A5089962472- Bacteriophages and microbial interactions
- RNA and protein synthesis mechanisms
- Bacterial Genetics and Biotechnology
- Cancer Research and Treatments
- Antibiotic Resistance in Bacteria
- Plant Virus Research Studies
- Adipose Tissue and Metabolism
- Vibrio bacteria research studies
- Mitochondrial Function and Pathology
- Antimicrobial Peptides and Activities
- ATP Synthase and ATPases Research
- Genomics and Phylogenetic Studies
Massachusetts Institute of Technology
2021-2024
Whitehead Institute for Biomedical Research
2021
Howard Hughes Medical Institute
2021
For electrons to continuously enter and flow through the mitochondrial electron transport chain (ETC), they must ultimately land on a terminal acceptor (TEA), which is known be oxygen in mammals. Paradoxically, we find that complex I dihydroorotate dehydrogenase (DHODH) can still deposit into ETC when reduction impeded. Cells lacking accumulate ubiquinol, driving succinate (SDH) reverse enable deposition onto fumarate. Upon inhibition of reduction, fumarate sustains DHODH activities. Mouse...
Abstract Bacteria have evolved diverse immunity mechanisms to protect themselves against the constant onslaught of bacteriophages 1–3 . Similar how eukaryotic innate immune systems sense foreign invaders through pathogen-associated molecular patterns 4 (PAMPs), many bacterial that respond bacteriophage infection require phage-specific triggers be activated. However, identities such and sensing remain largely unknown. Here we identify investigate anti-phage function CapRel SJ46 , a fused...
Eukaryotic innate immune systems use pattern recognition receptors to sense infection by detecting pathogen-associated molecular patterns, which then triggers an response. Bacteria have similarly evolved immunity proteins that certain components of their viral predators, known as bacteriophages
Type I toxin-antitoxin (TA) systems typically consist of a protein toxin that imbeds in the inner membrane where it can oligomerize and form pores change permeability, an RNA antitoxin interacts directly with mRNA to inhibit its translation. In Escherichia coli, symE/symR is annotated as type TA system non-canonical toxin. SymE was initially suggested be endoribonuclease, but has predicted structural similarity DNA binding proteins. To better understand function, we used RNA-seq examine...
Eukaryotic innate immune systems use pattern recognition receptors (PRRs) to sense infection by detecting pathogen-associated molecular patterns, which then triggers an response. Bacteria have similarly evolved immunity proteins that certain components of their viral predators known as bacteriophages. Although different can recognize phage-encoded triggers, individual bacterial only been found a single trigger during infection, suggesting one-to-one relationship between PRRs and ligands....