A5101469308- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Inflammatory Biomarkers in Disease Prognosis
- Autophagy in Disease and Therapy
- Cancer Research and Treatments
- CAR-T cell therapy research
- Immune cells in cancer
- Cancer Cells and Metastasis
- interferon and immune responses
- Mycobacterium research and diagnosis
- Muscle and Compartmental Disorders
- Eosinophilic Disorders and Syndromes
- Immune Response and Inflammation
- RNA Research and Splicing
- Pain Mechanisms and Treatments
- Lymphoma Diagnosis and Treatment
- Botulinum Toxin and Related Neurological Disorders
- Cancer Genomics and Diagnostics
- Chemotherapy-related skin toxicity
- Conservation Techniques and Studies
- Genetic factors in colorectal cancer
Universidad Católica San Antonio de Murcia
2018-2024
Instituto Murciano de Investigación Biosanitaria
2018-2024
Hospital General Universitario Morales Meseguer
2009-2024
Weill Cornell Medicine
2020
Cornell University
2020
Centro Regional de Hemodonación
2015-2019
Angiogenesis is a key process for tumor progression and target treatment. However, the regulation of breast cancer angiogenesis its relevance clinical resistance to antiangiogenic drugs still incompletely understood. Recent developments on contribution microRNA oncogenic effects miR-17-92, miRNA cluster, point their potential role angiogenesis. The aim this work was establish miR-20a, member miR-17-92 in patients with invasive carcinoma.Tube-formation vitro assays conditioned medium from...
Peripheral blood lymphocyte (PBL) count may reflect the immune status of cancer patients. We retrospectively analyzed predictive and prognostic impact baseline post-chemotherapy PBL counts in a homogeneous group 103 breast patients treated with neoadjuvant chemotherapy (anthracyclines taxanes). In univariate analysis, under 1500 × 106/L (p = 0.013; hazard ratio [HR]: 2.80, 95%CI 1.24–6.61), decrease >200 after first cycle 0.047; HR: 2.82, 1.01–7.86) were significantly related to disease free...
En sus etapas iniciales, la conservación de los sitios arqueológicos tuvo un carácter reactivo, en que las intervenciones estaban encaminadas a paliar daños producidos por diferentes causas y devolverlos su estado más próximo al original. Más adelante, gracias incorporación disciplina preventiva, van precedidas una identificación impactos consisten unas medidas que, con proactivo, tienen como objetivo futuros deterioros. Las amenazas derivadas cambio climático suponen reto el primer lugar,...
Focal radiotherapy can promote cross-presentation of tumor antigens to T cells, but by itself, it is insufficient induce therapeutically effective T-cell responses. The common gamma-chain cytokine IL15 promotes and sustains the proliferation effector function CD8+ cells has limited activity against poorly immunogenic tumors that do not elicit significant spontaneous Here, we show subcutaneous had complementary effects induced T-cell-mediated regression long-term protective memory responses...
Purpose: Although diabetes mellitus (DM) is recognized as a risk factor for chemotherapy-induced neurotoxicity, its true impact on intensity and time course of peripheral neuropathy still unclear. The goal was to analyze the relevance preexisting DM weekly paclitaxel-induced (PIPN). Methods: We performed retrospective case-control study (1:2) including total 129 patients with breast cancer (43 86 controls) treated single-agent paclitaxel (wP). Results: Compared controls, wP experienced PIPN...
While the role of miR-200c in cancer progression has been established, its expression and prognostic breast is not completely understood. The predictive response to chemotherapy also suggested by some studies, but only limited clinical evidence available. purpose this study was investigate miR-200c-3p plasma primary tumor BC patients. design included two cohorts involving women with locally advanced (LABC) metastatic cancer. Tumor samples were obtained before after treatment. We found that...
Abstract Purpose The prognostic utility and biological correlates of neutrophil to lymphocyte ratio (NLR), a potential biomarker the balance between immune response inflammatory status, are still uncertain in breast cancer (BC). Methods We analysed cohort 959 women with early cancer, mostly treated neoadjuvant or adjuvant chemotherapy. Clinical pathological data, survival, NLR (continuous categorical) stromal tumor infiltrating lymphocytes (sTIL) were evaluated. Results was only weakly...
Luminal breast cancer (BC) is associated with less immune activation, and the significance of stromal lymphocytic infiltration (sTIL) more uncertain than in other BC subtypes. The aim this study was to investigate predictive prognostic value sTIL early luminal BC. performed an observational design a prospective cohort 345 patients predominantly high-risk (hormone receptor positive, HER2 negative) B features (n = 286), which presence analyzed validated methods. Median 5% (Q1-Q3 range (IQR),...
Autophagy supports both cellular and organismal homeostasis. However, whether autophagy should be inhibited or activated for cancer therapy remains unclear. Deletion of essential genes increased the sensitivity mouse breast carcinoma cells to radiation (RT), in vitro vivo (in immunocompetent syngeneic hosts). Autophagy-deficient secreted amounts type I interferon (IFN), which could limited by CGAS STING knockdown, mitochondrial DNA (mtDNA) depletion. In vivo, irradiated autophagy-incompetent...
<p>Supplementary Figures 1-4</p>
<p>Supplementary Figures 1-4</p>
Abstract Background: Endocrine resistance is a major cause of therapeutic failure in metastatic breast cancer (MBC). The information provided by DNA sequencing plasma cell free (cfDNA) and the analysis circulating tumor cells (CTC) may be useful to determine occurrence type endocrine resistance. However, different levels concordance between cfDNA CTC, also liquid biopsy tissue biopsy, have been reported. Thus, best strategy for performing setting decisions luminal MBC patients not well...