A5070751477- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Ubiquitin and proteasome pathways
- Retinal Diseases and Treatments
- Phosphodiesterase function and regulation
- Neuroscience and Neuropharmacology Research
- Carbohydrate Chemistry and Synthesis
- Microbial Natural Products and Biosynthesis
- Peptidase Inhibition and Analysis
- Receptor Mechanisms and Signaling
- Photochromic and Fluorescence Chemistry
- Click Chemistry and Applications
- Synthetic Organic Chemistry Methods
- Marine Sponges and Natural Products
- Biochemical and Molecular Research
- Histone Deacetylase Inhibitors Research
- Cancer Mechanisms and Therapy
- Synthesis and Catalytic Reactions
- Neuroscience and Neural Engineering
- Chemical synthesis and alkaloids
- interferon and immune responses
- Zebrafish Biomedical Research Applications
- PARP inhibition in cancer therapy
- Cytomegalovirus and herpesvirus research
- bioluminescence and chemiluminescence research
Biolog Life Science Institute
2014-2024
Leibniz University Hannover
2010-2013
Helmholtz Centre for Infection Research
2012-2013
Significance Development of treatments for hereditary degeneration the retina (RD) is hampered by vast genetic heterogeneity this group diseases and delivery drug to an organ protected blood–retina barrier. Here, we present approach treatment different types RD, combining innovative therapy with a liposomal system that facilitates into retina. Using animal models RD show pharmacological preserved both viability cells in as well retinal function. Thus, our study provides avenue development...
Leading the way: The synthesis of natural products with new biological targets is one driving forces for development antibiotics. two secondary metabolites corallopyronin and myxopyronin (see picture) have been achieved, which are prominent leads inhibition bacterial RNA polymerase. Detailed facts importance to specialist readers published as ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by authors. Please note:...
Drug resistance mechanisms still characterize metastatic melanoma, despite the new treatments that have been recently developed. Targeting of cGMP/protein kinase G pathway is emerging as a therapeutic approach in cancer research. In this study, we evaluated anticancer effects two polymeric-linked dimeric cGMP analogs able to bind and activate protein G, called activators (PAs) 4 5. PA5 was identified most effective compound on melanoma cell lines well patient-derived cells cultured...
Hereditary retinal degeneration (RD) is often associated with excessive cGMP signalling in photoreceptors. Previous research has shown that inhibition of cGMP-dependent protein kinase G (PKG) can reduce photoreceptor loss two different RD animal models. In this study, we identified a PKG inhibitor, the analogue CN238, which preserved viability and functionality rd1 rd10 mutant mice. Surprisingly, explanted retinae, CN238 also protected ganglion cells from axotomy-induced retrograde their...
Azido sugars hold great promise as substrates in numerous click-chemistry applications. However, the synthesis of activated azido is limited by cost and complexity. Conventional chemical activation methods are intricate time-consuming. In response, we have developed a process for large-scale production UDP-6-azido-GalNAc through enzymatic nucleotide sugar on gram scale. Our optimization strategies encompassed refining parameters an enzyme cascade featuring NahK from Bifidobacterium longum...
Argyrin F unfolds its promising antitumor activity twice: First through stabilization of the tumor suppressor protein p27 and second by vascular damage. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted authors. Please note: The publisher is responsible for content functionality any supporting information supplied Any queries (other than missing content) should...
Abstract Schon kurz nach der Entdeckung des Proteasoms war klar, dass Proteasom‐Inhibitoren in Lage sein sollten, Proteine zu stabilisieren, die zur Apoptose von Tumorzellen führen sollten. Die entscheidenden Fragen dabei war, ob es prinzipiell überhaupt möglich ist, das Proteasom inhibieren, ohne untragbare Nebenwirkungen hervorzurufen, und wie man solchen Inhibitoren gelangen könnte. Glücklicherweise stellt “Mutter Natur” eine ganze Bandbreite verschiedenen Naturstoffen Verfügung, selektiv...
Melanoma is one of the most aggressive cancers and displays high resistance to conventional chemotherapy underlining need for new therapeutic strategies. The cGMP/PKG signaling pathway was detected in melanoma cells shown reduce migration, proliferation increase apoptosis different cancer types. In this study, we evaluated effects on cell viability, death, migration novel dimeric cGMP analogues two lines (MNT1 SkMel28). These analogues, by activating PKG with limited PKA, significantly...
Die Synthese von Naturstoffen mit neuartigen biologischen Targets ist eine der Voraussetzungen für die Entwicklung neuer Antibiotika. beiden Sekundärmetabolite Corallopyronin und Myxopyronin wurden synthetisiert, als vielversprechende Leitstrukturen zur Inhibierung bakteriellen RNA-Polymerase gelten.
Poly-ADP-ribose-polymerase (PARP) relates to a family of enzymes that can detect DNA breaks and initiate repair. While this activity is generally seen as promoting cell survival, PARP are also known be involved in death numerous pathologies, including inherited retinal degeneration. This ambiguous role makes it attractive have simple fast enzyme assay, allows resolving its enzymatic situ, individual cells, within complex tissues. A previously published two-step assay uses biotinylated NAD+...
Abstract Hereditary retinal degeneration (RD) is often associated with excessive cGMP-signaling in photoreceptors. Previous research has shown that inhibition of cGMP-dependent protein kinase G (PKG) can slow down the loss photoreceptors different RD animal models. In this study, we identified a novel PKG inhibitor, cGMP analogue CN238, strong protective effects on rd1 and rd10 mutant mice. long-term organotypic explants, CN238 preserved photoreceptor viability function. Surprisingly,...
The vertebrate retina harbors rod and cone photoreceptors. Human vision critically depends on photoreceptor function. In the phototransduction cascade, cGMP activates distinct isoforms of cyclic nucleotide-gated (CNG) channel. Excessive levels initiate a pathophysiological rollercoaster, which starts with CNG channel over-activation, typically in This triggers cell death rods first, then cones, is root cause many blinding retinal diseases, including Retinitis pigmentosa. While targeting...
Abstract Cyclic nucleotide-gated (CNG) channels play an essential role within the phototransduction cascade in vertebrates. Although rod and cone light responses are mediated through similar pathways, each photoreceptor type relies on a specific CNG-channel isoform. In many forms of retinal degeneration, increased cGMP levels initiate pathophysiological rollercoaster, which starts with enhanced activation, often photoreceptors. This causes cell death both rods cones, eventually leads to...
I.N. is not a corresponding author of this paper, rather L.B and contributed equally to work.
Abstract Review: ca. 300 refs.