Spices and herbs have been used in food since ancient times to give taste flavor also as preservatives disease remedies. In Cameroon, the use of spices other aromatic plants flavoring is an integral part dietary behavior, but relatively little known about their antifungal potential. The present work was designed assess properties extracts from Cameroonian dietary. vitro activities twenty three one were assessed by broth micro-dilution method against eight fungi. Also, vivo activity Olax...

Context: Peptic ulcer is one of the most common diseases affecting mankind. Although there are many products used for its treatment, these produce severe adverse reactions requiring search novel compounds. Some Afromomum species traditionally to cure acute gastritis.Objective: To evaluate antiulcer activity methanol extract Aframomum pruinosum Gagnepain (Zingiberaceae) seeds against two major etiologic agents peptic disease; Helicobacter pylori and non-steroidal anti-inflammatory...

Medicinal plants are known as sources of potential antibacterial compounds including alkaloids. The aim the present study was to evaluate activities extract, fractions, and some secondary metabolites isolated from leaves Crinum glaucum A. Chev. (Amaryllidaceae). were performed with ethanol (EtOH) well ethyl acetate (EtOAc) n-butanol (n-BuOH) fractions. Repeated column chromatography fractions led isolation several their structures elucidated mainly by means extensive spectroscopic analysis...

Eriobotrya japonica (loquat) has been used in African traditional medicine with numerous beneficial health effects. The extracts from loquat contain several bioactive compounds a plethora of pharmacological properties. However, scientific study on the activity against aetiological agent cryptococcosis not yet reported. Therefore, this aimed to investigate antifungal potential various clinical isolates Cryptococcus neoformans. Quantitative and qualitative phytochemical analyses were made by...

Invasive fungal infections are important causes of mortality despite advances in antifungal therapy. The aim this study was collect information on plants used by traditional healers for the treatment Baham subdivision (Western region Cameroon) and to assess vitro antioxidant potentials extracts from medicinal surveyed. activity assessed broth micro-dilution method determined using free-radical scavenging assays. Kotschya strigosa Eryngium foetidum had potent with minimum inhibitory...

A new ceramide is being reported herein together with six known compounds from the methanol extract of leaves Lannea schimperi (Hochst. ex A.Rich.) Engl. The metabolites were obtained through repeated open column chromatography and characterized by spectroscopic spectrometric techniques. radical-scavenging activity crude isolated was evaluated using DPPH radical. results suggest studied species as prominent candidate to fight reactive oxygen (ROS).

BACKGROUND: Cryptococcus neoformans is responsible of cryptococcosis, a life-threatening infection that affects healthy and immunocompromised individuals. It the first cause adult acute meningitis in some sub-Saharan African countries with mortality rate about 100% cases inappropriate therapy. This study aimed at examining occurrence antifungal patterns isolates from pigeon droppings bat guanos west region Cameroon.METHODS: A total 350 samples were randomly collected three selected...

A previously unreported gallocatechin glycoside, (2 R,3S) 4'-O-methyl-gallocatechin-3-O-α-ʟ-rhamnopyranoside (1) and an unseparable mixture of two undescribed dihydromyricetin glycosides, R,3R) 4'-O-methyl-dihydromyricetin-3-O-α-ʟ-rhamnopyranoside (2a) b) along with three known compounds were isolated from the n-butanol soluble fraction stem bark Olax subscorpioidea Oliv. Their structures elucidated by detailed spectroscopic analyses, including 1H NMR, 13C 1H-1H COSY, HSQC, HMBC, NOESY,...

The phytochemical investigation of the MeOH extract from fruits Kotschya strigosa using repeated normal and reversed‐phase column chromatography Sephadex LH‐20 led to isolation characterization a new isoflavanol, named kotstrigoisoflavanol ( 1 ), together with three known compounds, diosmetin 2 β ‐sitosterol 3 3‐ O ‐ ‐d‐glucopyranoside β‐ sitosterol 4 ). antioxidant activity crude extract, 1, was determined 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH˙) method. IC 50 61.7 ± 0.2 μg/ml) 70.2 0.1 showed...

Phytochemical investigation of the seeds Pentaclethra macrophylla led to isolation a mixture two new aromatic monoterpene glycosides, pentamacrophylloside A (1a) and B (1b), together with six known secondary metabolites: Comososide (2), secopentaclethroside (3), caffeoylputrescine (4), β-sitosterol-3-O-β-D-glucopyranoside (5), 2-hydroxymethyl-5-(2-hydroxypropan-2-yl)phenol (6), sucrose (7). Their structures were elucidated mainly by extensive spectroscopic analysis (1D 2D NMR),...

The use of plants in the treatment various diseases is a practice known since ancient times, and even nowadays, number plant products are traditionally used as medicines. Many modern medicines frequently based on biologically active compounds. aim this study was to evaluate antimicrobial activity extract, fractions compounds isolated from Helichrysum odoratissimun (Asteraceae) against some bacteria fungi using broth microdilution method. vitro antibacterial antifungal activities EtOH...

Abstract A new saponin, 3- O -β- d -3-oxo-glucopyranosyl-ursa-12,20(30)-diene-27,28-dioic acid ( 1 ), was isolated from the methanol extract of stem bark Crossopteryx febrifuga together with known 3β- -glucopyranosyl-ursa-12,20(30)-diene-27,28-dioic 2 shanzhiside methyl ester 3 4 β-sitosterol 5 β-sitosterol-3- -glucopyranoside 6 ursa-12,20(30)-diene-27,28-dioic 7 hederagenin 8 and oleanolic 9 ). The structures were established by comprehensive interpretation their spectral data 1D- H 13 C),...

Three alkaloids including a new one, N-formyldihydrochelerythrine (1), together with four other known compounds were isolated from the stem bark of Caloncoba glauca. The structure compound was elucidated spectroscopic and mass spectrometric evidence. This is first report genus Caloncoba. Sesamin (4) [MIC = 256 μg/mL ( Candida albicans) dihydrochelerythrine (2) 32 C. albicans parapsilosis), 128 krusei)] had moderate to weak antifungal activity.

Phytochemical investigation of the methanol extracts from leaves and bark Senna siamea resulted in isolation one new flavone C-glycoside: apigenin-8-C-[6''-(E)-feruloyl]-β-D-glucopyranoside] (1), together with sixteen known compounds including quercetin-3-O-α-L-rhamnoside (2), vitexin (3), isovitexin (4), quercetin-3-O-β-D-glucopyranoside (5), quercetin-3-O-β-D-arabinopyranoside (6), quercetin (7), kaempferol (8), methyl inositol (9), sucrose (10), betulinic acid (11), vanillic (12),...

A new caffeate derivative from the ethanol extract of stem bark Cassia sieberiana DC. is described herein along with known secondary metabolites spectaline (2), iso-6-cassine (3), 3-O-methyl-chiro-inositol (4), monobehenin (5), octyl nonadecyloate (6), β-sitosterol (7), stigmasterol (8) and sitosterol 3-O-β-D-glucopyranoside (9). The chemical structures were elucidated by means various spectroscopic spectrometric techniques. Extract isolated compounds devoid inhibitory action against...

This study aimed to synthesize the silver nanoparticles (SNPs) and loaded chitosan (LCNPs) using Euphorbia prostata based on their anticandidal activity. Antioxidant capacity total phenolic flavonoid content of plant samples synthesized (NPs) were also evaluated. SNPs LCNPs prepared, respectively chemical reduction salt solution ionotropic gelation method. The activity was assessed by broth micro-dilution method antioxidant determined free-radical scavenging assays. NPs after optimization...

A new 3-arylcoumarin, 7-hydroxy-6-(1,1-dimethylallyl)-2′,5′-dihydroxy-4′-(3,3dimethylprenyl)-3-arylcoumarin (desmoarylcoumarin) 1, a previously unreported oleanane-type triterpenoid, 3β,22β,23-trihydroxyolean-12-en (episoyasapogenol B) 2, together with five known flavonoids including darbergioidin (3), isoferreirin (4), quercetin (5), vitexin (6), swertizin (7), and one carbohydrate, sucrose (8) were isolated from the methanolic extract of roots Desmodium salicifolium. Their structures...