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Alexandra V. Ligay

ORCID: 0000-0003-4851-779X
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About
Contact & Profiles
A5009353247
Research Areas
  • Immune cells in cancer
  • Atherosclerosis and Cardiovascular Diseases
  • Single-cell and spatial transcriptomics

University of Chicago
 2021

 Enhanced single-cell RNA-seq workflow reveals coronary artery disease cellular cross-talk and candidate drug targets
OPENALEX - Publications 
Wei Feng Chani J. Hodonsky Adam W. Turner Doris Wong Yipei Song and 17 more José Verdezoto Mosquera Alexandra V. Ligay Lotte Slenders Christina A. Gancayco Huize Pan Nelson B. Barrientos David Mai Gabriel F. Alencar Katherine Owsiany Gary K. Owens Muredach P. Reilly Mingyao Li Gerard Pasterkamp Michal Mokrý Sander W. van der Laan Bohdan B. Khomtchouk Clint L. Miller

The atherosclerotic plaque microenvironment is highly complex, and selective agents that modulate stability are not yet available. We sought to develop a scRNA-seq analysis workflow investigate this environment uncover potential therapeutic approaches. designed user-friendly, reproducible will be applicable other disease-specific datasets.Here we incorporated automated cell labeling, pseudotemporal ordering, ligand-receptor evaluation, drug-gene interaction into ready-to-deploy workflow....

10.1016/j.atherosclerosis.2021.11.025 article EN cc-by-nc-nd Atherosclerosis 2021-11-26
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