A5103240342- Streptococcal Infections and Treatments
- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Monoclonal and Polyclonal Antibodies Research
- Rheumatoid Arthritis Research and Therapies
- Protein Tyrosine Phosphatases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Genetics, Bioinformatics, and Biomedical Research
- Species Distribution and Climate Change
- Mast cells and histamine
- Respiratory viral infections research
- Protease and Inhibitor Mechanisms
- Systemic Lupus Erythematosus Research
- Advanced Biosensing Techniques and Applications
- Biochemical and Structural Characterization
- Inflammatory mediators and NSAID effects
- Antibiotic Use and Resistance
- 3D Printing in Biomedical Research
- Research on Leishmaniasis Studies
- Complement system in diseases
- Telemedicine and Telehealth Implementation
- Antimicrobial Resistance in Staphylococcus
- Antimicrobial Peptides and Activities
- Environmental Education and Sustainability
- Innovation and Socioeconomic Development
University of St Andrews
2023-2024
University of Strathclyde
2009-2023
University of Glasgow
2007-2011
University of Cambridge
2011
Pneumolysin is an important virulence factor of the human pathogen Streptococcus pneumoniae. Sequence analysis ply gene from 121 clinical isolates S. pneumoniae uncovered a number alleles. Twenty-two strains were chosen for further analysis, and 14 protein alleles discovered. Five these had been reported previously, remaining 9 novel. Cell lysates used to determine specific hemolytic activities pneumolysin proteins. Six showed no activity, 16 hemolytic, varying degrees. We report that...
Objective. In the present study we evaluated use of four commercially available fluorescent probes to monitor disease activity in murine CIA and its suppression during glucocorticoid therapy.
Periodontitis is a chronic inflammatory and bone-destructive disease. Development of periodontitis associated with dysbiosis the microbial community, which may be caused by periodontal bacteria, such as Porphyromonas gingivalis. Mast cells are sentinels at mucosal surfaces potent source mediators, including tumor necrosis factors (TNF), although their role in pathogenesis remains to elucidated. This study sought determine contribution mast local bone destruction following oral infection P....
The unique species specificity of the bacterial cytolysin intermedilysin is explained by its requirement for human complement regulator CD59 as primary receptor. Binding studies using individual domains mapped CD59-binding site to domain 4 and swap mutants between rabbit (non-intermedilysin-binding) implicated a short sequence (residues 42-59) in binding intermedilysin. We set out map more closely first looked regions homology terminal components that bind CD59, C8 C9. A nine amino acid...
‘Antibiotics under our feet’ is a Scottish citizen science project that aimed to raise capital in primary school learners and their teachers through measurement of microbial diversity urban soil samples the search for novel antimicrobial compounds. Resistance antibiotics rising, posing global threat human health. Furthermore, science, technology, engineering mathematics (STEM) skills are crisis, jeopardising capacity mobilise as society fight resistance (AMR). Originally conceived response...
“Antibiotics under our feet” is a Scottish citizen science project that aimed to raise capital in primary school learners and their teachers through measurement of microbial diversity urban soil samples the search for novel antimicrobial compounds. Resistance antibiotics rising, posing global threat human health. Furthermore, science, technology, engineering mathematics (STEM) skills are crisis, jeopardising capacity mobilise as society fight resistance (AMR). Originally conceived response...
Objectives We have previously shown mitogen-activated protein kinase phosphatase 2 (MKP-2) to be a key regulator of proinflammatory cytokines in macrophages. In the study presented here, we investigated role MKP-2 inflammatory arthritis with particular focus on neutrophils. Methods To achieve this, subjected deficient and wild type mice collagen antibody induced arthritis, an innate model determined disease pathology. further our investigation, depleted neutrophils prophylactic therapeutic...
“Antibiotics under our feet” is a Scottish citizen science project that aimed to raise capital in primary school learners and their teachers through measurement of microbial diversity urban soil samples the search for novel antimicrobial compounds. Resistance antibiotics rising, posing global threat human health. Furthermore, Science, Technology, Engineering Maths (STEM) skills are crisis, jeopardising capacity mobilise as society fight resistance (AMR). Originally conceived response AMR...