A5023306271- Lipid Membrane Structure and Behavior
- Immune Response and Inflammation
- Streptococcal Infections and Treatments
- Oral microbiology and periodontitis research
- Bacterial Genetics and Biotechnology
- RNA and protein synthesis mechanisms
- Bacterial Infections and Vaccines
- Machine Learning in Bioinformatics
- Carbohydrate Chemistry and Synthesis
- Antimicrobial Peptides and Activities
- Toxoplasma gondii Research Studies
- Polymer Surface Interaction Studies
- Supramolecular Self-Assembly in Materials
- Block Copolymer Self-Assembly
- Force Microscopy Techniques and Applications
- Escherichia coli research studies
- Advanced Materials and Mechanics
- Pneumocystis jirovecii pneumonia detection and treatment
- Orthopedic Infections and Treatments
- Micro and Nano Robotics
Lehigh University
2015-2018
Rutgers, The State University of New Jersey
2013
The Gram-negative bacterium, Aggregatibacter actinomycetemcomitans, has been associated with localized aggressive periodontitis (LAP). In particular, highly leukotoxic strains of A. actinomycetemcomitans have more closely this disease, suggesting that LtxA is a key virulence factor for actinomycetemcomitans. secreted across both the inner and outer membranes via Type I secretion system, but also found to be enriched within membrane vesicles (OMVs), derived from bacterial membrane. We...
Kingella kingae is a member of the commensal oropharyngeal flora young children. Improvements in detection methods have led to recognition K. as an emerging pathogen that frequently causes osteoarticular infections children and severe form infective endocarditis adults. secretes membrane-damaging RTX (Repeat ToXin) toxin, RtxA, which implicated development clinical infections. However, mechanism by RtxA recognizes kills host cells largely unexplored. To facilitate structure-function studies...
The leukotoxin (LtxA) produced by Aggregatibacter actinomycetemcomitans kills host immune cells, allowing the bacterium to establish an ecological niche in upper aerodigestive tract of its human host. interaction LtxA with cells is both complex and multifaceted, involving membrane lipids as well cell-surface proteins. In initial encounter cell, associates lymphocyte function-associated antigen-1, a cell surface adhesion glycoprotein. However, we have also demonstrated that toxin strongly...
Recognition of and binding to cholesterol on the host cell membrane is an initial step in mechanism numerous pathogens, including viruses, bacteria, bacterial toxins; however, a viable method inhibiting this interaction has not yet been uncovered. Here, we describe by which recognition amino acid consensus peptide interacts with inhibits activity cholesterol-binding leukotoxin (LtxA). Using series biophysical techniques, have shown that recognizes hydroxyl group nanomolar affinity does...
Our investigation is motivated by the need to design bilayer membranes with tunable interfacial and mechanical properties for use in a range of applications, such as targeted drug delivery, sensing imaging. We draw inspiration from biological cell focus on their principal constituents. In this paper, we present our results role molecular architecture interfacial, structural dynamical bio-inspired membranes. four lipid architectures variations head group shape hydrocarbon tail length. Each...
Our investigation is motivated by the need to design bilayer membranes with tunable interfacial and mechanical properties for use in a range of applications, such as targeted drug delivery, sensing imaging. We draw inspiration from biological cell focus on their principal constituents. In this paper, we present our results role molecular architecture interfacial, structural dynamical bio-inspired membranes. four lipid architectures variations head group shape hydrocarbon tail length. Each...