Recently, the applications of deep eutectic solvents (DESs) as green and sustainable for solubilization functional foods phytophenols have dramatically risen concerning global issues on utilization organic solvents. Nevertheless, developing a suitable DES system phytocomponents to enhance its solubility bioavailability is complex requires sound experimental setup. Herein, we attempted develop encompassing choline chloride (ChCl) along with oxalic acid (OA), l-glutamine (l-Glu), urea (U),...

The present study aimed to develop enteric-coated mucoadhesive pellets of Tofacitinib citrate (TOF) for site-specific delivery in the treatment ulcerative colitis (UC). formulation (B2) was selected based on uniform particle size distribution, flow properties, and drug content. Further, it showed robust mechanical characteristics minimized friability. FTIR studies revealed purity TOF good compatibility with excipients. Meanwhile, DSC XRD demonstrated successful confinement reduced...

Venlafaxine (VLF) is the most commonly used drug for treatment of depressive disorder. The oral bioavailability VLF low. Therefore, present study emphasized development niosomes formulation solubility and permeation improvement. niosome-VLF was formulated using a thin film hydration technique employing different molar ratios Span 40 cholesterol. optimization performed Box-Behnken screening model, which employs numerical optimization. optimized niosmoes-VLF showed Particle size: 264.2 ± 2.2...

In the present investigation, fabrication and statistical optimization of chitosan-alginate polyelectrolyte complex (PEC) beads were performed for controlled delivery Cilnidipine (CIL). PEC containing CIL prepared by ionic cross-linking with calcium chloride. A was employing a 32 full factorial design. Graphical using overlay plot provides optimum combination both factors desired ranges response. The formulation (CB-O) developed sodium alginate (2·2%w/v) chitosan (1·2% w/v). CB-O showed...

The present work endeavors fabrication of fast dissolving buccal film clonidine hydrochloride by employing quality design (QbD) based approach. total nine formulations were prepared according to formulation helped JMP software 13.2.1. patient oriented target product profiles earmarked and on that basis critical attributes identified. Preliminary screening studies along with initial risk assessment eased the selection film-forming polymer (HPMC E 15) plasticizer (PEG 400) as CMAs for films. A...

Abstract: Background: Eprosartan mesylate (EM) is a poorly aqueous soluble drug belonging to BCS-class II suffers from low bioavailability (13%). The present study involves an effort for improving dissolution and thus the of EM using solid dispersion approach. Methods: Solid (SD) was prepared by melting, solvent evaporation kneading method different ratios polymers (PEG-4000, Eudragit E-100, PVP K-30, Poloxamer-407, L-100). Phase solubility revealed highest in K-30 at 1:2 ratios. state...

Antibiotics and antiinflammatory agents are the primary main therapeutic categories in treatment of otitis media. One simpler feasible approaches minimizing problem repeated use subsequent resistance is development sustained release formulation. Therefore, present investigation aimed to develop a situ gel formulation containing combination broad spectrum antibiotic for management otits The prolonged achieved by phase transition Poloxamer 407 (in situ) from sol at physiological temperature...

The present study endeavours to develop a solid self-microemulsifying nutraceutical drug delivery system for hesperidin (HES) using quality by design (QbD) improve its biopharmaceutical attributes.A 32 full factorial was employed the influence of factors on selected responses. Risk assessment performed portraying Ishikawa fishbone diagram and failure mode effect analysis (FMEA). in vivo antidiabetic carried induced diabetic rats.The optimised liquid SMEDDS-HES (OF) formulation showed...

Background: Bosentan monohydrate (BM), a dual endothelin receptor antagonist, is indicated for the treatment of patients with pulmonary arterial hypertension (PAH). It poorly soluble in water, and having absolute bioavailability 50%. Objective: The aim present work to develop evaluate solid dispersions (SD) water drug bosentan (BM). Method: Solid (SDs) systems BM were prepared Hydroxy propyle β-cyclodextrin (HPβ-CD) Polyethylene glycol (PEG-4000) polymers using spray drying technique....

In presented work Alginate-Neusilin US2 micro-composite beads (MCBs) were formulated and optimized for oral delivery of cilnidipine (CIL). Optimized formulation CIL loaded MCB (BA-O) exhibits particle size (1.55 ± 0.05mm), entrapment efficiency (82.35 1.5%), drug release after 12h (69.27 2.2%). vitro indicates sustained behavior following anomalous diffusion mechanism. The desirability function helps in formulating a new with desired values response. Furthermore, multiple linear regression...

A selective and sensitive reverse phase high performance liquid chromatography (RP-HPLC) method was developed validated for the determination of Eprosartan mesylate in rat plasma. single step protein precipitation carried out with acetonitrile to deproteinized plasma sample. chromatographic separation achieved on a Phenomenox, Gemini C18 (250x4.6 mm, 5 μm) column using water (45:55) as mobile pH adjusted 3.4 orthophsophoric acid (85%) at flow rate 1 mL/min. The intensity peak monitored 235...