A5082820503- Advanced machining processes and optimization
- Advanced Measurement and Metrology Techniques
- Advanced Surface Polishing Techniques
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Iterative Learning Control Systems
- Manufacturing Process and Optimization
- Reproductive Biology and Fertility
- Studies on Chitinases and Chitosanases
- Sperm and Testicular Function
- Energy Efficiency and Management
- Metabolism, Diabetes, and Cancer
- Advanced Numerical Analysis Techniques
- Adhesion, Friction, and Surface Interactions
- Growth Hormone and Insulin-like Growth Factors
- Enzyme Structure and Function
- Cancer, Hypoxia, and Metabolism
- Optical measurement and interference techniques
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Advanced Machining and Optimization Techniques
- Odor and Emission Control Technologies
- Diabetes Management and Research
- Advanced Chemical Sensor Technologies
- Pancreatitis Pathology and Treatment
- Air Quality Monitoring and Forecasting
Kyoto University
2016-2025
Aoyama Gakuin University
2025
Kyoto Katsura Hospital
2016-2021
Japan Society for the Promotion of Science
2018-2019
Yokohama National University
2015-2018
Kumamoto University
1981-2006
Kobe University
1977-2003
Hyogo Medical University
1981
When cutting flexible metal workpieces, the mechanical characteristics of fixture play a crucial role in suppressing deformation and vibration. Previously, influence design elements on workpiece vibration has been studied with aim gaining fundamental understanding phenomenon. Meanwhile, there limited research contact area between workpiece, is need for further to understand phenomenon establish guidelines fixtures. In this paper, an experimental approach proposed characterize relationship...
The damping characteristics of machine tool support system has a great influence on the rocking vibration amplitude. In our previous study, for been proposed to increase without decreasing stiffness. this damper is applied various tools. Results indicate that effective machines larger than already applied. However, coefficient can be different between even with same contact area and preload. This suggests possible confounding factor should considered when determining coefficient.
Inflammatory response induces phenotypic modulation of fibroblasts into myofibroblasts. Although transforming growth factor-βs (TGF-βs) evoke such transition, the details mechanism are still unknown. Here, we report that a LIM domain protein, cysteine-and glycine-rich protein 2 (CSRP2 [CRP2]) plays vital role in functional expression profile myofibroblasts and cancer-associated (CAFs). Knock-down CRP2 severely inhibits smooth muscle cell (SMC) genes, motility, CAF-mediated collective...
The ecdysone receptor (EcR) possesses the remarkable capacity to adapt structurally different types of ligands. EcR binds ecdysteroids, including 20-hydroxyecdysone (20E), as well nonsteroidal synthetic agonists such insecticidal dibenzoylhydrazines (DBHs). Here, we report crystal structures ligand-binding domains Heliothis virescens EcR/USP bound DBH agonist BYI09181 and imidazole-type compound BYI08346. region delineated by helices H7 H10 opens up tightly fit a phenyl ring ligands an...
The acute in vitro effect of alloxan on glucagon and insulin secretion from the isolated perfused rat pancreas was examined. Alloxan alone produced transient secretion. Pretreatment with attenuated both stimulatory glucose inhibitory Exposure to varying doses either partially or completely inhibited induced by arginine presence absence glucose. On contrary, pretreatment complex effects arginine-induced In glucose, response infusion lower exposed than control experiment. however, an...
Compounds classified as benzoylphenylurea (BPU), such diflubenzuron (DFB), are used insecticides. Although BPU disrupts molting by inhibiting chitin biosynthesis and exhibits insecticidal activity, their exact mode of action remains unknown. Since epidermal cells proliferate morphologically change from squamous to columnar during the early stages insect molting, we speculate that a transition similar epithelium mesenchyme occurs may inhibit this transition. Here, addressed possibility. We...
The support stiffness model and the tuning technique are applied to a practical situation. is integrated with finite element analysis (FEA) simulate rocking vibration mode. of machining center prototype calculated based on model. used determine placement structures in simulation. into three dimensional as springs. Rocking modes obtained from simulations by using To compare results, simulation without conducted. An experiment also conducted same that Without model, difference between...
Effect of successful treatment on plasma glucagon response to arginine was studied in patients with diabetes mellitus, Cushing's syndrome and hypothyroidism. Exaggerated infusion diabetic subjects normalized those successfully treated sulfonylureas significantly improved insulin. Patients hypothyroidism also exhibited excessive responsiveness glucagon, which were completely following treatment. The results suggest that the metabolic derangement is a main etiologic factor inducing...
In order to elucidate the abnormality of pancreatic polypeptide (PP) secretion in diabetes mellitus, basal plasma PP levels and their response oral glucose loading were measured normal subjects diabetic patients. Fasting significantly elevated patients with mellitus. Oral administration 50 g elicited an exaggerated rise as compared subjects. This was partially but improved after treatment, augmented insulin. These results indicate existence abnormal mellitus which is probably caused by...
Plasma pancreatic polypeptide (PP), a newly recognized hormone, was studied in healthy subjects and patients with chronic pancreatitis. After an oral load of 50 g meat extract, the plasma concentration PP showed rapid fourfold rise at 20 min controls. In contrast, level rose only 1.8-fold This difference statistically significant (P less than 0.05). The increase rate during test each subject correlated significantly 0.01) total amylase output maximal measured by pancreozymin-secretin test....
In the precision machining process, ambient temperature is maintained to 20 °C minimize thermal deformations. Much energy consumed maintain temperature. The use of compensation systems can consumption room cooling systems. However, influence deformation induced by upon workpieces not clear. This paper investigates effect linear expansion coefficient difference between a machine tool and change. Machining experiments are conducted for steel aluminum workpieces. results agree with calculation.
It is necessary to increase the damping of a machine support structure (support damping) reduce residual vibrations caused by rocking vibration. The stiffness system stiffness) also an important parameter that needs be considered while designing tools, avoid low frequency vibrations. However, conventional passive damper supports decrease increasing damping. In our previous study, viscoelastic non-linear for shear vibrations, where vertical preload determines its coefficient, was developed...