Marialena Chrysanthou
A5033871700- Renal cell carcinoma treatment
- Renal and related cancers
- Advanced Glycation End Products research
- Biochemical effects in animals
- Alzheimer's disease research and treatments
- Genetic and Kidney Cyst Diseases
- Natural Antidiabetic Agents Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Pediatric Urology and Nephrology Studies
Wageningen University & Research
2022-2024
Radboud University Nijmegen
2023
Radboud University Medical Center
2023
Radboud Institute for Molecular Life Sciences
2023
Advanced glycation end-products (AGEs) are products of a non-enzymatic reaction between amino acids and reducing sugars. Glycated human serum albumin (HSA) increases in diabetics as consequence elevated blood glucose levels glycating metabolites like methylglyoxal (MGO). The impact different types on the immunomodulatory properties HSA is poorly understood studied here. was glycated with D-glucose, MGO, or glyoxylic acid (CML). Glycation-related biochemical changes were characterized using...
Congenital anomalies of the kidney and urinary tract (CAKUT) are predominant cause for chronic disease below age 30 years. Many monogenic forms have been discovered due to comprehensive genetic testing like exome sequencing. However, disease-causing variants in known disease-associated genes only explain a proportion cases. Here, we aim unravel underlying molecular mechanisms syndromic CAKUT three unrelated multiplex families with presumed autosomal recessive inheritance. Exome sequencing...
Abstract Background Congenital anomalies of the kidney and urinary tract (CAKUT) are predominant cause for chronic disease below 30 years age. Many monogenic forms have been discovered mainly due to comprehensive genetic testing like exome sequencing (ES). However, disease-causing variants in known disease-associated genes still only explain a proportion cases. Aim this study was unravel underlying molecular mechanism syndromic CAKUT two multiplex families with presumed autosomal recessive...