A5018342626- Cutaneous lymphoproliferative disorders research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Lymphoma Diagnosis and Treatment
- Metal complexes synthesis and properties
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Nail Diseases and Treatments
- CAR-T cell therapy research
- Glycosylation and Glycoproteins Research
- Crystal structures of chemical compounds
- Crystallography and molecular interactions
- Dermatologic Treatments and Research
- Autoimmune Bullous Skin Diseases
- Eosinophilic Disorders and Syndromes
- Monoclonal and Polyclonal Antibodies Research
- T-cell and Retrovirus Studies
- Lanthanide and Transition Metal Complexes
- Diversity and Career in Medicine
- Retinoids in leukemia and cellular processes
- Earth Systems and Cosmic Evolution
- Environmental, Ecological, and Cultural Studies
- Skin Protection and Aging
- Organ Donation and Transplantation
- Biochemical and Structural Characterization
University of North Carolina at Chapel Hill
2015-2024
UNC Lineberger Comprehensive Cancer Center
2024
American Academy of Dermatology
2015
William & Mary
2002-2014
Duke Medical Center
2009-2012
Duke University Hospital
2009-2012
Howard Hughes Medical Institute
2007
National Institute of Mental Health
2007
National Institutes of Health
2007
Williams (United States)
2002-2004
A variety of extraimmune system factors, including hormones, play a critical role in regulating immunity. Progesterone has been shown to affect immunity rodents and humans, mainly at concentrations commensurate with pregnancy. These effects are primarily mediated via the progesterone receptor (PR), which acts as transcription factor, although non-genomic PR activation have reported. In this study, we evaluated on rat dendritic cells (DCs) ranges encompassing physiologic pharmacologic...
GRP94 (gp96)-peptide complexes can be internalized by APCs and their associated peptides cross-presented to yield activation of CD8(+) T cells. Investigations into the identity (or identities) surface receptors have yielded conflicting results, particularly with respect CD91 (LRP1), which has been proposed essential for recognition uptake. To assess function in binding endocytosis, these parameters were examined mouse embryonic fibroblast (MEF) cell lines whose expression was either reduced...
The solution state coordination chemistry of Hg(ClO4)2 with tris[(2-(6-methylpyridyl))methyl]amine (TLA) was investigated in acetonitrile-d3 by proton NMR. Although Hg(II) is a d10 metal ion commonly associated notoriously rapid exchange between environments, as many six ligand environments were observed to be slow on the chemical shift time scale at select metal-to-ligand ratios. One these extensive heteronuclear coupling protons and 199Hg assigned complex [Hg(TLA)]2+. 5J(1H199Hg) = 8 Hz...
Abstract α-2M*-mediated antigen delivery leads to cross-presentation and improved cell-mediated immunity, suggesting that α-2M* may have applications for vaccines based on weakly immunogenic subunits. α2M* targets antigens APCs rapid internalization, processing, presentation. When used as an antigen-delivery vehicle, amplifies MHC class II presentation, demonstrated by increased antibody titers. Recent evidence, however, suggests encapsulation also enhance antigen-specific CTL immunity. In...
A correlation between expression of the glucose-regulated protein 78 kDa (GRP78) in malignant melanoma tumors and poor patient survival is well established. In this study, addition to demonstrating GRP78 tumor tissue, we investigated immune response against a group patients with different progression stages melanoma. Furthermore, analyzed glycosylation status immunoglobulin (Ig) G autoantibodies at these evaluated their capacities affect B-dependent kinase signaling pathway unfolded...
Aberrant fibroblast migration in response to fibrogenic peptides plays a significant role keloid pathogenesis. Angiotensin II (Ang II) is an octapeptide hormone recently implicated as mediator of organ fibrosis and cutaneous repair. Ang promotes cell but its phenotypic behavior has not been studied. We investigated signaling potential mechanism disease. Primary human fibroblasts were stimulated migrate the presence receptor 1 (AT1), 2 (AT2) or nonmuscle myosin (NMM antagonists. Keloid...
The coordination chemistry of Hg(II) with tris[(1-methylimidazol-2-yl)methyl]amine (TMIMA) was investigated. structures [Hg(TMIMA)2](ClO4)2 (1), [Hg(TMIMA)(NCCH3)](ClO4)2 (2) and [Hg(TMIMA)Cl]2(HgCl4) (3) were characterized by X-ray crystallography. Complex 1 has six strong Hg–Nimidazoyl bonds ranging from 2.257(5) to 2.631(6) Å. Ligand geometry suggests the Hg–N(NR3) distances 2.959(6) Å in reflects weak bonding interactions. This complex a 199Hg chemical shift −1496 ppm, significantly...
Tripodal N4 ligands tris[(1-methylimidazol-2-yl)methyl]amine (L1), bis[(1-methylimidazol-2-yl)methyl][(2-pyridyl)methyl]amine (L2) and [(1-methylimidazol-2-yl)methyl]-bis-[(2-pyridyl)methyl]amine (L3) were used to prepare five new [ML2](ClO4)2 (M = Cd(II), Hg(II)) complexes. All complexes had N8 metal coordination a trans-bicapped octahedral structure as determined by X-ray crystallography. Metal–nitrogen bond distances generally decreased in the order M–Namine > M–Npyridyl M–Nimidazoyl,...
Administered in vivo, covalent receptor-recognized α2-macroglobulin (α2M*)-antigen complexes enhance humoral and cell-mediated immunity. We hypothesized that vivo α2M*-encapsulation could be promoted the setting of vaccines co-deliver α2M* with unbound antigen, thereby eliminating need to prepare vitro. Mice immunized intradermally co-delivered OVA demonstrated antigen-specific immune responses, including anti-tumor similar those elicited by conjugated α2M*-OVA complexes. Enhanced immunity...
Oral and laryngeal cutaneous T-cell lymphoma (CTCL) is rare usually associated with poor prognosis. Here, we discuss 2 cases of oral CTCL that developed in heavily pretreated patients provide a review the literature. The first case 46-year-old African American male rapidly progressive disease, presenting lesion on his hard palate 6 months after being diagnosed CD4+CD8+ CTCL. His disease was widespread tumors >80% body surface area. Unfortunately, patient died ½ years diagnosis 7...
This Resource Letter is a checklist of popular books about physics and some its allied sciences, grouped by subject genre. Its principal purpose to help teachers provide advice guidance their students the lay public.