A5028834264- Pregnancy and preeclampsia studies
- Gene Regulatory Network Analysis
- Preterm Birth and Chorioamnionitis
- Global Maternal and Child Health
- Bioinformatics and Genomic Networks
- Maternal and Neonatal Healthcare
- Cancer-related molecular mechanisms research
- Scientific Computing and Data Management
- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Evolution and Genetic Dynamics
- MicroRNA in disease regulation
- Mathematical Biology Tumor Growth
- Genetics, Bioinformatics, and Biomedical Research
- Circular RNAs in diseases
- Maternal and Perinatal Health Interventions
- Gestational Diabetes Research and Management
Indian Institute of Technology Madras
2020-2024
European Bioinformatics Institute
2019-2021
Wellcome Trust
2019
Computational modelling has become increasingly common in life science research. To provide a platform to support universal sharing, easy accessibility and model reproducibility, BioModels (https://www.ebi.ac.uk/biomodels/), repository for mathematical models, was established 2005. The current allows submission of models encoded diverse formats, including SBML, CellML, PharmML, COMBINE archive, MATLAB, Mathematica, R, Python or C++. submitted are curated verify the computational...
Reproducibility of scientific results is a key element science and credibility. The lack reproducibility across many fields has emerged as an important concern. In this piece, we assess mathematical model propose scorecard for improving in field.
Abstract Background Different formulae have been developed globally to estimate gestational age (GA) by ultrasonography in the first trimester of pregnancy. In this study, we develop an Indian population-specific dating formula and compare its performance with published formulae. Finally, evaluate implications choice method on preterm birth (PTB) rate. This study’s data was from GARBH-Ini, ongoing pregnancy cohort North women study PTB. Methods Comparisons between ultrasonography-Hadlock...
Abstract The reproducibility crisis has emerged as an important concern across many fields of science including life science, since published results failed to reproduce. Systems biology modelling, which involves mathematical representation biological processes study complex system behaviour, was expected be least affected by this crisis. While lack experimental and computational analysis could a repercussion several compounded factors, it not fully understood why systems models with...
A large proportion of pregnant women in lower and middle-income countries (LMIC) seek their first antenatal care after 14 weeks gestation. While the last menstrual period (LMP) is still most prevalent method determining gestational age (GA), ultrasound-based foetal biometry considered more accurate second third trimesters. In LMIC settings, Hadlock formula, originally developed using data from a small Caucasian population, widely used for estimating GA weight worldwide as pre-programmed...
Abstract Background Different formulae have been developed globally to estimate gestational age (GA) by ultrasonography in the first trimester of pregnancy. In this study, we develop an Indian population-specific dating formula and compare its performance with published formulae. Finally, evaluate implications choice method on preterm birth (PTB) rate. This study’s data was from GARBH-Ini, ongoing pregnancy cohort North women study PTB. Methods Comparisons between ultrasonography-Hadlock...
Abstract Background The prevalence of preterm birth (PTB) is high in lower and middle-income countries (LMIC) such as India. In LMIC, since a large proportion seeks antenatal care for the first time beyond 14-weeks pregnancy, accurate estimation gestational age (GA) using measures derived from ultrasonography scans second third trimesters paramount importance. Different models have been developed globally to estimate GA, currently, LMIC uses Hadlock’s formula data based on North American...
Abstract Purpose We aimed to identify the epithelial-mesenchymal transition and associated putative targets of miR-34 family in transcriptomic data cervical epithelial squamous cell carcinoma (CESC) find new therapeutic for better disease management. Methods A combined computational analysis family; gene expression heterogeneous primary CESCs derived from TCGA; integration miR-34b EMT-regulated genes was performed. Four EMT-associated were analysed human CESC non-cancerous tissues by...