A5064052379- Plant Pathogens and Fungal Diseases
- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Plant biochemistry and biosynthesis
- Marine Sponges and Natural Products
- Natural product bioactivities and synthesis
- Biological Stains and Phytochemicals
- Species Distribution and Climate Change
- Phytochemical compounds biological activities
- Coral and Marine Ecosystems Studies
- Metabolomics and Mass Spectrometry Studies
- Plant and fungal interactions
- Medicinal Plants and Neuroprotection
- Vibrio bacteria research studies
- Photodynamic Therapy Research Studies
- Seaweed-derived Bioactive Compounds
- Plant-Microbe Interactions and Immunity
- Alkaloids: synthesis and pharmacology
- Aquaculture disease management and microbiota
- Isotope Analysis in Ecology
- Plant-Derived Bioactive Compounds
- Antioxidant Activity and Oxidative Stress
- Analytical Chemistry and Chromatography
- Bacterial Identification and Susceptibility Testing
- Bioactive Compounds and Antitumor Agents
Universidad de Panamá
2003-2025
Acharya Nagarjuna University
2015-2018
Instituto de Investigaciones Científicas y Servicios de Alta Tecnología
2014-2018
City of Knowledge
2007-2016
Exact Sciences (United States)
2007
Oregon State University
2007
Scripps Institution of Oceanography
2007
Smithsonian Tropical Research Institute
2003-2006
Secretaría Nacional de Ciencia, Tecnología e Innovación
2006
Florida State University-Panama
2003
Coral reefs are intricate ecosystems that harbor diverse organisms, including 25% of all marine fish. Healthy corals exhibit a complex symbiosis between coral polyps, endosymbiotic alga, and an array microorganisms, called the holobiont. Secretion specialized metabolites by microbiota is thought to contribute defense this sessile organism against harmful biotic abiotic factors. While few causative agents diseases have been unequivocally identified, fungi implicated in massive destruction...
Five novel cassane diterpenes (1-5) with activity against Trypanosoma cruzi were isolated from leaves of Myrospermum frutescens. The structures determined as 18-hydroxycassan-13,15-diene (1), 6beta,18-dihydroxycassan-13,15-diene (2), 6beta-hydroxy-18-acetoxycassan-13,15-diene (3), 18-acetoxy-13,15-diene-19-cassanoic acid (4), and 6beta,13beta-dihydroxy-18-acetoxycassan-14(17),15-diene (5). Structures elucidated by spectroscopic analysis (NMR HRCIMS) the synthesis derivatives 2a 2b. Compounds...
Three new flavonol arabinosides (2−4) were isolated from the young leaves of Calycolpus warszewiczianus. The structures determined as myricetin-3-O-α-l-3' '-acetylarabinofuranoside (2), ',5' '-diacetylarabinofuranoside (3), and 5-galloylquercetin-3-O-α-l-arabinofuranoside (4). Molecular elucidated using NMR spectroscopy in combination with IR MS data. Two known compounds, myricetin-3-O-α-l-arabinofuranoside (1) (−)-epi-catechin (5), also isolated. compounds tested vitro against a...
Two new compounds, 5-(11'(S)-hydroxy-8'-heptadecenyl)resorcinol (3) and 5-(12'(S)-hydroxy-8',14'-heptadecadienyl)resorcinol (4), were isolated from the leaves of Stylogyne turbacensis together with known analogue metabolites 1 2. Compounds 3 4 showed strongest activity in leishmania assay, 7 μM, respectively, while compounds 1, 2, moderate against a drug-resistant strain Trypanosoma cruzi IC50 values 30, 25, 22 respectively. Additional testing MCF-7 NCI-H460 was performed for 4. The...
As a result of the capability fungi to respond culture conditions, we aimed explore and compare antibacterial activity chemical diversity two endophytic isolated from Hyptis dilatata cultured under different conditions by addition elicitors, changes in pH, incubation temperatures. Seventeen extracts were obtained both Pestalotiopsis mangiferae (man-1 man-17) microspora (mic-1 mic-17) tested against panel pathogenic bacteria. Seven P. four showed activity; while some these displayed...
Four new diterpenes (1−4) were isolated from the leaves of Myrospermum frutescens as minor constituents. Chagresnol (1), 6β,18-diacetoxycassan-13,15-diene (2), and chagreslactone (3) possess cassane skeletons, while chagresnone (4) exhibits a cleistanthane skeleton. Molecular structures their relative stereochemistries elucidated using NMR spectroscopy in combination with UV, IR, MS spectral data. Although compound 2 was previously reported synthetic product, we report its first isolation...
Chemical examination of the octocoral-associated Bacillus species (sp.) DT001 led to isolation pumilacidins A (1) and C (2). We investigated effect these compounds on viability Plasmodium falciparum mechanism pumilacidin-induced death. The use inhibitors protein kinase (PKC) phosphoinositide 3-kinase (PI3K) was able prevent effects C. results indicated also that inhibit parasite growth via mitochondrial dysfunction decreased cytosolic Ca2+.
Three new diterpenes, uprolide N (1), O (2), P (3) and a known one, dolabellane (4), were isolated from the CH₂Cl₂-MeOH extract of gorgonian octocoral Eunicea succinea, collected Bocas del Toro, on Caribbean coast Panama. Their structures determined using spectroscopic analyses, including 1D 2D NMR high-resolution mass spectrometry (HRMS) together with molecular modeling studies. Compounds 1-3 displayed anti-inflammatory properties by inhibiting production Tumor Necrosis Factor (TNF)...
Lasiodiplodia is a widely distributed fungal genus, frequently found in tropical and subtropical regions where it can cause disease important crops. It represents promising source of active secondary metabolites with uses chemical, pharmaceutical, agrochemical processes. In this study, the strain iranensis F0619 was isolated from mangrove Avicennia ger-minans, collected Sarigua National Park Republic Panama. Fractions crude extract were analyzed by UPLC-ESI-MS/MS, five compounds, previously...
We report on the formation of toluidine blue O (TBO) sulfoxide by a self-sensitized photooxidation TBO. Here, photosulfoxidation process was studied mass spectrometry (MS) and discussed in context photodemethylation processes which both contribute to TBO consumption over time. Analysis solvent effects with D
The 9´Z-bixin is the major pigment present in annatto (Bixa orellana L.) seeds. Other carotenoids seeds of are 9´Z-norbixin and 9´Z-methylbixin. Annatto extract used as a food colorant. In this study, we extracted isolated from 9’Z-norbixin was obtained purified by saponification extract. Then, 9’Z-methylbixin Steglich esterification with EDC/DMAP. Also, all E-methylbixin 9’Z-bixin acid conditions hydrochloric methanol. antioxidant capacity bixin derivatives measured ABTS assay to determine...
ADVERTISEMENT RETURN TO ISSUEPREVErratumNEXTORIGINAL ARTICLEThis notice is a correctionNovel Cassane and Cleistanthane Diterpenes from Myrospermum frutescens: Absolute Stereochemistry of the Diterpene Series.Daniel Torres-Mendoza, Luis David Ureña González, Eduardo Ortega-Barría, Phyllis D. Coley, Thomas A. Kursar, Todd L. Capson, Kerry McPhail, Cubilla-RiosCite this: J. Nat. Prod. 2006, 69, 8, 1256Publication Date (Web):July 25, 2006Publication History Published online25 July 2006Published...