A5043262845- Heavy Metal Exposure and Toxicity
- Venomous Animal Envenomation and Studies
- Animal Nutrition and Physiology
- Diet and metabolism studies
- Pomegranate: compositions and health benefits
- Synthesis of Indole Derivatives
- Cellular transport and secretion
- Phytochemicals and Medicinal Plants
- Synthesis and biological activity
- Coccidia and coccidiosis research
- Medicinal Plants and Neuroprotection
- Parasite Biology and Host Interactions
- Curcumin's Biomedical Applications
- Chemotherapy-induced organ toxicity mitigation
- Immunotoxicology and immune responses
- Helminth infection and control
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Cannabis and Cannabinoid Research
- Pesticide Exposure and Toxicity
- Effects of Environmental Stressors on Livestock
- Botanical Research and Chemistry
- Animal Behavior and Welfare Studies
- Rabies epidemiology and control
- Pharmacological Effects of Medicinal Plants
Charles Darwin University
2024-2025
The University of Queensland
2019-2025
University of Jos
2019-2024
Park Centre for Mental Health
2023-2024
Ahmadu Bello University
2018-2021
Abstract The phospholipid and free fatty acid (FFA) composition of neuronal membranes plays a crucial role in learning memory, but the mechanisms through which activity affects brain’s lipid landscape remain largely unexplored. levels saturated FFAs, particularly myristic (C14:0), strongly increase during stimulation memory acquisition, suggesting involvement phospholipase A1 (PLA1) synaptic plasticity. Here, we show that genetic ablation PLA1 isoform DDHD2 mice dramatically reduces FFA...
Recent years have reported a rise in the occurrence of gastric ulceration especially among young children and adults. This study investigated mechanism by which two types Saudi honey: Alnahal Aljawal honey (Wadi) or Bin Ghaithan (Talh) exerted their antiulcer potential indomethacin-induced ulceration. Four cohorts rats were used: Group 1; Healthy controls, 2; Ulcerative animals, 3; + Wadi treatment, 4; Talh treatment. We profiled levels different indicators oxidative stress including...
Engaging in research during medical training is crucial for fostering critical thinking, enhancing clinical skills, and deepening understanding of science. Despite its importance, the shortage physician-scientists lingers with many trainees junior doctors encountering challenges navigating process. Drawing on current literature, this article provides a comprehensive roadmap, categorising 12 actionable strategies into five themes, to help overcome common obstacles optimise their experience....
This study investigated the effects of kaempferol and zinc gluconate on neurobehavioural oxidative stress changes in Wistar rats exposed to noise. Thirty (30) were randomly divided into five groups: Groups I II administered with deionized water (DW); Group III, (K); IV, (Zn); V, + gluconate. II, V subjected noise (N) induced by exposing 100 dB (4 h/day) for 15 days, from day 33 48 after starting drug treatments. Neuromuscular coordination, motor strength, sensorimotor reflex, learning...
Many researchers worldwide have focused on the health impact of coronavirus disease 2019 (COVID-19) pandemic without paying much emphasis to environmental impacts associated with pandemic. Evidence suggests that prior there was an alarming increase in pollution due rising industrialization, particular urban areas. Following COVID-19 pandemic, satellite data over Asia and Europe showed a substantial decrease air pollution, nitrogen dioxide. However, industrial household wastes may pose...
Anxiety disorders constitute a spectrum of psychological conditions affecting millions individuals worldwide, imposing significant health burden. Historically, the development anxiolytic medications has been largely focused on neurotransmitter function and modulation. However, in recent years, neurolipids emerged as prime target for understanding psychiatric pathogenesis developing novel medications. Neurolipids influence various neural activities such neurotransmission cellular functioning,...
The veterinarian is daily faced with the challenge of diagnosing several disease conditions in different animals. Quantifying cortisol levels has been used evaluation anxiety and distress initiated by infectious non-infectious conditions, mismanagement, transportation, adverse environmental temperature surgical operations. hormone-cortisol implicated immunologic metabolic processes can thus serve as a marker to monitor animal welfare. Several factors affect specific test be carried out which...
Background: The World Health Organization included snakebite envenomation among Neglected Tropical Diseases in 2017. importance of natural products from plants is enormous, given that most prescribed drugs originate plants. Among this Mucuna pruriens and Mimosa pudica, with many registered patents asserting their health benefits. Objective: This study investigated the vitro neutralizing effects seed pudica root extracts on venoms Naja nigricollis Bitis arietans. Methods: In mice, LD50...
Radiofrequency-electromagnetic radiation (RF-EMR) exposure during gestational and neonatal development may interact with the foetus neonate considered hypersensitive to RF-EMR, consequently resulting in developmental defects associated neuropsychological neurobehavioral disorders, including learning memory impairment. This study assessed potential of Myrtenal (Myrt) improve deficits C57BL/6 mice exposed RF-EMR development.Thirty-five male were randomly allocated into 5 cohorts, each...
The occurrence of chronic neurodegenerative disorders is on the rise, but with no effective treatment due to paucity information pathological mechanism underlying these disorders. Thus, this study investigated role oral administration myrtenal in mitigating memory deficits and neuro-biochemical alterations streptozotocin-demented mice model. Mice (n = 35) were randomly allocated into five cohorts consisting 7 each; Group I: Control received vehicle alone; II: streptozotocin; III:...
Objective: To investigate the antioxidant efficacy of oral orientin on 900 MHz radiofrequency-electromagnetic radiation-induced oxidative stress in mice.Methods: The mice were randomly allotted into 5 groups consisting 7 each. deionised water and radiofrequency electromagnetic radiations (RF-EMR) administered with while was to RF-EMR + low dose group (10 mg/kg), high (20 mg/kg) mg/kg). All except exposed radiation for 28 consecutive days (1 h/day). Learning memory assessed via step-down...
Background: Snakebite envenomation is a global priority ranked top among other neglected tropical diseases. There folkloric claim that Uvaria chamae beneficial for the management of snakebite and wounds in African ethnobotanical surveys. Besides, there are many registered patents asserting health benefits U. chamae. Objective: This study aimed to investigate chamae’s potentials identify candidates development tools treatment N. nigricollis envenomation. Methods: Freshly collected leaves were...
Cisplatin (CISP) is one of the most widely used anti-cancer chemotherapeutic agents with remarkable efficacy against various types cancers. However, it has been associated nephrotoxicity amongst other undesirable side effects. Pomegranate (PE) a potent antioxidant and anti-inflammatory agent effective cancer, superior benefit not being common toxicities related to use conventional agents. application PE limited by its reduced solubility decreased bioavailability. We investigated potential...
Commercial poultry farming is expanding every day and contributing to the provision of affordable high-quality protein. However, this sector confronted with many diseases which coccidiosis among most important. There are registered patents affirming health benefits Garcinia kola in poultry.Evaluation vitro anticoccidial activities extracts fractions against Eimeria tenella oocyst was carried out.Fresh seeds G. were collected, dried under shade at room temperature, pulverized using a mortar...
Abstract This study investigated the effects of pretreatment with antioxidants, kaempferol, and zinc gluconate on serum biochemical changes impairment in body weight gain following noise-exposure Wistar rats. Thirty-five animals were evenly grouped into five cohorts: Groups II, III, IV, V exposed to noise stress, induced by exposing rats 100 dB (4 hr/day) for 15 days, from days 33 48 after starting drug treatments. Treatment kaempferol and/or mitigated noise-induced deficits gain, levels...
Cisplatin (CISP) ranks among the most used chemo-therapeutic agents with exceptional efficacy against testicular cancer other diverse types of cancers. However, it has been associated nephrotoxicity side effects. Pomegranate (PE) is an effective anti-inflammatory and antioxidant compound, protecting several chemotherapy-linked toxicities. The use PE are limited due to its low bioavailability poor solubility. We investigated potential a novel nanoparticle (NP) encapsulating formulation...
Liver cancer (LC) ranks as the second most prevalent cause of cancer-related deaths. Herbaceous plants are valuable sources complementary, adjuvant, or alternative anti-tumor therapy they contain natural active ingredients with anti-cancer potential. Although clinical use 3, 3′-Diindolylmethane (DIM) has been established, its low chemical stability and bioavailability, limits therapeutic applications. Increasing effort undertaken to improve DIM's biological activity including...
It is well-established that specific herbal plants contain natural active ingredients have demonstrated anti-cancer potential. Therefore, they are considered highly beneficial as a potential adjuvant, alternative or complementary agent in therapy. However, the low chemical stability and limited bioavailability of 3, 3'-Diindolylmethane (DIM), plant-derived compound used clinical settings, limit its therapeutic applications. To overcome this challenge, researchers focused on developing...