A5056517843- Osteoarthritis Treatment and Mechanisms
- Shoulder Injury and Treatment
- Cytokine Signaling Pathways and Interactions
- Shoulder and Clavicle Injuries
- Orthopedic Surgery and Rehabilitation
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Hip disorders and treatments
- Immune Response and Inflammation
- Lower Extremity Biomechanics and Pathologies
- Total Knee Arthroplasty Outcomes
- Asthma and respiratory diseases
- Bone fractures and treatments
- Foot and Ankle Surgery
- Nerve Injury and Rehabilitation
- Musculoskeletal Disorders and Rehabilitation
- Children's Physical and Motor Development
- Veterinary Equine Medical Research
- Sports injuries and prevention
- Infectious Diseases and Tuberculosis
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Diabetic Foot Ulcer Assessment and Management
- Rheumatoid Arthritis Research and Therapies
University of Rijeka
2010-2024
University Hospital Centre Zagreb
2017-2024
Klinika za psihijatriju Vrapče
2019-2023
University of Oslo
2012-2019
Klinička bolnica "Sveti Duh"
2017
University Clinical Hospital Mostar
2017
University of Mostar
2017
Abstract Among the predisposing factors to osteoarthritis (OA), a frequent destructive joint disease, is complex genetic heritage including interleukin‐1 family members like IL1β (IL1B) and IL1 receptor antagonist (IL1RN) genes. The aim of this study was investigate allelic genotypic frequencies IL1B gene single nucleotide polymorphism (SNP) at −511(G>A) variable number tandem repeat (VNTR) in IL1RN Croatian Caucasian population hip OA (HOA) cases healthy controls. A total 259 HOA...
Primary osteoarthritis (OA) is the most common type of a joint disease. It has polygenic risk inheritance pattern and affects older people. The etiology this disease not fully understood. aim study was to investigate associations between polymorphisms in pro-inflammatory interleukin-17 (IL17A IL17F) anti-inflammatory Toll-like Receptor 10 (TLR10) genes with for development advanced stage hip knee primary OA Croatian population. A total 500 patients 597 controls were genotyped IL17A SNP...
Current modalities for osteoarthritis (OA) treatment are partially safe and effective, only alleviate the disease symptomatology, but do not modify progression structural changes of disease. At present, there is no approved effective disease-modifying OA drug (DMOAD) clinical application. Therefore, an urgent need discovery DMOAD in order to treat OA. Hopefully, new DMOADs would also pave way better understanding pathophysiology. Given fact that still adequate remedy will course OA, a number...
Genetic predisposition to the complex hereditary disease like osteoarthritis (OA) of large joints (hip and knee) includes interleukin-1 gene (IL-1) cluster on chromosome 2. Using a case-control study with 500 OA patients (240 knee 260 hip patients, all joint replacement), we analysed frequencies IL-1 polymorphisms in Croatian Caucasian population. The control samples came from 531 healthy individuals including blood donors. We genotyped two single nucleotide locus at IL-1A (-889, C>T,...
ABSTRACT Family with sequence similarity 46, member A (FAM46A) gene VNTR and BCL2‐Associated Athanogene 6 (BAG6) rs3117582 polymorphisms were genotyped in a case–control study 474 large‐joint (hip knee) osteoarthritis (OA) patients 568 controls Croatian population by candidate‐gene approach for association OA. We found that BAG6 SNP genotypes associated protection (major allele homozygote) susceptibility (major–minor heterozygote) to major (A) was reduced risk OA while the minor (C)...
Purpose: The purpose of the study was to determine whether lateral soft-tissue release (LSTR) has a beneficial or detrimental effect on outcome distal Chevron first metatarsal osteotomy (DCMO) in treatment moderate hallux valgus (HV). Methods: We compared different surgical treatments 2 groups patients: group I (23 patients, 25 feet, average age 55 [from 43 77] years) subjected DCMO only, whereas II (18 23 59 52 70] years]) with LSTR. American Orthopaedic Foot and Ankle Society’s Hallux...
Abstract Primary osteoarthritis (POA) is a complex hereditary disease that involves the interplay between genetics and epigenetics. MicroRNA molecules play important roles in epigenetic mechanisms. MicroRNA‐146a (miR‐146a) negative regulator of immune response (OA). So, variations miR‐146a gene could affect OA risk. The aim this study was to investigate relationships single nucleotide polymorphisms (SNPs) miR‐146a, interleukin‐6 (IL‐6), Toll‐like receptor 10 (TLR10), tumor necrosis...
We studied the genetic epidemiology of primary large-joint (hip and knee) osteoarthritis (OA), in order to find disease risk factors by a candidate-gene approach. used case-control study Croatian Caucasian population. genotyped 500 OA patients (260 hip, 240 knee; both with total joint replacements) 597 healthy individuals for single-nucleotide polymorphisms (SNPs) interleukin 17A (IL17A) (rs2275913) IL17F (rs763780 rs1889570) genes. On basis our population allelic genotypic frequencies...
The aim of this study was to investigate differences in functional recovery eight years after total hip arthroplasty patients who underwent joint surgery using two different approaches: the classic lateral approach and anterolateral minimally invasive surgical approach.
Sažetak.Sindrom karpalnog tunela (SKT) dobro je poznata, najčešće dijagnosticirana kompresivna neuropatija i čini 90 % svih te prisutna u 3,8 opće populacije.Uzrokovana oštećenjem nervus medianus (NM) području tunela, ograničenog karpalnim kostima transverzalnim ligamentom.SKT se klasificira idiopatski sekundarni.Patogeneza SKT-a kompleksna uključuje kompresiju trakciju NM-a a još uvijek nije potpunosti razjašnjena.U dijagnostici su uporabi brojni klinički testovi, elektromioneurografija...
The modern indications for Chiari pelvic osteotomy (CPO) have narrowed and the number of such operations performed has diminished markedly. So far published long-term experience with CPO indicate fact that in selected patients satisfactory functional results can be achieved. aim this study was to investigate parameters which influence survival its conversion into total hip arthroplasty (THA).This is a single-centre retrospective case-series study. In period from 1976 2012, it included 172...
The European Wrist Arthroscopy Society (EWAS) organizes a Tour (WAT) twice year in order that participants can attend numerous wrist arthroscopies directly the operating theater “compagnonnage” way. WAT was held France, and it included three cities eight surgeons five hospitals during days.