A5021481645- Cancer Mechanisms and Therapy
- TGF-β signaling in diseases
- Drug-Induced Hepatotoxicity and Protection
- Lipid metabolism and disorders
- Computational Drug Discovery Methods
- MicroRNA in disease regulation
- COVID-19 Clinical Research Studies
- Liver physiology and pathology
- Peroxisome Proliferator-Activated Receptors
- Genomics, phytochemicals, and oxidative stress
- SARS-CoV-2 and COVID-19 Research
Anhui Medical University
2018-2021
Ministry of Education of the People's Republic of China
2018
Salvianolic acid B (Sal B) has strong antioxidant and anti-fibrosis effects, which are related to the transforming growth factor β/Smad signaling pathway. However, how Sal affects this pathway phosphorylation (p-) of Smad2 at both COOH-terminal (pSmad2C) linker region (pSmad2L) unknown. The aims present study were investigate underlying mechanisms on acute chronic liver injury induced by CCl<sub>4</sub> H<sub>2</sub>O<sub>2</sub>, its effects p-Smad2C/L. In <em>in vivo</em> experiments,...
Salvianolic acid B (Sal B) exerts strong antioxidant activity and eliminates the free radical effect. However, how it affects pathway is not very clear. The objective of this study was to investigate underlying mechanism Sal in CCl 4 -induced acute liver injury, especially its effect on Nrf2/HO-1 signaling pathway. For vivo experiment, an injury model induced using treated with B. vitro oxidative damage established followed by treatment. Serum biochemical indicators reactive oxygen species...
目的观察丹酚酸B(salvianolic acid B，Sal B)对二乙基亚硝胺(diethylnitrosamine, DEN)诱导小鼠肝纤维化-肝细胞癌进程的影响，并探讨Sal B经由pSmad3C/p21介导的抑癌信号、pSmd3L/PAI-1/c-Myc介导的促肝纤维化-肝癌信号转换机制。 方法昆明种♂小鼠100只, 随机分组，DEN诱导小鼠肝纤维化-肝细胞癌模型，不同剂量Sal B(15、30 mg·kg-1·d-1，ig)及阳性药秋水仙碱(0.2 mg·kg-1·d-1，ig)干预。于造模第12周、第16周分批处死小鼠，肝脏活检，苏木精-伊红(HE)染色、Van Gieson(VG)染色观察肝组织病理学特征，Western blot法检测肝组织中pSmad3C、pSmad3L、p21、纤溶酶原激活物抑制剂-1(plasminogen activator inhibitor 1，PAI-1)及c-Myc蛋白表达。...