A5044392404- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- Cancer-related cognitive impairment studies
- Celiac Disease Research and Management
- Epilepsy research and treatment
- Brain Tumor Detection and Classification
- Microscopic Colitis
- Glaucoma and retinal disorders
- Memory and Neural Mechanisms
- Dialysis and Renal Disease Management
- Viral gastroenteritis research and epidemiology
- Eosinophilic Esophagitis
- Diversity and Career in Medicine
- Identity, Memory, and Therapy
- Cancer survivorship and care
- Alkaline Phosphatase Research Studies
- Memory Processes and Influences
- Academic Writing and Publishing
- Family Caregiving in Mental Illness
- scientometrics and bibliometrics research
- Helicobacter pylori-related gastroenterology studies
- Acute Ischemic Stroke Management
- Advanced Neuroimaging Techniques and Applications
Imperial College London
2020-2024
Sapienza University of Rome
2020
Abstract INTRODUCTION Overlooking the heterogeneity in Alzheimer's disease (AD) may lead to diagnostic delays and failures. Neuroanatomical normative modeling captures individual brain variation inform our understanding of differences AD‐related atrophy. METHODS We applied neuroanatomical magnetic resonance imaging from a real‐world clinical cohort with confirmed AD ( n = 86). Regional cortical thickness was compared healthy reference 33,072) number outlying regions summed (total outlier...
Alzheimer's disease, the most common cause of dementia, causes a progressive and irreversible deterioration cognition that can sometimes be difficult to diagnose, leading suboptimal patient care.
Abstract The persistent underrepresentation of women in Science, Technology, Engineering, Mathematics and Medicine (STEMM) points to the need continue promoting awareness understanding this phenomenon. Being one main outputs scientific work, academic publications provide opportunity quantify gender gap science as well identify possible sources bias areas improvement. Brain Communications is a ‘young’ journal founded 2019, committed transparent publication rigorous work neuroscience,...
Episodic memory enables us to form a bank of autobiographical memories across our lifespan. The relationship between and laboratory-measures episodic is complicated these processes might be differentially affected by ageing (e.g. Diamond et al., [2020]. Different patterns recollection for matched real-world laboratory-based episodes in younger older adults. Cognition, 202, 104309.). Here, we examine whether the ability recall one's own visual perspective relates richness recall, how this...
Episodic memory impairment and brain amyloid-beta are two of the main hallmarks Alzheimer's Disease. In clinical setting, these often evaluated through neuropsychological testing amyloid PET imaging, respectively. The use in practice is only indicated patients with substantial diagnostic uncertainty due to atypical presentation, multiple comorbidities and/or early age onset. relationship between cognition has been previously investigated, but no study examined how features relate presence...
Depression has been suggested to be a cause of reversible cognitive impairment but also risk factor for neurodegenerative disease. Studies suggest that depression prevalence may high in early onset dementia, particularly Alzheimer's disease, this not systematically assessed biomarker-validated clinical dementia cohort date.To examine the prevalence, features, and association with amyloid pathology lifetime depressive symptoms memory clinic meeting appropriate use criteria PET imaging.We...
Abstract Alzheimer’s disease (AD) has been traditionally associated with episodic memory impairment and medial temporal lobe atrophy. However, recent literature highlighted the existence of atypical forms AD, presenting different cognitive radiological profiles. Failure to appreciate heterogeneity AD in past led misdiagnoses, diagnostic delays, clinical trial failures risks limiting our understanding disease. research requires incorporation new analytic methods that are as free possible from...
Abstract Background The link between late‐life depression and Alzheimer’s disease (AD) has long been investigated, however it is still unclear whether acts as a risk factor, prodromal feature or comorbid condition in AD. Clarifying the nature of this important implications early intervention diagnosis relatively recent introduction in‐vivo brain biomarkers for AD pathology offers chance to explore relationship pathologically‐confirmed neurodegeneration. Here, we examined association among...
Abstract Background The early cognitive profile of Alzheimer’s Disease (AD) is typically characterised by predominant impairment in episodic memory, reflecting medial temporal lobe dysfunction. However, little known about the associated with AD pathology those patients who meet Appropriate Use Criteria (AUC, Johnson et al., 2013) for Amyloid PET Imaging (API). In this group, frequently an atypical clinical course or presentation. Here, we systematically evaluate profiles AUC‐meeting a...
Objectives We recently found that approximately 50% patients referred for clinical amyloid PET imaging (API) have a history of depressive symptoms (Loreto et al. AAIC2021). Recent studies in selected research cohorts reported negative associations between left thalamic volume and both disease severity neuropsychiatric Alzheimer’s (AD) (Low 2019). Here, we performed whole-brain analysis patient cohort with confirmed AD examined the 8 pre-specified regions (Karavasilis 2017), depression...
Abstract Background Patterns of atrophy in the brain highly differ between individual Alzheimer’s Disease (AD) patients, however, most clinical research focuses on group‐level differences (Verdi et al., 2021). Here we used a novel technique, neuroanatomical normative modelling, to reveal patterns cortical thickness by quantifying deviations from range. We applied hierarchical Bayesian regression (HBR) model (Kia 2021), amyloid‐positive AD patients who had amyloid PET imaging at Imperial...
Objectives The typical onset of Alzheimers Disease (AD) is characterised by episodic memory impairment. However, AD pathology can present with atypical clinical features and/or mixed aetiologies, which often lead to diagnostic uncertainty. Biomarker evaluation using amyloid PET imaging (API) in this group guided published appropriate use criteria (Johnson et al., 2013). A large proportion these patients also referred for neuropsychological assessment. Here, we investigate the cognitive...
Objectives/Aims Depression has been reported as a possible risk factor for Alzheimer’s Disease, but also one of the clinical features well other dementias. Further, depression long associated with cognitive impairment in absence neurodegeneration (Connors et al . 2018). Here we sought to ascertain prevalence patients meeting widely accepted Appropriate Use Criteria Amyloid PET Imaging (API). We examined lifetime undergoing API real-world setting and compared our findings population data from...
Abstract Background The clinical use of amyloid‐PET imaging (API) is guided by a set published appropriate criteria (Johnson et al., 2013). Patients meeting these have suspected Alzheimer’s Disease (AD) accompanied an atypical presentation leading to substantial diagnostic uncertainty. Previous large‐cohort studies investigated this population from standpoint, looking at the impact using elucidate aetiology impairment. However, data concerning their phenotypes lacking. In study, we...