Dental peri-implantitis is characterized by a multifactorial etiology. The role of metal elements as an etiological factor for still unclear. aim this study was to investigate the incidence in bone and mucosal tissues around dental Grade 4 CP titanium implants with signs human patients.In prospective pilot study, all patients were enrolled consecutively two centers. Bone soft tissue samples indication explantation analyzed different (Ca, P, Ti, Fe) means synchrotron radiation X-ray...

Abstract Aim To explore the M1/M2 status of macrophage polarization from healthy, gingivitis, and periodontitis patient samples. Materials methods Gingival biopsies were collected 42 individuals (14 18 periodontitis, 10 healthy samples) receiving periodontal therapy. Histomorphology analysis was performed with haematoxylin eosin staining. Immunofluorescence using a combination CD68 (macrophages), iNOS (M1), CD206 (M2) in order to acquire changes at single‐cell resolution. Macrophages...

While the number of coronavirus cases from 2019 continues to grow, hospitals are reporting shortages personal protective equipment (PPE) for frontline healthcare workers. Furthermore, PPE eyes and mouth, such as face shields, allow additional protection when working with aerosols. 3-D printing enables easy rapid production lightweight plastic frameworks based on open-source data. The practicality clinical suitability four shields printed using a fused deposition modeling printer were...

Micro-organisms are important triggers of peri-implant inflammation and analysing their diversity is necessary for peri-implantitis treatment. This study aimed to analyse compare the microbiota associated with individuals peri-implantitis, as well clinically healthy implant sites.Subgingival biofilm samples were taken from 10 at least 1 implant. DNA was extracted bacterial 16S rRNA genes amplified using universal primers. After cloning PCR-products, inserts positive clones digested...

Long-term data concerning the impact of missing keratinized mucosa (KM) on periimplant tissue health are rare. The importance KM for implant success remains unclear.Two hundred eleven patients with 967 dental implants were analyzed up to 15 years after placement. Implants divided into two groups: no (NKM) and KM. Evaluated parameters plaque index (mAPI), bleeding (mSBI), probing (BOP), depth (PD), width KM, radiographic vertical bone level.mAPI, mSBI, BOP significantly higher NKM group. both...

The mechanisms involved in the initiation and progression of peri-implantitis lesions are poorly understood. It was aim to determine content activation status macrophages present human compare current findings with macrophage polarization associated periodontitis lesions.A total 14 patients were studied this investigation. Seven soft tissue biopsies from dental implants affected by that required explantation. chronic periodontal disease. Immunofluorescence stains performed using biomarkers...

Tooth extraction results in alveolar bone resorption and is accompanied by postoperative swelling pain. Maresin 1 (MaR1) a proresolving lipid mediator produced macrophages during the resolution phase of inflammation, bridging healing tissue regeneration. The aim this study was to examine effects MaR1 on tooth socket wound preclinical rat model. maxillary right first molars Sprague-Dawley rats were extracted, gelatin scaffolds placed into sockets with or without MaR1. Topical application also...

An association between vitamin D deficiency and early dental implant failure is not properly verified, but its role in osteoimmunology discussed. This article illustrates two case reports with failure. Prior to placement, the first patient received crestal bone grafting autologous material. Both patients implants from different manufacturers molar region of mandible. In patient, all were placed a two-stage procedure. All had be removed within 15 days after placement. Vitamin serum levels...

Abstract Periodontal disease destroys supporting structures of teeth. However, tissue engineering strategies offer potential to enhance regeneration. Here, the patterned topography, spatiotemporally controlled growth factor gene delivery, and cell‐based therapy repair bone–periodontal ligament (PDL) interfaces are combined. Micropatterned scaffolds fabricated for regions using polycaprolactone (PCL)/polylactic‐ co ‐glycolic acid combined with amorphous PCL bone region. Scaffolds modified...

Degradation of the implant surface and particle release/formation as an inflammation catalyst mechanism is emerging concept in dental medicine that may help explain pathogenesis peri-implantitis. The aim present study was a synchrotron-based characterization micro- nanosized implant-related particles inflamed human tissues around titanium ceramic implants exhibited signs Size, distribution, chemical speciation exogenous content were evaluated using synchrotron μ-X-ray fluorescence...

ABSTRACT Objective Abaloparatide (ABL) is a synthetic parathyroid hormone‐related protein analog developed as an anabolic drug to treat osteoporosis. ABL increases bone mineral density (BMD) of the long bones and spine; however, influence on alveolar regeneration remains unknown. This study assessed effects systemic administration tooth extraction socket healing dental implant osseointegration in preclinical rodent model. Methods Sprague‐Dawley rats received daily subcutaneous injection (25...

Our study aim was to compare allogeneic cancellous bone (ACB) and synthetic or highly-processed xenogeneic substitutes (SBS) in the treatment of skeletal defects orthopedic surgery. 232 patients treated for bony lesions with ACB (n = 116) SBS within a 10-year time period were included this case–control study. Furthermore, both materials seeded human osteoblasts (hOB, n 10) analyzed by histology, viability (AlamarBlue®) protein expression activity (Luminex®). The complication rate 14.2 %,...

Dental implants are an important option for replacement of missing teeth. A major clinical challenge is how best to accelerate bone regeneration and reduce the healing time functional restoration after implant placement. sclerostin-neutralizing antibody (Scl-Ab) has been shown enhance alveolar formation fracture repair. The aim this study was investigate effects systemic administration Scl-Ab on dental osseointegration in experimental ridge tooth extraction model.To osseointegration,...

Titanium (Ti) is considered bioinert and still regarded as the "gold standard" material for dental implants. However, even 'commercial pure' Ti will contain minor fractions of elemental impurities. Evidence demonstrating release ions particles from 'passive' implant surfaces increasing has been attributed to biocorrosion processes which may provoke immunological reactions. observed in peri-implant tissues shown be co-located with elements impurities biomedical alloys. Accordingly, this study...

Abstract Dental implants have been established as successful treatment options for missing teeth with steadily increasing demands. Today, the primary areas of research in dental implantology revolve around osseointegration, soft and hard tissue grafting well peri‐implantitis diagnostics, prevention, treatment. This review provides a comprehensive overview current literature on application MS‐based proteomics implant research, highlights how explorative provided insights into biology...

This article unveils a case of the classic styloid syndrome and states that panoramic imaging ultrasound can be an alternative to computed tomography. In addition, endoscope-assisted extraoral approach using CT-based navigation is useful. Eagle's Syndrome aggregate symptoms described by Eagle in 1937. He different forms: consisting elongation process which causes pain. Second, stylo-carotid-artery responsible for transient ischemic attack or stroke.Using example 66 years old male patient...

The interest in ceramic dental implants made of yttria-stabilized tetragonal zirconia polycrystals (Y-TZP) or alumina toughened (ATZ) has increased recent years. However, the light aging, corrosion, and potential impurities ceramics, material composition these associated term "metal-free" is persistently questioned. Thus, present study aimed to conduct an elemental analysis commercial specify their identify contaminants.Nine implant systems corresponding samples were analyzed using...