A5010682044- Immunodeficiency and Autoimmune Disorders
- Antifungal resistance and susceptibility
- Neonatal and Maternal Infections
- Streptococcal Infections and Treatments
- Fungal Infections and Studies
- Systemic Lupus Erythematosus Research
- Mycobacterium research and diagnosis
- Herbal Medicine Research Studies
- Ocular Diseases and Behçet’s Syndrome
- T-cell and B-cell Immunology
- Hepatitis C virus research
- Whipple's Disease and Interleukins
- Retinal and Optic Conditions
- Antimicrobial Peptides and Activities
- Immune Cell Function and Interaction
- Carcinogens and Genotoxicity Assessment
- Diabetes Management and Research
- Histone Deacetylase Inhibitors Research
- Spondyloarthritis Studies and Treatments
- Chronic Lymphocytic Leukemia Research
- Pregnancy and Medication Impact
- Psoriasis: Treatment and Pathogenesis
- Reproductive tract infections research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Hepatitis Viruses Studies and Epidemiology
Novartis (Germany)
2020-2023
Radboud University Nijmegen
2012-2020
Radboud University Medical Center
2012-2020
San Diego State University
2014-2015
IL-1 drives Th responses, particularly Th17, in host defense. Sharing the same co-receptor, family member IL-36 exhibits properties similar to those of IL-1. In present study, we investigated role Aspergillus fumigatus-induced human responses. We observed that different morphological forms A. fumigatus variably increase steady-state mRNA subfamily members. IL-36α is not significantly induced by any form Aspergillus. Most strikingly, IL-36γ live conidia and heat-killed hyphae, whereas IL-36Ra...
Group B streptococcus (GBS) can cause severe disease in susceptible hosts, including newborns, pregnant women, and the elderly. GBS serine-rich repeat (Srr) surface glycoproteins are important adhesins/invasins multiple host tissues, vagina. However, exact molecular mechanisms contributing to their importance colonization unknown. We have recently determined that Srr proteins contain a fibrinogen-binding region (BR) hypothesize Srr-mediated fibrinogen binding may contribute cervicovaginal...
Heterozygous STAT1 gain-of-function (GOF) mutations are associated with chronic mucocutaneous candidiasis and a broad spectrum of infectious, inflammatory, vascular manifestations. We describe therapeutic failures the Janus Kinase (JAK) inhibitor ruxolitinib in 2 GOF patients severe invasive or cutaneous fungal infections.
ABSTRACT Streptococcus agalactiae (group B streptococcus [GBS]) colonizes the rectovaginal tract in 20% to 30% of women and during pregnancy can be transmitted newborn, causing severe invasive disease. Current routine screening antibiotic prophylaxis have fallen short complete prevention GBS transmission, remains a leading cause neonatal infection. We investigated ability salivarius , predominant member native human oral microbiota, control colonization. Comparison antibacterial activities...
STAT1 mutations cause chronic mucocutaneous candidiasis (CMC), while STAT3 hyper-IgE syndrome (HIES). CMC and HIES patients have T helper (Th) 17 defects suffering from mucosal Candida infections, but only with show an allergic phenotype eczema, eosinophilia high IgE levels.We investigated whether differential Th2 Th9 responses may explain the clinical differences.Peripheral blood mononuclear cells of (n = 4), atopic dermatitis 4) healthy volunteers 13) were stimulated Staphylococcus aureus,...
Candidiasis, aspergillosis, and mucormycosis cause the majority of nosocomial fungal infections in immunocompromised patients. Using an unbiased transcriptional profiling PBMCs exposed to species causing these infections, we found a core host response healthy individuals that may govern effective clearance: it consists 156 transcripts, involving canonical non-canonical immune pathways. Systematic investigation key steps antifungal defense revealed fungal-specific signatures. As previously...
Signal transducer and activator of transcription 1 (STAT-1) gain-of-function (GOF) mutations cause chronic mucocutaneous candidiasis (CMC), a disease associated with Candida albicans Staphylococcus aureus infection. Patients suffer from dysegulated immune responses due to aberrant cell programming function. We investigated the effect inhibitory molecules targeting histone deacetylases (HDACi) on peripheral blood mononuclear cells (PBMCs) healthy controls patients CMC towards microbes...
Behçet's disease (BD) is an inflammatory mainly affecting men along the ancient Silk Route. In present study we describe a Dutch family suffering from BD-like with extreme pathergic responses, but without systemic inflammation. Genetic assessment revealed combination of human leukocyte antigen (HLA)-B*51 risk-allele together rare heterozygous variant in CSF2 gene (c.130A>C, p.N44H) encoding for granulocyte-macrophage colony-stimulating factor (GM-CSF) found by whole exome sequencing. We...
Background: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease which primarily affects the axial skeleton resulting in back pain and stiffness. According to guideline, first-line treatment includes non-steroidal anti-inflammatory drugs (NSAIDs), conventional synthetic disease-modifying antirheumatic (csDMARDs) non-pharmacological treatment. Second line involves biological (bDMARDs) such as tumour necrosis factor interleukin-17 inhibitors. Objectives: The aim of this social...