A5032612136- Nanoparticles: synthesis and applications
- Silk-based biomaterials and applications
- Drug-Induced Hepatotoxicity and Protection
- Natural Antidiabetic Agents Studies
- Antimicrobial Peptides and Activities
- Liver Disease Diagnosis and Treatment
- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
- Medicinal Plants and Neuroprotection
- Curcumin's Biomedical Applications
- Vitamin C and Antioxidants Research
- Iron Metabolism and Disorders
- Wound Healing and Treatments
- Heavy Metal Exposure and Toxicity
- Biochemical and Structural Characterization
- Advanced Nanomaterials in Catalysis
- Berberine and alkaloids research
- Hemoglobinopathies and Related Disorders
- Nanocomposite Films for Food Packaging
- Plant Toxicity and Pharmacological Properties
- Biocrusts and Microbial Ecology
- Pomegranate: compositions and health benefits
- Medical and Biological Ozone Research
- Ethnobotanical and Medicinal Plants Studies
- Drug Transport and Resistance Mechanisms
University of Azad Jammu and Kashmir
2019-2024
Women University of Azad Jammu & Kashmir Bagh
2024
Government College University, Lahore
2019-2023
Abstract Diabetes is a life‐threatening disease that affects different parts of the body including liver, kidney, and pancreas. The core root diabetes mainly linked to oxidative stress produced by reactive oxygen species (ROS). Berberis lyceum Royle (BLR) source natural products. It comprises numerous bioactive compounds having antioxidant activities. In current investigation, silver nanoparticles from BLR extract were synthesized, characterized, assessed for antidiabetic potential. UV...
Hepatocellular carcinoma is the most frequent primary malignancy of liver and accounts for as many one million deaths worldwide in a year.The aim present study was to evaluate anti-cancerous efficiency Bergenia ciliata rhizome against diethylnitrosoamine induced hepatocarcinogenesis Balb C mice.One percent prepared by using 99 ml normal saline NaCl (0.9 percent) solution which added 1 concentrated (DEN) (0.01 μg/μl). Extract maceration technique. Mice were classified into four groups...
Abstract Now a day’s multidrug resistance phenomenon has become the main cause for concern and there been an inadequate achievement in development of novel antibiotics to treat bacterial infections. Therefore, is unmet need search adjuvant. Vitamin C one such promising The present study was aimed elucidate antibacterial effect vitamin at various temperatures (4°C, 37°C 50°C) pH (3, 8, 11), against Gram-positive Gram-negative bacteria concentrations (5-20 mg/ml) through agar well diffusion...
Abstract Infectious diseases are becoming a worldwide threat due to antibiotic resistance. Therefore, it is necessary prepare innovative antibiotics against bactericidal activities. The development of nanomedicine has been greatly aided by nanotechnology. A focal point exploration involves the production noble metal nanoparticles, owing their diverse applications. study's subjects synthesis, characterization, and assessment silver nanoparticles (AgNPs) derived from Berberis lyceum Royle root...
Paclitaxel resistance is a challenging factor in chemotherapy resulting poor prognosis and cancer recurrence. Signal transducer activator of transcription 3 (STAT3), key factor, performs critical role development, cell survival chemoresistance, while its inactivation overwhelms drug numerous types including lung cancer. Additionally, the fucosyltransferase 4 (FUT4) crucial enzyme post-translational modification cell-surface proteins involved various pathological conditions such as tumor...
Elderly mortality as well morbidity have been affected by immune-senescence, or immune system ageing. Age-related quantitative and qualitative shifts affect innate adaptive responses, cells, soluble immune-mediated substances, lymphoid non-lymphoid distant tissue, etc. The thymus gland, which is an essential organ of the responsible to produce T lymphocytes, begins shrink after puberty continues do so a person ages. This process known thymic involution. As gland becomes smaller less active,...
The antibacterial activity of synthetic antimicrobial agents is well known, but most them have several side effects and are effective against selective microbes. Recently, major concern for the microbiologists to investigate some stable, non-toxic, cheap, eco-friendly with a wide range bactericidal potential. A cost-effective environmentally friendly alternate has been proposed in form green synthesized nanoparticles. Present study was designed fabricate sericin-coated silver nanoparticles...
Polycyclic aromatic hydrocarbons (PAHs) such as 7, 12-dimethylbenzneanthracene (DMBA), due to long-term bioaccumulation cause serious physiological processes and behavioral dysfunctions cancer, ageing, hypertension. Silk sericin (SS) is instrumental in cancer applications presence of flavonoids carotenoids which are natural pigments, present the layer that has antioxidant antityrosinase activity. It reduces oxidative stress suppresses cytokines while interacting with reactive oxygen species...
Antioxidants are materials that scavenge or remove free radicals from living systems. The oxidation process ends in the production of radicals. These chief birthplace cancerous cells. Antioxidizing agents radical intermediates by terminating processes being oxidized themselves. On other hand, infectious diseases affect world on a large scale. To fight these several synthetic compounds have been used. Plant based medications play important role this regard. So, current research aimed to...
Hexavalent chromium, toxic heavy metal, among the top-rated environmental contaminants, is declared a potent endocrine disruptor in humans and animals. The present study was planned to find harmful effects on reproductive system caused by Cr (VI) ameliorative effect of Nigella sativa sativa-mediated AgNP male mice (Mus musculus). In study, known infertility medicine, clomiphene citrate also used as positive control. main objective assess potential oral administration dose 50 mg/kg BW...
The main purpose was to elucidate the potential anti-aging impact of sericin, due its anti-oxidant in D-galactose induced mice model. To induce natural aging mice, a solution 0.9 % saline containing (250 mg/kg b.w.) injected intraperitoneally for period 60 days. In this experiment, 56 male were arbitrarily categorized into 8 groups (1: control; 2: D-Galactose b.w), Group 3: Sericin (150 4: Metformin mg/kg), 5: sericin (P), 6; (T), 7; Met 8; (T). level Glutathione reductase (2.1 ± 0.2...
The main objective of current study was to investigate the chemopreventive and chemotherapeutic activity Artemisia vulgaris extract on diethylnitrosoamine induced hepatocarcinogenesis in Balb C mice. Diethylnitrosoamine (DEN: 0.9%) prepared induce hepatocarcinoma (AV) by maceration technique. Mice were classified into four groups as follows: Group 1 a control group (N=7) received saline solution (3.5 μl/mg), 2 (N=14) μl/mg) intraperitoneally once week for eight consecutive weeks, 3 only...
Diabetes is a life-threatening disease, and chronic diabetes affects parts of the body including liver, kidney, pancreas. The root cause mainly associated with oxidative stress produced by reactive oxygen species. Minocycline drug multi-substituted phenol ring has shown excellent antioxidant activities. objective present study was to investigate antidiabetic potential minocycline-modified silver nanoparticles (mino/AgNPs) against alloxan-induced diabetic mice. mino/AgNPs were synthesized...
Liver diseases pose a significant global health burden, with limited therapeutic options for chronic cases. Zinc oxide (ZnO) nanomaterials have emerged as promising candidates hepatoprotection due to their antioxidant, anti-inflammatory, and regenerative properties. However, potential remains hampered by insufficient drug loading controlled release. The current study explores the intercalation of Naproxen (Nx), potent anti-inflammatory analgesic drug, within ZnO stacked nanosheets (SNSs)...
Abstract Diabetes is involved in delayed wound healing that can be cured by natural products such as garlic, turmeric, and fibroin extracts. Alloxan monohydrate used for inducing diabetes mice. The percent contraction of garlic (150 mg/ml), turmeric (100 (50 individually combinations mg/ml) + was checked evaluating the time, % histological analysis. serum level MMPs (MMP 2, MMP7, MMP 9), pro-inflammatory cytokines (TNF-α, IL-6, IL-8), TIMPs were evaluated. With combination three extracts...
Background: Present research was planned to examine the shielding effect of Daucus carota root extract pre-treatment on carbon tetrachloride-induced hepatotoxicity in Balb C mice.
 Objective: To cover assessment enzymatic activity such as Aspartate aminotransferase (AST), alanine (ALT) and lactate dehydrogenase (LDH) biochemical constituents like cholesterol, protein, lipids, glucose urea contents both blood liver while RNA DNA substances exclusively liver.
 Setting: The induction...
Abstract Bacitracin is one of the most important antibiotics used in different biomedical fields. It helps to achieve sizeable amount foreign exchange due its use poultry feed. The cheap agricultural wastes are readily available for preparation fermentation media bacitracin production. microorganisms could be mutated with chemicals and UV radiation improve Thus, current study was focused on synthesis low‐cost effective by mutant strains Bacillus licheniformis , employing submerged technique....