A5074992316- Global Maternal and Child Health
- HIV/AIDS Impact and Responses
- Fungal and yeast genetics research
- Healthcare Systems and Reforms
- Child Nutrition and Water Access
- Education and Technology Integration
- Microbial Metabolic Engineering and Bioproduction
- Genomics and Phylogenetic Studies
- Healthcare Policy and Management
- Global Health Care Issues
- RNA and protein synthesis mechanisms
- CRISPR and Genetic Engineering
- Fermentation and Sensory Analysis
- Photosynthetic Processes and Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
- Fungal Infections and Studies
- Injury Epidemiology and Prevention
- Biofuel production and bioconversion
- Yeasts and Rust Fungi Studies
- Traffic and Road Safety
- Poverty, Education, and Child Welfare
- Breastfeeding Practices and Influences
- Early Childhood Education and Development
- Antifungal resistance and susceptibility
- School Choice and Performance
University College London
2012-2025
Worcester Polytechnic Institute
2018-2024
Michigan State University
2018
King's College Hospital
2012
Freeman Hospital
2012
Edinburgh Royal Infirmary
2012
Wishaw General Hospital
2012
Introduction The COVID-19 pandemic and the restriction policies implemented by Government of Malawi may have disrupted routine health service utilisation. We aimed to find evidence for such disruptions quantify any changes type level care. Methods extracted nationwide usage data 2015–2021 from electronic information management systems in Malawi. Two datasets were prepared: unadjusted adjusted; latter, unreported monthly entries a facility filled through systematic rules based on reported...
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Malawi is vulnerable to climate-related shocks, which are projected worsen. Whilst some dimensions of this vulnerability have been characterised, little known about healthcare sector resilience. Coupling facility-specific data on antenatal care (ANC) service provision in with gridded precipitation data, we use regression analyses characterise the historic relationship between and access. We estimate that, 2012 2024, negatively impacted ANC utilisation Malawi, up 1 20 appointments disrupted...
Abstract Maternal and perinatal morbidity mortality remain high in Malawi, partially due to gaps the coverage quality of health services. We developed an individual-based model maternal healthcare situated a ‘whole-health system, all-disease’ framework ( Thanzi La Onse ). modelled sixteen scenarios estimating impact current improved antenatal, intrapartum, postnatal services from 2023 2030. Whilst service delivery is inferred avert mortality, largest reductions stillbirth, neonatal rates...
Global health initiatives have expanded access to treatment for infectious diseases - especially HIV, tuberculosis, and malaria (HTM) in low- middle-income countries. However, these "vertically"-funded programs often operate within fragile systems, where workforce shortages supply chain failures constrain their effectiveness sustainability. Meanwhile, evaluating the impact value-for-money of "horizontal" investments such as strengthening or boosting healthcare workforce, synergies with...
To undertake an descriptive analysis of the health needs, healthcare practices and barriers to accessing faced by women in Lower Napo River Region, Peru, understand literacy regarding cervical cancer need for more effective screening services.We performed a community-based needs assessment adapting Demographic Health survey methodology with additional questions determining female on assessing availability services. We surveyed (N = 121) across all households six communities along River,...
<title>Abstract</title> <bold>Background: </bold>To make the best use of health resources, it is crucial to understand healthcare needs a population – including how will evolve and respond changing epidemiological context patient behaviour this compares capabilities deliver with existing workforce. Existing approaches planning either rely on using observed demand from fixed historical period or models estimate within narrow domain (e.g., specific diease area programme). A new data-grounded...
In all health-care systems, decisions need to be made regarding allocation of available resources. Evidence is needed for these decisions, especially in low-income countries. We aimed estimate how resources provided by the public sector were used Malawi during 2015-19 and effects strengthening services.
Introduction In 2016, the WHO published recommendations increasing number of recommended antenatal care (ANC) visits per pregnancy from four to eight. Prior implementation this policy, coverage ANC has been suboptimal in many low-income settings. study we explore socio-demographic factors associated with early initiation first contact and attending at least (“ANC4+”) Malawi using Demographic Health Survey (MDHS) data collected between 2004 prior new recommendations. Methods We combined...
Abstract Yeast whole genome sequencing (WGS) lacks end-to-end workflows that identify genetic engineering. Here we present Prymetime, a tool assembles yeast plasmids and chromosomes annotates engineering sequences. It is hybrid workflow—it uses short long reads as inputs to perform separate linear circular assembly steps. This structure necessary accurately resolve sequences in the genome. We show this by assembling diverse engineered yeasts, some cases revealing unintended deletions...
Abstract Despite improvements in maternal and perinatal health Malawi, morbidity mortality remain high, partially due to gaps the coverage quality of services. We developed an individual-based simulation model healthcare situated a ‘whole-health system, all-disease’ framework. considered scenarios estimate impact current coverage, improved antenatal, intrapartum, postnatal services from 2023 2030. Whilst service delivery is inferred avert mortality, there scope substantially improve...
Synthetic biology is creating genetically engineered organisms at an increasing rate for many potentially valuable applications, but this potential comes with the risk of misuse or accidental release. To begin to address issue, we have developed a system called GUARDIAN that can automatically detect signatures engineering in DNA sequencing data, and conducted blinded test using curated Test Evaluation (T&E) data set. uses ensemble approach based on guiding principle no single likely be able...
Abstract Background Road traffic injuries are a significant cause of death and disability globally. However, in some countries the exact health burden caused by road is unknown. In Malawi, there no central reporting mechanism for so extent hard to determine. A limited number models predict incidence mortality due injury Malawi. These estimates vary greatly, owing differences assumptions, on population remains unclear. Methods We use an individual-based model combine epidemiological with...
Despite high vaccination rates, the incidence of whooping cough has steadily been increasing in developing countries for several decades. The current acellular pertussis (aP) vaccines all include major protective antigen toxin (PTx) and are safer, but they appear to be less than infection or older, whole-cell vaccines. To better understand attributes individual antibodies stimulated by aP, we isolated plasmablast clones recognizing PTx after booster immunization two donors. Five unique...
Background: Consumable stock-outs negatively affect health outcomes not only by impeding or delaying the effective delivery of services but also discouraging patients from seeking care. Consequently, supply chain strengthening is being adopted as a key component national strategies. However, evidence on factors associated with limited.Methods: In this study, we use facility census data Malawi to identify consumables stock-outs. We estimate multilevel logistic regression model binary outcome...
Malawi is steadily advancing towards the UNAIDS and WHO End TB programme targets, with joint goals of eliminating AIDS as public health threats. Here we examine projected impact reaching these targets potential mitigating effects consumables constraints.Methods: The Thanzi la Onse model an individual-based multi-disease simulation which represents HIV together, alongside other diseases, gates access to essential medicines according empirical estimates availability. integrates dynamic disease...
Abstract Malawi has high unmet need for contraception with a costed national plan to increase use. Estimating how such investments might impact future population size in can help policymakers understand effects and value of policies uptake. We developed new model pregnancy using individual‐level data capturing complexities initiation, switching, discontinuation, failure by method, accounting differences individual characteristics. modeled scale‐up via campaign initiation (Pop) postpartum...
Abstract Background Decisions need to be made in all healthcare systems about the allocation of available resources with aim improving population health. Evidence is needed for these decisions, which can have enormous consequences health, especially lower-income settings. Methods We address this using an individual-based simulation model and service delivery that we developed Malawi, drawing on demographic, epidemiological routine system data (on facilities, staff, consumables). compare...
is an opportunistic fungal pathogen with high mortality rates which presents a clear threat to public health. The risk of