Mieczysław Gorzelak

ORCID: 0000-0003-4716-8575
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Research Areas
  • Bone health and osteoporosis research
  • Bone Metabolism and Diseases
  • Bone Tissue Engineering Materials
  • Chemical Synthesis and Characterization
  • Dental materials and restorations
  • Radioactive element chemistry and processing
  • Adrenal Hormones and Disorders
  • Psoriasis: Treatment and Pathogenesis
  • Cancer, Stress, Anesthesia, and Immune Response
  • Orthodontics and Dentofacial Orthopedics
  • Insect Pheromone Research and Control
  • Growth Hormone and Insulin-like Growth Factors
  • Dental Erosion and Treatment
  • Coral and Marine Ecosystems Studies
  • Stress Responses and Cortisol
  • Anesthesia and Neurotoxicity Research
  • Allergic Rhinitis and Sensitization
  • Bone and Dental Protein Studies
  • Hormonal Regulation and Hypertension
  • Bone fractures and treatments
  • Crystallization and Solubility Studies
  • Spondyloarthritis Studies and Treatments
  • Bone health and treatments
  • Cephalopods and Marine Biology
  • Muscle metabolism and nutrition

Medical University of Lublin
1996-2024

Psoriatic arthritis (PsA) is a seronegative arthropathy with many clinical manifestations, and it may affect nearly half of patients psoriasis. PsA should be diagnosed as early possible to slow down joint damage progression disability. To improve the diagnosis PsA, physicians look for peripheral inflammatory pain, axial dactylitis, buttock sciatic pain. In most pharmacologic treatment non-steroidal anti-inflammatory drugs, disease-modifying anti-rheumatic biologic agents effective. However,...

10.5114/aoms.2018.77725 article EN cc-by-nc-sa Archives of Medical Science 2018-10-26

Apatites are one of the most intensively studied materials for possible biomedical applications. New perspectives application apatites correspond with development nanomaterials and nanocompounds. Here, an effort to systematize different kinds human bioapatites forming bones, dentin, enamel was undertaken. The precursors hydroxyapatite were also considered. rigorous consideration compositions stoichiometry allowed us establish order in their mutual sequence. chemical reactions describing...

10.3390/ijms23179537 article EN International Journal of Molecular Sciences 2022-08-23

Background. The purpose of our study was to investigate the concentrations markers bone turnover in normal pregnancy and preeclampsia. Material Methods. Forty-five pregnant patients with preeclampsia, 78 healthy women (26 first, 26 second, third trimester pregnancy), 20 nonpregnant were included study. Serum osteoprotegrin (OPG), receptor activator nuclear factor kappa B ligand (sRANKL), turnover, osteocalcin CrossLaps—degradation products type I collagen, determined using ELISA method....

10.3109/10641955.2010.484084 article EN Hypertension in Pregnancy 2010-09-07

Developments in the field of nanostructures open new ways for designing and manufacturing innovative materials. Here, we focused on original calculating energy changes during substitution foreign ions into structure apatites bioapatites. Using these tools, energetic costs ion exchanges were calculated exemplary cases known from literature. It was established that most costly some cations inside anions, least tetrad channel positions. Real expenses bioapatites are much smaller comparison to...

10.3390/molecules27248913 article EN cc-by Molecules 2022-12-15

The introduction of the notion energy change resulting from ion exchange in apatites leads to question: how can some simple isomorphic series be described using mentioned idea? We concentrated on compounds: apatite, bioapatite, calcite, aragonite, celestine, K-, Zn- and Cu-Tutton's salts. It was demonstrated all series, except Tutton's salts, that crystal cell volume are, a way, dependent ionic radii introduced ions. linear relationships between variations universal crystallographic...

10.3390/ijms241411324 article EN International Journal of Molecular Sciences 2023-07-11

The matter constituting the enamels of four types organisms was studied. variability ions presented in molar units. It proven that changes water contents enamel are significantly positively related to Mg; inversely, there is also a strong connection with Ca and P, main components bioapatite. organic has same positive characteristics coupled Mg contents. Amelogenins matter, which synthesize rods, likely have role adjusting amount Mg, thus establishing whole enamel; this adjustment occurs...

10.3390/ijms242115974 article EN International Journal of Molecular Sciences 2023-11-04

This study primarily focused on the acid erosion of enamel and dentin. A detailed examination X-ray diffraction data proves that products acid-caused decay belong to family isomorphic bioapatites, especially calcium-deficient hydroxyapatites. They are a trajectory towards less crystallized substances. The increase in Bragg’s parameter d decrease energy necessary for changes were coupled with variability pH. was valid corrosive action solutions pH greater than 3.5. When processes natural...

10.3390/ijms252011297 article EN International Journal of Molecular Sciences 2024-10-21

The chemical composition and structure of bamboo octocoral Keratoisis spp. skeletons were investigated by using: Scanning Electron Microscopy SEM, Raman Microscopy, X-ray Diffraction XRD, Laser Ablation-Inductively Coupled Plasma LA-ICP, amino acid analyzers. Elements discovered in the nodes (mainly organic parts skeleton) corals showed a very interesting arrangement growth ring areas, most probably enabling application as palaeochronometers palaeothermometers. LA-ICP results that these...

10.3390/ijms24098355 article EN International Journal of Molecular Sciences 2023-05-06

Nowadays, due to a higher resistance drugs, antibiotics, and antiviral medicaments, new ways of fighting pathogens are intensively studied. The alternatives for synthesized compositions natural products, most which have been known in medicine long time. One the best-known investigated groups essential oils (EOs) their compositions. However, it is worth noting that method application can play second crucial part effectiveness antimicrobial activity. EOs possess various compounds exhibit based...

10.3390/molecules28114368 article EN cc-by Molecules 2023-05-26
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