuring in Drosophila . Under crowded conditions, fly larvae form coordinated...