A5090216911- Gene Regulatory Network Analysis
- Bioinformatics and Genomic Networks
- Genetics, Bioinformatics, and Biomedical Research
- Scientific Computing and Data Management
- Mathematical Biology Tumor Growth
- Evolution and Genetic Dynamics
European Bioinformatics Institute
2019-2021
Wellcome Trust
2019
Computational modelling has become increasingly common in life science research. To provide a platform to support universal sharing, easy accessibility and model reproducibility, BioModels (https://www.ebi.ac.uk/biomodels/), repository for mathematical models, was established 2005. The current allows submission of models encoded diverse formats, including SBML, CellML, PharmML, COMBINE archive, MATLAB, Mathematica, R, Python or C++. submitted are curated verify the computational...
Reproducibility of scientific results is a key element science and credibility. The lack reproducibility across many fields has emerged as an important concern. In this piece, we assess mathematical model propose scorecard for improving in field.
Abstract The reproducibility crisis has emerged as an important concern across many fields of science including life science, since published results failed to reproduce. Systems biology modelling, which involves mathematical representation biological processes study complex system behaviour, was expected be least affected by this crisis. While lack experimental and computational analysis could a repercussion several compounded factors, it not fully understood why systems models with...