A5074017904- Neurobiology and Insect Physiology Research
- Circadian rhythm and melatonin
- Animal Behavior and Reproduction
- Insect and Arachnid Ecology and Behavior
- Liver Diseases and Immunity
- Memory and Neural Mechanisms
- Sleep and related disorders
- Insect Resistance and Genetics
- Photoreceptor and optogenetics research
- Sleep and Wakefulness Research
- Plant and Biological Electrophysiology Studies
- Insect behavior and control techniques
- Sleep and Work-Related Fatigue
- Insect-Plant Interactions and Control
- Gastroesophageal reflux and treatments
- Zebrafish Biomedical Research Applications
- Diptera species taxonomy and behavior
- Mosquito-borne diseases and control
- Health and Medical Studies
- Liver Disease Diagnosis and Treatment
- Retinal Development and Disorders
- Plant and animal studies
- Physiological and biochemical adaptations
- Spaceflight effects on biology
- Genetics, Aging, and Longevity in Model Organisms
University of California, Los Angeles
2022-2023
University of Padua
2016-2022
Université Paris-Saclay
2022
Institut des Neurosciences Paris-Saclay
2022
Centre National de la Recherche Scientifique
2022
Individuals vary in how their circadian system synchronizes with the cyclic environment (zeitgeber). Assessing these differences “phase of entrainment”—often referred to as chronotype—is an important procedure laboratory experiments and epidemiological studies but is also increasingly applied medicine, both diagnosis therapy. While biochemical measurements (e.g., dim-light melatonin onset [DLMO]) internal time are still gold standard, they laborious, expensive, mostly rely on special...
Tracking visual objects while maintaining stable gaze is complicated by the different computational requirements for figure-ground discrimination, and distinct behaviors that these computations coordinate. Drosophila melanogaster uses smooth optomotor head body movements to stabilize gaze, impulsive saccades pursue elongated vertical bars. Directionally selective motion detectors T4 T5 cells provide inputs large-field neurons in lobula plate, which control stabilization behavior. Here, we...
Patients with Primary Biliary Cholangitis (PBC) exhibit delayed sleep-wake habits, disturbed night sleep and daytime sleepiness/fatigue. Such combination of symptoms is reminiscent phase disorder (DSPD), which benefits from morning light treatment. The aim the present pilot study was to test effect treatment in a group 13 well-characterized patients PBC [all females; (mean ± SD) 53±10 yrs]. Six healthy individuals (4 females, 57±14 yrs) 7 cirrhosis (1 female, 57±12 served as controls disease...
Abstract Converting sensory information into motor commands is fundamental to most of our actions 1,2 . In Drosophila , visuomotor transformations are mediated by Visual Projection Neurons (VPNs) 3,4 These neurons encode object location and motion drive directional behaviors through a synaptic gradient mechanism 5 However, the molecular origins such graded connectivity remain unknown. We addressed this question in VPN cell type called LPLC2 6 which integrates looming transforms it an escape...
Daylight saving time (DST) is a source of circadian disruption impinging on millions people every year. Our aim was to assess modifications, if any, in the number, type, and outcome Accident & Emergency (A&E) visits/return visits over DST months. The study included 366,527 84,380 return A&E Padova hospital (Northern Italy) 3 periods between years 2007 2016: period 1 (2 weeks prior 19 after), 2 “winter time” 4 (5 consecutive non-DST weeks). For each visit/return visit, information...
ABSTRACT During recent decades, model organisms such as Drosophila melanogaster have made it possible to study the effects of different environmental oxygen conditions on lifespan and oxidative stress. However, many studies often yielded controversial results usually assigned variations in genetic background differences design. In this study, we compared longevity ROS levels young, unmated males three laboratory wild-type lines (Canton-S, Oregon-R Berlin-K) one mutant line (Sod1n1) a...
The central complex (CX) is a neural structure located on the midline of insect brain that has been widely studied in last few years. Its role navigation and goal-oriented behaviors resembles those played by basal ganglia mammals. However, mechanisms neurotransmitters involved these processes remain unclear. Here, we exploited an vivo bioluminescence Ca2+ imaging technique to record activity targeted neurons ellipsoid body (EB). We used different drugs evoke excitatory Ca2+-responses,...
The mechanism of action selection is a widely shared fundamental process required by animals to interact with the environment and adapt it. A key step in this filtering "distracting" sensory inputs that may disturb selection. Because it has been suggested that, principle, also be processed circuits vertebrate invertebrates, we wondered whether invertebrates show ability filter out stimuli during goal-directed action, as seen vertebrates. In experiment, was studied wild-type Drosophila...
Abstract Animals use pain-relief learning to discern which actions can diminish or abolish noxious stimuli. If relief from pain is provided in a specific location, place the mechanism used pinpoint that location space. Little known about how physiological and non-directly damaging stimuli alter visual-based searching behaviour animals. Here we show optogenetically-induced activation of bitter-sensing neurons urges Drosophila melanogaster seek bitter taste stimulation this distressful, but...
In humans, memory consolidation can be aided by the representation of an odor previously associated with target information during sleep. elegant study, Zwaka et al. (Curr Biol 25: 2869-2874, 2015) have demonstrated that same process occurs in honeybees, suggesting relationship between sleep and may similar across different animal species.
ABSTRACT In the last few years several studies have investigated neural mechanisms underlying spatial orientation in Drosophila melanogaster . Convergent results suggest that this mechanism is associated with specific circuits located within Central Complex (CC). Furthermore such appear to be visual attention, specifically selective attention processes implicated control of action. Our aim was understand how wild-type flies react abrupt appearance a distractor during an ongoing locomotor...
Abstract Tracking visual objects while stabilizing the background is complicated by different computational requirements for object tracking and motion vision. In fruit fly, directionally selective detectors T4 T5 cells supply wide-field neurons of lobula plate, which control smooth gaze stabilization behavior. Here, we hypothesized that an anatomically parallel pathway supplied T3, encodes small moving innervates lobula, drives body saccades toward objects. We combined physiological...