A5060638295- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Evolutionary Psychology and Human Behavior
- Genetics and Neurodevelopmental Disorders
- Neuroscience of respiration and sleep
- Circadian rhythm and melatonin
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Neurotoxicity Research
- Lipid Membrane Structure and Behavior
- Phosphodiesterase function and regulation
- Infant Health and Development
- Mitochondrial Function and Pathology
Northwestern University
2009-2017
Translational Genomics Research Institute
2017
Rosalind Franklin University of Medicine and Science
2009-2011
Franklin University
2009-2011
Over time, memory retrieval is thought to transfer from the hippocampus a distributed network of neocortical sites. Of these sites, retrosplenial cortex (RSC) robustly activated during remotely acquired, emotionally valenced memories. It unclear, however, whether RSC specifically involved in storage or retrieval, and which neurotransmitter receptor mechanisms serve its function. We addressed questions by inhibiting NMDARs via infusions APV before tests for context fear mice. Anterior...
Learning processes mediating conditioning and extinction of contextual fear require activation several key signaling pathways in the hippocampus. Principal hippocampal CA1 neurons respond to by a coordinated multiple protein kinases immediate early genes, such as cFos , enabling rapid lasting consolidation memory. The extracellular signal-regulated kinase (Erk) additionally acts central mediator extinction. It is not known however, whether these molecular events take place overlapping or...
Abstract Activation of NMDA receptors (NMDAR) in the hippocampus is essential for formation contextual and trace memory. However, role individual NMDAR subunits molecular mechanisms contributing to these memory processes not known. Here we demonstrate, using intrahippocampal injection subunit‐selective compounds, that NR2A‐preferring antagonist impaired fear conditioning as well learning‐induced increase nuclear protein c‐Fos. The NR2B‐specific antagonist, on other hand, selectively blocked...
General or brain-region-specific decreases in spine number morphology accompany major neuropsychiatric disorders. It is unclear, however, whether changes density are specific for an individual mental process disorder and, if so, which molecules confer such specificity. Here we identify the scaffolding protein IQGAP1 as a key regulator of dendritic with role cognitive but not emotional motivational processes. We show that important component NMDAR multiprotein complexes and functionally...
<h3>Objective:</h3> To identify inherited or de novo mutations associated with a suite of neurodevelopmental abnormalities in 10-year-old patient displaying ataxia, motor and speech delay, intellectual disability. <h3>Methods:</h3> We performed whole-exome sequencing the proband her parents. A pathogenic gene variant was identified as damaging based on sequence conservation, function, association disorders having similar phenotypic profiles. Functional characterization mutated protein vitro...
Extinction of fear requires learning that anticipated aversive events no longer occur. Animal models reveal sustained phosphorylation the extracellular signal-regulated kinase (Erk) in hippocampal CA1 neurons plays an important role this process. However, key signals triggering and regulating activity Erk are not known. By varying degree expected delivered reinforcement, we demonstrate specifically responds to prediction errors contextual events. An increase somatonuclear phospho-Erk (pErk)...
Ionotropic glutamate receptor (iGluR) subunits are N-glycosylated at 4-12 sites, and Golgi processing produces mature receptors that contain high-mannose, hybrid complex oligosaccharides. N-glycosylation is crucial for biogenesis, influences trafficking provides a binding site carbohydrate proteins. Glycan moieties large, polar occasionally charged, they attached sites along iGluRs position them involvement in the structural changes underlying gating. Altering glycan content on kainate...