A5019445720- Electrospun Nanofibers in Biomedical Applications
- biodegradable polymer synthesis and properties
- Advanced Sensor and Energy Harvesting Materials
- Electrohydrodynamics and Fluid Dynamics
- Advanced Cellulose Research Studies
- Gynecological conditions and treatments
- 3D Printing in Biomedical Research
- Nanocomposite Films for Food Packaging
- Uterine Myomas and Treatments
- Polymer Surface Interaction Studies
- Surface Modification and Superhydrophobicity
- Advanced Drug Delivery Systems
- Microplastics and Plastic Pollution
- Neuroscience and Neural Engineering
- Surgical Sutures and Adhesives
- Endometriosis Research and Treatment
- Microencapsulation and Drying Processes
- Additive Manufacturing and 3D Printing Technologies
- Plant Surface Properties and Treatments
- Silk-based biomaterials and applications
- Drug Solubulity and Delivery Systems
- Corneal Surgery and Treatments
- Herpesvirus Infections and Treatments
- Nanofabrication and Lithography Techniques
- Botanical Research and Applications
Instituto de Salud Carlos III
2025
Instituto de Agroquímica y Tecnología de Alimentos
2018-2024
Asociación de Investigación de la Industria Agroalimentaria
2021-2024
INCLIVA Health Research Institute
2023
Loughborough University
2017-2021
Consejo Superior de Investigaciones Científicas
2018
The transmission of monkeypox virus occurs through direct contact, but saliva or exhaled droplets and aerosols has not yet been investigated. We aimed to assess the presence DNA infectious in samples from patients infected with virus.We did a cross-sectional study confirmed by PCR who attended two health centres Madrid, Spain. For each patient, we collected saliva, within mask, captured air filtration newly developed nanofiber filters. evaluated viral detection quantitative (qPCR) isolation...
Asherman's Syndrome is characterized by intrauterine adhesions or scarring, which cause infertility, menstrual abnormalities, and recurrent pregnancy loss. The pathophysiology of this syndrome remains unknown, with treatment restricted to surgical removal has limited success. Here, we decode the endometrial cell niche analyzing data from over 200,000 cells single-cell RNA-sequencing in patients condition through vitro analyses patient-derived organoids. Our atlas highlights loss epithelium,...
Electrospinning has been used to develop and upscale polyacrylonitrile (PAN) nanofibers as effective aerosol filtration materials for their potential use in respirators. The fibers were deposited onto non-woven spunbond polypropylene (SPP) the basis weight (grammage, g/m2) was varied assess resulting effect on efficiency breathing resistance of materials. results indicated that a excess 0.4 g/m2 PAN electrospun yielded over 97%, with values increased proportionally amount added. With aim...
This study reports on the development and characterization of organic recyclable high-oxygen-barrier multilayer films based different commercial polyhydroxyalkanoate (PHA) materials, including a blend with poly(butylene adipate-co-terephthalate) (PBAT), which contained an inner layer cellulose nanocrystals (CNCs) electrospun hot-tack adhesive poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) derived from cheese whey (CW). As result, full structures were made bio-based and/or compostable...
Surgical site infections (SSI) occur very frequently during post-operative procedures and are often treated with oral antibiotics, which may cause some side effects. This type of infection could be avoided by encapsulating antimicrobial/anti-inflammatory drugs within the surgical suture materials so that they can more efficiently act on action wound closure, avoiding bacterial spreading. work was aimed at developing novel electrospun bio-based anti-infective fibre-based yarns as for...
Active multilayer films based on polyhydroxyalkanoates (PHAs) with and without high barrier coatings of cellulose nanocrystals (CNCs) were herein successfully developed. To this end, an electrospun antimicrobial hot-tack layer made poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) derived from cheese whey, a by-product the dairy industry, was deposited previously manufactured blown film commercial food contact PHA-based resin. A hybrid combination oregano essential oil (OEO) zinc oxide...
Bacterial infections in the oral cavity can become a serious problem causing pain, sores and swelling for several weeks. This type of infection could be alleviated using mucoadhesive delivery systems, allowing local administration antibiotic to inhibit bacterial spreading. work reports development multilayer patch containing ciprofloxacin hydrochloride (CPX)-loaded electrospun fibers treatment such infections. For this, release kinetics CPX-loaded was modulated different ratios polyester...
In the present study, electrospun nanofibers of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), a biodegradable polyester, containing natural deep eutectic solvents (NADES) were obtained and reported for first time, exhibiting an unreported 3D morphology enhanced charge retention properties. Choline chloride (ChCl)/urea/water in molar ratio 1:2:1 was used as NADES model system. Electrospun produced from 10 wt % solution PHBV 26 with respect to polymer deposited on different substrates,...
Food quality is mainly affected by oxygen through oxidative reactions and the proliferation of microorganisms, generating changes in its taste, odor, color. The work presented here describes generation further characterization films with active scavenging properties made poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) loaded cerium oxide nanoparticles (CeO2NPs) obtained electrospinning coupled to a subsequent annealing process, which could be used as coating or interlayer multilayer...
The world of cosmetics is now aiming at biobased materials which are skin-compatible and can be used to generate more sustainable beauty masks with enhanced bioactivity. This work presents, in this line interest, the combination two innovative technologies, namely electrospinning dry powder impregnation, skin soluble electrospun pullulan carriers impregnated chitin nanofibrils-nanolignin-glycyrrethinic acid (CLA) complexes, as effective compatible masks. scalability carrier bioactive...
Electrospun fiber mats loaded with therapeutics have gained considerable attention as a versatile tool in the biomedical field. While these bandages are largely based on fast-dissolving polymers to release cargo, stimuli-responsive advantages of providing timely and spatially controlled drug delivery platform, which can be refilled reused several times. These benefits make electrospun patches original platforms for painless convenient on-demand hormone release. Because high need more...
<title>Abstract</title> Autologous CD133 + bone marrow-derived stem cell (BMDSC) therapy has been designated an Orphan Drug by the EMA and FDA for treatment of Asherman Syndrome (AS). This phase 1/2, non-randomized, open-label, single-arm trial assessed safety, efficacy biological plausibility this novel in 20 infertile women with moderate to severe AS unresponsive prior hysteroscopic treatments. The primary endpoint was doses ranging from 31 212 × 10⁶ cells being well tolerated; reversible...
A coating rendering superhydrophobic properties to low-density polyethylene (LDPE) films used in packaging applications was herein generated by means of the electrohydrodynamic processing (EHDP) technique. To this end, electrospun ultrathin poly(ε-caprolactone) (PCL) fibers, followed electrosprayed nanostructured silica (SiO2) microparticles, were deposited on top LDPE film. Various electrospinning and electrospraying times tested optimized a thermal post-treatment provide physical adhesion...
Interest in coated films with micro/nanofeatures has grown rapidly recent years due to their enhanced functional performance and better durability under demanding contact conditions or aggressive environments. In the current work, it is reported a one-step co-continuous bilayer coating process generate multilayer film that rendered superhydrophobicity polyethylene terephthalate (PET) substrate. A continuous based on ultrathin polylactide (PLA) fibers was deposited onto PET by means of...
Surgical site infections (SSI) occur very frequently during post-operatory procedures and are often treated with oral antibiotics, which may cause some side-effects. This type of could be avoided by encapsulating antimicrobial/anti-inflammatory drugs within the surgical suture materials so that these can more efficiently act on action wound closure, avoiding bacterial infection spreading. work was aimed at developing novel electrospun biobased anti-infective fiber-based yarns as for...
In this study, emulsion electrospraying assisted by pressurized gas (EAPG) has been performed for the first time to entrap ca. 760 nm droplets of bioactive eicosapentaenoic acid (EPA)-rich oil into whey protein concentrate (WPC) at room temperature. The submicron EPA were encapsulated within WPC spherical microparticles, with sizes around 5 µm. did not oxidize in course encapsulation 25 °C and presence air, as corroborated peroxide value measurements. Attenuated Total Reflection—Fourier...
The high-throughput drying and encapsulation technique called electrospraying assisted by pressurized gas (EAPG) was used for the first time to produce nanostructured valsartan within microparticles of excipients. Valsartan, a poorly absorbed lipid-soluble drug, selected since it is considered good model BCS class II drugs. Two different polymeric matrices were as excipients, i.e., hydroxypropyl methylcellulose (HPMC) lactose monohydrate, while Span 20 surfactant. produced 80% loading...
Conventional in vitro cultures are useful to represent simplistic neuronal behavior; however, the lack of organization results random neurite spreading. To overcome this problem, control over directionality SH-SY5Y cells was attained, utilizing photolithography pattern cell-repulsive anionic brush poly(potassium 3-sulfopropyl methacrylate) (PKSPMA) into tracks 20, 40, 80, and 100 μm width. These data validate use PKSPMA coatings for a long-term culture cells, as well providing methodology by...
Currently, consumers are demanding additive-free, fresher, and more-natural products. Dragon's Blood Sap (DBS), the deep red latex of specie tree Croton lechleri (Müll. Arg.), contains a high concentration phenolic compounds great interest for food, pharmaceutical, cosmetic industries. These chemical highly susceptible to degradation. Therefore, DBS storage stability its photo-oxidation was studied by Fourier transform infrared spectroscopy (FT-IR) UV-Vis spectrophotometry 39 days at...
The work herein presented aims to develop and characterize carvedilol (CVD) releasable non-water-soluble monolayers a multilayer patch made of ultrathin micron submicron fibers for drug delivery into the sublingual mucosa. Firstly, developed formulations containing CVD within different biopolymers (PDLA, PCL, PHB) were characterized by scanning electron microscopy (SEM), attenuated total reflectance Fourier transformed infrared spectroscopy (ATR-FTIR), differential calorimetry (DSC),...
In the current work, a super-repellent biopaper suitable for food contact applications was developed. To do this, three different kinds of biopolymers, namely polylactide (PLA), poly(ε-caprolactone) (PCL), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), and hydrophobic silica microparticles (SiO2), were sequentially processed by electrohydrodynamic processing (EDHP). As first step, ultrathin biopolymer fibers deposited onto commercial cellulose paper electrospinning and, thereafter,...
Digitally driven manufacturing technologies such as aerosol jet printing (AJP) can make a significant contribution to enabling new capabilities in the field of tissue engineering disease modeling and drug screening. AJP is an emerging non-contact mask-less process which has distinct advantages over other patterning it offers versatile, high-resolution, direct-write deposition variety materials on planar non-planar surfaces. This research demonstrates ability print digitally controlled...
Dragon’s blood sap (DBS) obtained from the bark of Croton lechleri (Müll, Arg.) is a complex herbal remedy pharmacological interest due to its high content in polyphenols, specifically proanthocyanidins. In this paper, electrospraying assisted by pressurized gas (EAPG) was first compared with freeze-drying dry natural DBS. Secondly, EAPG used for time entrap DBS at room temperature into two different encapsulation matrices, i.e., whey protein concentrate (WPC) and zein (ZN), using ratios...