Cisplatin is a chemotherapeutic agent widely used in treatment of several cancers. It documented as major cause clinical nephrotoxicity and hepatotoxicity. The purpose this study was to investigate the involvement oxidative stress pathogenesis cisplatin-induced liver kidney injury. Wistar rats were divided into four groups. Group 1 (control) intraperitoneally (IP) injected with single dose 0.85% normal saline. Groups 2, 3 4 IP doses cisplatin at 10, 25 50 mg/kg body weight (BW),...

cis-Diammineplatinum (II) dichloride (cisplatin) is the important anti-cancer agent useful in treatment of various cancers. Unfortunately, it can produce unwanted side effects tissues, including liver. The present study investigated possible protective role curcumin and α-tocopherol against oxidative stress-induced hepatotoxicity rats upon cisplatin treatment. Male Wistar were divided into five groups (n = 5). Saline Cis groups, intraperitoneal (i.p.) injected with normal saline [20 mg/kg...

Liver involvement in severe Plasmodium falciparum infection is commonly a significant cause of morbidity and mortality among humans. The clinical presentation jaundice often reflects certain degree liver damage. This study investigated the pathology P. malaria as well regulation occurrence apoptosis cellular components formalin-fixed, paraffin-embedded tissues. tissues used came from patients who died with hyperbilirubinaemia (total bilirubin (TB) ≥ 51.3 μmol/L or 3 mg/dl) (12 cases),...

Soil-transmitted helminth (STH) infections are major public health problems in poor and developing countries that require fecal contamination of the environment for transmission. The consumption raw vegetables without proper washing is one main routes intestinal parasite acquisition. Therefore, this study was designed to detect prevalence parasitic commonly consumed sold three central open-air markets Nakhon Si Thammarat province, southern Thailand. A total 265 fresh vegetable samples...

Frailty is an important condition in elderly individuals because it increases disability, morbidity, and mortality. The definition frailty from the Cardiovascular Health Study (CHS) criteria used worldwide defined as fulfilling 3 out of 5 phenotypic that indicate compromised energetics: weakness, slowness, low level physical activity, self-reported exhaustion, unintentional weight loss.This research aims to study validity screening methods, e.g., Clinical Scale, simple FRAIL questionnaire,...

Drug resistance exists in almost all antimalarial drugs currently use, leading to an urgent need identify new drugs. Medicinal plant use is alternative approach chemotherapy. This study aimed explore potent medicinal plants from Prabchompoothaweep remedy for drug development.Forty-eight crude extracts and its 23 ingredients were investigated vitro properties using Plasmodium lactate dehydrogenase (pLDH) enzyme against falciparum K1 strain toxicity effects evaluated Vero cells. The with...

Intestinal parasitic infections remain prevalent and constitute a public health problem in certain rural areas of Thailand. Village volunteers (VHVs), who are members Thai healthcare alliance, function as key providers prevention measures, disease control, education share national promotion campaigns with community members. This study is aimed at evaluating the prevalence, intensity, risk factors for intestinal infection VHVs order to design awareness target population.This cross-sectional...

Abstract Background Cerebral malaria (CM) caused by Plasmodium falciparum is known to be associated with the sequestration of parasitized red blood cells (PRBCs) in microvasculature and release soluble cytokines. In addition, involvement signaling molecules has gained wide interest pathogenesis CM. An important factor, nuclear factor kappa B (NF-κB) regulate apoptosis. This work aimed study expression NF-κB p65 its correlation apoptosis brain fatal Methods The cleaved caspase-3 P. cases was...

BackgroundThe purpose of this study was to use the body painting method teach hand anatomy a group preclinical medical students.MethodsStudents reviewed using traditional and exercise. Feedback retention anatomy-related information were examined by questionnaire multiple-choice questions, respectively, immediately 1 month after exercise.ResultsStudents agreed that exercise advantageous helped facilitate self-active learning in-class lessons. While there no significant difference in knowledge...

At present, the emergence and spread of antimalarial drug resistance has become a significant problem worldwide. There been challenge in searching for natural products development novel drugs. Therefore, this study aims to evaluate compounds from Dioscorea bulbifera responsible properties investigate potential interactions with Plasmodium falciparum lactate dehydrogenase (PfLDH), an essential glycolytic enzyme parasite's life cycle.An vitro activity against chloroquine (CQ)-resistant (K1...

Background. The world population has exhibited increased trust in folk medicine, including Thai for the treatment of various illnesses. However, comparative antioxidant and cytoprotective activities against oxidative damage Tri-Than-Thip (Tri-TT), a remedy, have not been reported. Objectives. purpose this study was to evaluate capacities Tri-TT its herbal constituents, Cassia fistula, Pithecellobium dulce, Ficus benjamina. Methods. Extracts were obtained from constituents. free radical...

Soil-transmitted helminth (STH) infections are among the most common type of worldwide and widely distributed in tropical areas. In rural areas southern Thailand where land is used for agriculture, children at risk acquiring parasites, especially STHs. Assessing current situation regarding parasitic infection these a prerequisite developing appropriate control measures. This study aimed determining prevalence intestinal infections, intensity STH associated factors primary schoolchildren...

Abstract Background Soil-transmitted helminth (STH) infection is a neglected tropical disease affecting approximately 1.5 billion people worldwide. In past decades, most studies focused on STH in preschool-aged and school-aged children different regions of Thailand. However, little known about the prevalence intensity elderly population. Therefore, aim this study was to determine current infections identify associated risk factors among Methods A cross-sectional conducted from July November...

Increased visceral fat is associated with an increased mortality rate. Bioelectrical impedance analysis (BIA) a noninvasive method to assess that easily accessible and avoids exposure radiation. It unknown how rating from machine correlates the serum lipid profile fasting blood sugar (FBS). The aim of this research study correlation obtained by FBS. This cross-sectional involved 90 obese adults, ranging in age 18 60 years old. was measured BIA. results demonstrated significant positive...

Overweight/obesity is a pressing international health concern, and conventional treatments demonstrate poor long-term efficacy. Several studies have shown that yoga can control risk factors for cardiovascular disease, obesity, psychosocial stress. The present study aimed to assess the effect of continuous (asanas, pranayama, Surya Namaskar yoga) on body composition in overweight participants. Forty adolescents with obesity were enrolled this study. was conceived as prospective,...

The increasing resistance of parasites to antimalarial drugs and the limited number effective are greatest challenges in treatment malaria. It is necessary search for an alternative medicine use as a new, more drug. Therefore, this study aimed evaluate

Ya That Somdun (YTS) is a traditional Thai medicine composed of six herbs used as strengthening tonic. Some the constituting YTS have antihyperlipidemic and anti-obesity activities. The objective this study was to elucidate properties extract in rats with cholesterol suspension-induced hyperlipidemia. Male Sprague-Dawley were subdivided into four groups: normal control (NC), hyperlipidemic (HC), those who administered 100 (YTS100) 200 mg (YTS200) YTS/kg body weight (BW). Hyperlipidemic...

Background/Objectives: Sepsis-induced cardiac dysfunction is a major problem that often leads to severe complications and poor prognosis. Despite the growing awareness of its impact, effective treatment options for sepsis-induced remain limited. To date, fermented products Houttuynia cordata (HC), known rich bioactive properties, have shown potential in modulating inflammatory oxidative stress pathways. However, with HC juice (FHJ) lipopolysaccharide (LPS)-induced sepsis rats has not been...

Actinobacteria are widely recognized as prolific producers of bioactive metabolites with diverse biological properties, yet they remain largely unexplored. In this study, we investigated the antimicrobial potential and chemical diversity crude extracts from actinobacterial strains isolated mangrove sediments collected in Chonburi Chachoengsao provinces Thailand. Taxonomic identification confirmed that these isolates belong to genus Streptomyces. Notably, ten isolates, identified Streptomyces...

Parasitic infections remain a significant public health issue in Thailand. Exposure to intestinal parasites occurs through consumption of improperly washed raw vegetables and handling contaminated soil without proper hygiene. This study assessed the prevalence school soil, along with associated factors, Koh Yao, Phang Nga Province, Vegetables (21 types) were collected from local markets stores Yao Noi, Yai, Phru Nai. Moreover, samples playgrounds, football fields, sidewalks, schoolyards,...

The process of cytoadhesion in Plasmodium falciparum malaria infection causes signaling processes that lead to structural and functional changes at the cellular level. Histopathological acute kidney injury (AKI) P. often involve glomerular proliferation, thickening basement membrane, tubular necrosis, interstitial inflammation. Focusing on glomeruli, this study aimed investigate tight junction-associated protein- zonula occludens-1 (ZO-1) patients. Kidney tissues were grouped into with AKI...

Abstract Background Human toxocariasis is a parasitic zoonosis caused by parasite in the genus Toxocara and transmitted mainly accidental ingestion of embryonated canis (dog roundworm) or T. cati (cat eggs. Several studies reported that children were main population at risk for infection. Currently, no reports on seroprevalence infection Thailand are available, its status remains unknown among who live rural areas southern Thailand. Objective This study aimed to investigate associated...

Phy-Blica-D is a traditional Thai polyherbal formula that has reduced oxidative stress in non-communicable diseases. However, evidence supporting the gastroprotective effects of not been previously reported. Therefore, this study aimed to evaluate against gastric ulcers rats and investigate potential underlying mechanism. To estimate possible mechanisms action, we examined levels markers, such as reactive oxygen species (ROS) malondialdehyde (MDA), well antioxidant enzymes, including...

Introduction: Garcinia atroviridis has been used for traditional medicines, healthy foods and tea. The chemical compositions biological activities of fruit, stem bark root have widely studied. However, the phytochemical components in leaves (GAL) are limited. This research aims to study stress resistance effects GAL Caenorhabditis elegans ( C. ). Methods: To investigate antioxidant extract, ethanol extract was characterized by liquid chromatography-quadrupole time-of-flight mass spectrometry...