A5079447268- Electrospun Nanofibers in Biomedical Applications
- Gut microbiota and health
- Surgical Sutures and Adhesives
- Wound Healing and Treatments
- Probiotics and Fermented Foods
- Electrohydrodynamics and Fluid Dynamics
- Neurogenesis and neuroplasticity mechanisms
- Salmonella and Campylobacter epidemiology
- Conducting polymers and applications
- Biochemical Analysis and Sensing Techniques
- Microfluidic and Capillary Electrophoresis Applications
- Electrochemical sensors and biosensors
- Reconstructive Surgery and Microvascular Techniques
- Antimicrobial agents and applications
- Bioactive natural compounds
- Biodiesel Production and Applications
- Nanocomposite Films for Food Packaging
- Hepatitis Viruses Studies and Epidemiology
- Viral gastroenteritis research and epidemiology
- Drug Solubulity and Delivery Systems
- Microplastics and Plastic Pollution
- Natural product bioactivities and synthesis
- Glioma Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Cells and Metastasis
Instituto de Agroquímica y Tecnología de Alimentos
2019-2024
Consejo Superior de Investigaciones Científicas
2024
University of L'Aquila
2015-2017
Sustainable packaging materials can play a key role in minimizing the environmental footprint of packaged food by preserving its quality and avoiding persistence plastic waste. Waste to wealth approach cope with these major challenges providing for bioavailable active compounds from waste residues. To this regard, humic substances (HS), derived biowaste oxidative processes, exhibit intrinsic antioxidant antimicrobial features, which be significantly boosted molecular combination an inorganic...
Surgical site infections (SSI) occur very frequently during post-operative procedures and are often treated with oral antibiotics, which may cause some side effects. This type of infection could be avoided by encapsulating antimicrobial/anti-inflammatory drugs within the surgical suture materials so that they can more efficiently act on action wound closure, avoiding bacterial spreading. work was aimed at developing novel electrospun bio-based anti-infective fibre-based yarns as for...
The data here reported introduce the wound-healing assay as a tool for testing probiotics aimed at protecting gastrointestinal mucosal surfaces and to verify consistency of their manufacturing. At scope, we compared in vitro effects two multi-strain high concentration formulations both commercialized under same brand VSL#3 but sourced from different production sites (USA Italy) on non-transformed small-intestinal epithelial cell line, IEC-6. cellular morphology, viability, migration, H2 O2...
The work presented herein focuses on the development and characterization of a transdermal caffeine platform fabricated from ultrathin micro- submicron fibers produced via electrospinning. formulations incorporated encapsulated in polyethylene oxide (PEO) matrix, combined with various permeation enhancers. A backing layer made annealed electrospun polycaprolactone (PCL) facilitated lamination two layers to form final patch. Comprehensive was conducted, utilizing scanning electron microscopy...
Surgical site infections (SSI) occur very frequently during post-operatory procedures and are often treated with oral antibiotics, which may cause some side-effects. This type of could be avoided by encapsulating antimicrobial/anti-inflammatory drugs within the surgical suture materials so that these can more efficiently act on action wound closure, avoiding bacterial infection spreading. work was aimed at developing novel electrospun biobased anti-infective fiber-based yarns as for...
Recently, glioma stem cells have been identified as the main cause of propagation and recurrence a number several cell markers indicated putative GSC markers. In present work, retrospective study to evaluate prognostic potential ability generate GSCs in our series 15 glioblastoma patients is described. β-tubulin III, nestin, CD133, GFAP, SOX-2 marker expression, both primary GBM cultures respective (GSCs), was evaluated by flow cytometric analysis. Our results demonstrated various expression...
The high-throughput drying and encapsulation technique called electrospraying assisted by pressurized gas (EAPG) was used for the first time to produce nanostructured valsartan within microparticles of excipients. Valsartan, a poorly absorbed lipid-soluble drug, selected since it is considered good model BCS class II drugs. Two different polymeric matrices were as excipients, i.e., hydroxypropyl methylcellulose (HPMC) lactose monohydrate, while Span 20 surfactant. produced 80% loading...
An artificial wound in a confluent monolayer of human keratinocyte HaCaT cells or mouse embryo fibroblast Swiss NIH 3T3 was used to analyze the effects nitric oxide (NO) chemical donor, S-nitroso-N-acetylpenicillamine (SNAP). SNAP exposure promoted an enhanced rate closure and accelerated motility both keratinocytes fibroblasts compared control cells. The wounded cultures cells, treated with without SNAP, were monitored under phase contrast microscope. Structural ultrastructural...
A high throughput encapsulation technique termed as electrospraying assisted by pressurized gas technology (EAPG) was used to produce nano-within-micro structures of a Biopharmaceutics Classification System (BCS) Class II model drug. Carvedilol is lipid soluble compound, poorly absorbed in the gastrointestinal tract. The produced formulations were characterized terms morphology, crystallinity, vitro dissolution test, Caco-2 cells permeability and vivo pharmacokinetics rats. Spherical...
Aim: This study aimed to isolate, characterize, and encapsulate a lupeol-rich fraction obtained from the hexanic extract of Coccoloba uvifera L. leaves evaluate its potential use in nutraceutical or pharmaceutical applications. Methods: The C. leaf was fractionated by column chromatography presence lupeol assessed thin layer chromatography, attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy, nuclear magnetic resonance (NMR), liquid chromatography-mass spectrometry...
The metabolic disturbances of obesity can be mitigated by strategies modulating the gut microbiota. In this study, we sought to identify whether innate or adaptive immunity mediates beneficial effects human intestinal bacterium Bacteroides uniformis CECT 7771 in obesity. We evaluated orally administered B. on energy homeostasis, immunity, hormone levels, and microbiota wild-type Rag1-deficient mice with diet-induced also assessed needed viable exert its directly induce immunoregulatory...
A probiotic is defined as a "live microorganism which when administered in adequate amounts confers health benefit on the host".There growing interest probiotics within scientific community, with consumers, and food industry.Thus, large body of literature exploring mechanisms action strains their effects human actually available.In last twenty years, our research group has been pledged to study cellular molecular underlying beneficial selected probiotics.Here, we retrace most significant...