A5051721674- Advanced Breast Cancer Therapies
- Lung Cancer Research Studies
- HER2/EGFR in Cancer Research
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Mobile Health and mHealth Applications
- Antifungal resistance and susceptibility
- Sarcoma Diagnosis and Treatment
- Fungal Infections and Studies
- Palliative Care and End-of-Life Issues
- Chronic Lymphocytic Leukemia Research
- Cancer-related Molecular Pathways
- Child Abuse and Trauma
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Gastroesophageal reflux and treatments
- Infectious Diseases and Mycology
- Renal Transplantation Outcomes and Treatments
- Innovative Human-Technology Interaction
- Bariatric Surgery and Outcomes
- Diabetes Treatment and Management
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Imaging and Diagnostics
- Organ Transplantation Techniques and Outcomes
- Pancreatic function and diabetes
- Plant-derived Lignans Synthesis and Bioactivity
Iowa State University
2022-2024
Pfizer (South Korea)
2021-2023
Catholic University of Korea
2012-2016
Seoul St. Mary's Hospital
2015-2016
St. Vincent's Hospital
2015
Pontifícia Universidade Católica de São Paulo
2014
Abstract Background Cyclin-dependent kinase 4/6 inhibitor (CDK4/6) therapy plus endocrine (ET) is an effective treatment for patients with hormone receptor-positive/human epidermal receptor 2-negative metastatic breast cancer (HR+/HER2− MBC); however, resistance common and poorly understood. A comprehensive genomic transcriptomic analysis of pretreatment post-treatment tumors from receiving palbociclib ET was performed to delineate molecular mechanisms drug resistance. Methods Tissue...
Metformin (MET) is a first-line drug for type 2 diabetes mellitus (DM); its effect on new-onset after transplantation caused by immunosuppressant therapy unclear. We compared the effects of MET DM tacrolimus (TAC) or sirolimus (SRL).DM was induced injection TAC (1.5 mg/kg) SRL (0.3 weeks in rats, and (200 injected more weeks. The were evaluated using an intraperitoneal glucose tolerance test (IPGTT) measuring plasma insulin concentration, islet size, glucose-stimulated secretion (GSIS)....
The use of calcineurin inhibitors is a well-known risk factor for hyperuricemia in kidney transplant recipients. We evaluated the effect febuxostat (Fx), new uric acid-lowering drug, on and renal injury an experimental model chronic tacrolimus (Tac)-induced nephropathy.Chronic Tac nephropathy was induced by administering (1.5 mg/kg/day) to rats low-salt diet (0.05%) with oxonic acid (OA, 2%, 0.2 g/kg/day) 28 days. Two doses Fx (5 10 mg/kg) were concomitantly administered or vehicle (Vh)....
Background Arterial stiffness is closely associated with cardiovascular disease (CVD) in end stage renal (ESRD) patients. However, the clinical significance of pre-transplant arterial and impact kidney transplantation (KT) on have not yet been determined. Method We measured brachial-ankle pulse wave velocity (baPWV) before KT one year after KT. evaluated potential utility baPWV as a screening test to predict CVD. The progression was according changes factors that influence change were also...
Posaconazole is a new oral triazole with broad-spectrum antifungal activity.Posaconazole has also shown significant advantage of preventing invasive fungal infection compared to fluconazole or itraconazole in patients prolonged neutropenia.Indeed, posaconazole been commonly used for prophylaxis undergoing remission induction chemotherapy acute myelogenous leukemia myelodysplastic syndrome.We experienced case fatal mucormycosis despite prophylaxis.To our knowledge, this the first reported...
Cryptococcosis is an invasive fungal infection, which more common in immunocompromised patients. However, pulmonary cryptococcosis can occur immunocompetent patients and should be considered on a differential diagnosis for nodular or mass-like lesions chest radiograph. Recently, we experienced patient with cryptococcosis, successfully treated oral fluconazole therapy. A 74-year-old female was referred evaluation of abnormal images, large consolidative mass multiple consolidations small...
Experience of Advance Directives in a Hospice CenterTo protect patient autonomy when confronting death, the importance advance directives (ADs) has recently became an issue and gradually accepted Korea.However, real practice, ADs were not completed by patients but their families most cases.To analyze current situation performing ADs, we reviewed medical charts 214 terminal cancer admitted to hospice center from October 2012 September 2013.Seventy-six (35.5%) ADs.All themselves.The common...
Background/Aims: Patients who undergo repeat kidney transplantations (KTs) are considered at high risk for experiencing immunologic and non-immunologic complications. In this study, we investigated the clinical outcomes, including medical surgical complications, of patients underwent a third KT our center. Methods: Between March 1969 December 2012, total 2,110 KTs were performed Seoul St. Mary's Hospital. Of them, examined 11 KT, allograft outcomes complication rates. Results: The mean...
In the PALOMA-3 trial, median progression-free survival (PFS) was longer among patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC) treated palbociclib plus fulvestrant than those placebo fulvestrant. This subgroup analysis examined efficacy and safety of Korean enrolled in (n = 43 [palbociclib group, n 24; 19]). both groups, > 40% were pre/perimenopausal at enrollment. The PFS significantly prolonged vs. (12.3...
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