A5025602195- Porphyrin and Phthalocyanine Chemistry
- Photodynamic Therapy Research Studies
- Supramolecular Chemistry and Complexes
- Nanoplatforms for cancer theranostics
- Oxidative Organic Chemistry Reactions
- Microplastics and Plastic Pollution
- Luminescence and Fluorescent Materials
- Luminescence Properties of Advanced Materials
- Synthesis of Organic Compounds
- Molecular Sensors and Ion Detection
- Photochromic and Fluorescence Chemistry
- Occupational Health and Safety in Workplaces
- Photoreceptor and optogenetics research
- Business, Innovation, and Economy
- Marine and coastal ecosystems
- Advanced NMR Techniques and Applications
- Radical Photochemical Reactions
- Crystallography and molecular interactions
- Advanced Photocatalysis Techniques
Universidad de Panamá
2019-2025
Secretaría Nacional de Ciencia, Tecnología e Innovación
2022-2025
Pontificia Universidad Católica de Chile
2016-2021
Rede de Química e Tecnologia
2016
Abstract Toluidine blue O (TBO) is a type I–type II photosensitizer that has shown good efficacy and selectivity in antimicrobial anticancer photodynamic therapy applications. However, its complex photochemistry with multiple photoproducts hinders application as photosensitizer. We have previously described the mechanism for photooxidative demethylation of TBO which acetonitrile yields two main products: demethylated‐TBO (d‐TBO) double‐demethylated‐TBO (dd‐TBO). In current work, we describe...
Biosupramolecular assemblies combining cucurbit[n]urils (CB[n]s) and proteins for the targeted delivery of drugs have potential to improve photoactivity photosensitizers used in photodynamic therapy cancer. Understanding complexity these systems how it affects properties is focus this work. We acridine orange (AO+) as a model photosensitizer compared with methylene blue (MB+) cationic porphyrin (TMPyP4+). Encapsulation into CB[n]s (n = 7, 8) modified their photoactivity. In particular, AO+,...
A novel strategy to control the generation of singlet oxygen by a photosensitizer using cucurbit[n]urils inclusion complexes is shown herein, and has great potential for therapeutic applications. We show basic requirements in order develop an on–off switch that reversible competitive binding. The supramolecular proposed this paper avoids complex synthetic schemes activate or deactivate as previous work supports use biocompatible materials. Mechanistic insights into over are provided, which...
Abstract Cucurbit[ n ]urils (CB[ ]s) have emerged as potential candidates for drug delivery in several areas due to their strong binding interactions and low toxicity. More recently, benefits a type of cancer treatment termed Photodynamic Therapy (PDT) been recognized. The outcomes this therapy rely on better strategies improving overall photoactivity the drugs, which is where CB[ ]s could impact. effects these molecular containers are discussed new interesting work highlighted.
The formation of inclusion complexes between drugs and macrocycles has proven to be an effective strategy increase solubilization stabilization the drug, while in several cases improving their biological activity. In this context, we explored complex chemotherapeutic drug Melphalan (Mel) cucurbit[7]uril (CB[7]), studied its effect on Mel alkylating activity, hydrolysis, cytotoxicity. (Mel@CB[7]) was by absorption fluorescence spectroscopy, NMR, docking studies, molecular dynamics...
Experiments and theoretical calculations by density functional theory (DFT) have been carried out to examine a self-sensitized type I photooxidation of toluidine blue O (TBO+). This study attempts build connection between visible-light photolysis demethylation processes methylamine compounds, such as TBO+. We show that controlled photoinduced mono- double-demethylation TBO+ can be achieved. The kinetics for the appearance rate mono-demethylated double-demethylated were found fit...
Toluidine blue O (TBO) is a water-soluble photosensitizer that has been used in photodynamic antimicrobial and anticancer treatments, but suffers from limited solubility hydrophobic media. In an effort to incrementally increase TBO's hydrophobicity, we describe the synthesis of hexanoic (TBOC6) myristic (TBOC14) fatty acid derivatives TBO formed low moderate percent yields by condensation with free amine site. Covalently linking 6 14 carbon chains led modifications not only solubility, also...
We report on the formation of toluidine blue O (TBO) sulfoxide by a self-sensitized photooxidation TBO. Here, photosulfoxidation process was studied mass spectrometry (MS) and discussed in context photodemethylation processes which both contribute to TBO consumption over time. Analysis solvent effects with D
Este trabajo aborda la problemática representada por los micro y nanoplásticos (MP NP, respectivamente) en las costas americanas del Océano Pacífico, desde perspectiva de Red Micro Nano Allpa Pacha. Esta red está conformada científicos Chile, Perú, Costa Rica, Colombia, Ecuador, Panamá México, quienes, preocupados el impacto ambiente su repercusión salud, decidieron establecer colaboraciones científicas internacionales para geolocalización, monitoreo caracterización MP NP presentes Pacífico...
Desde su origen en la década de los años 50’s, plásticos se han convertido un material omnipresente vida diaria nuestras sociedades. A pesar amplia gama usos, lenta degradación estos materiales el ambiente ha ocasionado problema contaminación emergente consecuencias aún desconocidas. El objetivo esta revisión es evaluar impacto que tenido introducción microplásticos nuestros ecosistemas. Reportes recientes indican presencia extendido hasta ambientes prístinos como polos del planeta. La...