A5071504959- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Histiocytic Disorders and Treatments
- Animal Genetics and Reproduction
- Virus-based gene therapy research
- Cytomegalovirus and herpesvirus research
- CRISPR and Genetic Engineering
- Parvovirus B19 Infection Studies
- IL-33, ST2, and ILC Pathways
- T-cell and Retrovirus Studies
- Immunodeficiency and Autoimmune Disorders
- Inflammatory Bowel Disease
- Cellular Mechanics and Interactions
- HIV Research and Treatment
- Eosinophilic Disorders and Syndromes
- Ubiquitin and proteasome pathways
- Wind and Air Flow Studies
- Cleft Lip and Palate Research
- Cancer-related molecular mechanisms research
- Invertebrate Immune Response Mechanisms
- Hippo pathway signaling and YAP/TAZ
- Air Quality and Health Impacts
- Studies on Chitinases and Chitosanases
- Polyomavirus and related diseases
University of Glasgow
2010-2020
University of Bristol
2012
Versus Arthritis
2012
University of Manchester
2012
University of Oxford
2012
University Hospital Llandough
2012
University of Nottingham
2012
University of Alberta
1989-2005
Erasmus MC
2005
Princeton University
1989-1990
The Epstein-Barr virus (EBV) is one of the predominant tumor viruses in humans, but so far no therapeutic or prophylactic vaccination against this transforming pathogen available. We demonstrated that heterologous prime-boost with nuclear antigen 1 EBV (EBNA1), either targeted to DEC205 receptor on DCs expressed from a recombinant modified vaccinia Ankara (MVA) vector, improved priming antigen-specific CD4+ T cell help. This help supported expansion and maintenance EBNA1-specific CD8+ cells...
The development of high-grade, malignant B-cell lymphoma is a well-recognized complication human immunodeficiency virus (HIV) infection. Plasma cell neoplasms, however, have been rarely encountered in HIV-infected people. This study presents the morphologic and immunologic features an unusual plasma tumor occurring 31-year-old HIV-antibody–positive male. malignancy was characterized by widespread dissemination hypercalcemia at presentation clinically aggressive course. Immunoperoxidase...
Abstract EBV latent membrane protein 1 (LMP1) is an oncoprotein frequently expressed in nasopharyngeal carcinoma. We have generated transgenic mice expressing the carcinoma–derived CAO strain of LMP1 and B95-8 strain, using viral ED-L2 promoter for epithelial expression. LMP1CAO LMP1B95-8 induce transforming growth factor α expression epidermal hyperplasia. However, levels total receptor (EGFR) decline with appearance phosphorylated EGFR products, suggesting that negative feedback loop upon...
Abstract Background The importance of the malignant cell environment to its growth and survival is becoming increasingly apparent, with dynamic cross talk between neoplastic cell, leukocyte infiltrate stroma. Most cancers are accompanied by infiltration which, contrary an anticipated immuno-protective role, could be contributing tumour development cancer progression. Epstein-Barr virus (EBV) associated cancers, including nasopharyngeal carcinoma Hodgkin's Disease, show a considerable which...
An important role for B cells and immunoglobulin deposition in the inflammatory tumor cell environment has been recognized several cancers, this is recapitulated our murine model of inflammation-associated carcinogenesis: transgenic mice expressing Epstein-Barr virus oncogene LMP1 epithelia. Similarly autoimmune disorders, represents a key underlying event disease process. However, autoantigens most cases are not known. In other studies, overexpression enzymatically inactive mammalian...
The c-myc oncogene stimulates ribosomal biogenesis and protein synthesis to promote cellular growth. However, the pathway by which cells sense restore dysfunctional mRNA translation how this is linked cell proliferation growth not known. We here show that stress in cis triggered gly-ala repeat sequence of Epstein-Barr virus (EBV)-encoded EBNA1, results PI3Kδ-dependent induction E2F1 with consequent activation c-Myc proliferation. Treatment a specific PI3Kδ inhibitor Idelalisib (CAL-101)...
Abstract IκB kinase 2 (IKK2) is well known for its pivotal role as a mediator of the canonical NF-κB pathway, which has important functions in inflammation and immunity, but also cancer. Here we identify novel critical function IKK2 co-factor NEMO activation oncogenic c-Jun N-terminal (JNK) signaling, induced by latent membrane protein 1 (LMP1) Epstein-Barr virus (EBV). Independent activity, TGFβ-activated (TAK1) mediates LMP1 signaling complex formation, ubiquitination subsequent...
Background Non-coding RNAs have critical functions in diverse biological processes, particularly gene regulation. Viruses, like their host cells, employ such functional and the human cancer associated Epstein-Barr virus (EBV) is no exception. Nearly all EBV tumours express small, non-coding (EBERs) 1 2, however role viral pathogenesis remains largely obscure. Methodology/Principal Findings To investigate action of EBER1 vivo, we produced ten transgenic mouse lines expressing lymphoid...
The latent membrane protein-1 (LMP1) encoded by Epstein-Barr virus (EBV) is an oncoprotein which acts constitutive activation of various signalling pathways, including NF-kappaB. In so doing it leads to deregulated cell growth intrinsic the cancer as well having extrinsic affects upon tumour microenvironment. These properties and that a foreign antigen, lead proposition LMP1 may be good therapeutic target in treatment EBV associated disease. expressed several EBV-associated malignancies,...
Abstract The lymphomagenic action of myc genes in conjunction with Epstein‐Barr virus nuclear antigen‐1 (EBNA‐1) have been examined using transgenic mice several separate tests. Synergy between Myc and EBNA‐1 lymphomagenesis was revealed a cross breed study where co‐expression led to tumor latency period reduced significantly some crosses. In the resulting bitransgenic tumors, expression Eμ‐ not affected by expression. MoMLV utilized as transposon tag activate cellular oncogenes infection...
The Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is a sequence-specific DNA-binding protein that plays an essential role in viral episome replication and segregation, by recruiting the cellular complex of DNA onto origin (oriP) tethering mitotic chromosomes. Whereas mechanisms are well documented, those involved EBNA1 to chromatin far from being understood. Here, we have identified regulator chromosome condensation (RCC1) as novel partner for EBNA1. RCC1 major guanine nucleotide...