A5025895146- Hippo pathway signaling and YAP/TAZ
- Wnt/β-catenin signaling in development and cancer
- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- COVID-19 and Mental Health
- Infection Control and Ventilation
- COVID-19 epidemiological studies
- Mental Health and Patient Involvement
- Cancer-related molecular mechanisms research
- Multiple and Secondary Primary Cancers
- Urban, Neighborhood, and Segregation Studies
- Glioma Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Posttraumatic Stress Disorder Research
- Healthcare innovation and challenges
- Mental Health Treatment and Access
- Homelessness and Social Issues
- Cancer-related Molecular Pathways
- Health, psychology, and well-being
- History and advancements in chemistry
- Science, Research, and Medicine
- Global Health Workforce Issues
- demographic modeling and climate adaptation
- Migration, Health and Trauma
Cambridgeshire and Peterborough NHS Foundation Trust
2024
Centre National de la Recherche Scientifique
2023
Université de Caen Normandie
2023
Normandie Université
2023
Louisiana State University Health Sciences Center New Orleans
2023
Imagerie et Stratégies Thérapeutiques pour les Cancers et Tissus cérébraux
2023
University of East Anglia
2023
University of North Carolina at Chapel Hill
2020-2021
Washington University in St. Louis
2010-2019
Centre for Mental Health
2015
Few studies have described changes in SARS-CoV-2 antibody levels response to infection and vaccination at frequent intervals over extended follow-up periods. The purpose of this study was assess SARS-CoV-2-specific responses among a prospective cohort health care personnel 18 months with up 22 samples per person. Antibody live virus neutralization were measured before after mRNA-based results stratified by (1) status prior initial (2) any point during follow-up. We found that the first dose...
High-quality research in clinical psychology often depends on recruiting adequate samples of participants with formally diagnosed difficulties. This challenge is readily met within the context a large treatment center, but many researchers work academic settings that do not feature medical school, hospital connections, or an in-house clinic. article describes model we developed at University Waterloo Centre for Mental Health Research identifying and people from local communities diagnosable...
Abstract The molecular mechanisms induced by hypoxia are misunderstood in non-small cell lung cancer (NSCLC), and above all the RASSF1A/Hippo signaling relationship. We confirmed that human NSCLC ( n = 45) as their brain metastases (BM) counterpart hypoxic since positive with CAIX-antibody (target gene of Hypoxia-inducible factor (HIF)). A severe prolonged (0.2% O2, 48 h) activated YAP (but not TAZ) Human Bronchial Epithelial Cells (HBEC) lines downregulating RASSF1A/kinases Hippo (except...
The prognosis for patients with non‑small cell lung cancer (NSCLC), a type which represents 85% of all cancers, is poor 5‑year survival rate 19%, mainly because NSCLC diagnosed at an advanced and metastatic stage. Despite recent therapeutic advancements, ~50% will develop brain metastases (BMs). Either surgical BM treatment alone symptomatic single cerebral metastases, or in combination stereotactic radiotherapy (RT) who are not suitable surgery presenting fewer than four lesions diameter...
Background Health care personnel (HCP) are at high risk for exposure to the SARS-CoV-2 virus. While personal protective equipment (PPE) may mitigate this risk, prospective data collection on its use and other factors seroconversion in population is needed. Objective The primary objectives of study (1) determine incidence of, for, infection among HCP a tertiary medical center (2) actively monitor PPE use, interactions between participants via electronic sensors, secondary cases households,...
Aims Referrals for adult autism assessment to the Cambridgeshire Lifespan Autism Spectrum Service (CLASS) have increased from 430 in 2019 887 2023, with demand exceeding capacity. The team enrolled Royal College of Psychiatrists’ Quality Improvement (QI) Demand, Capacity and Flow (DCF) Collaborative. agreed aim was increase number diagnostic assessments by 51% per month. Methods Participants included CLASS multi-disciplinary (MDT), referrers, provider improvement advisor an autistic adult....
<sec> <title>BACKGROUND</title> Health care personnel (HCP) are at high risk for exposure to the SARS-CoV-2 virus. While personal protective equipment (PPE) may mitigate this risk, prospective data collection on its use and other factors seroconversion in population is needed. </sec> <title>OBJECTIVE</title> The primary objectives of study (1) determine incidence of, for, infection among HCP a tertiary medical center (2) actively monitor PPE use, interactions between participants via...
Abstract The molecular mechanisms induced by hypoxia are misunderstood in non-small cell lung cancer (NSCLC), and above all the RASSF1A/Hippo signaling relationship. We confirmed that human NSCLC (n=45) as their brain metastases (BM) counterpart hypoxic since positive with CAIX-antibody (target gene of Hypoxia-inducible factor (HIF)). A severe prolonged (0.2% O2, 48h) activated YAP (but not TAZ) Human Bronchial Epithelial Cells (HBEC) lines downregulating RASSF1A/kinases Hippo (except for...