A5049059749- SARS-CoV-2 and COVID-19 Research
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Carbohydrate Chemistry and Synthesis
- Computational Drug Discovery Methods
- Cyclopropane Reaction Mechanisms
- Viral Infections and Immunology Research
- Atmospheric chemistry and aerosols
- Chemical Synthesis and Analysis
- Viral gastroenteritis research and epidemiology
- Air Quality Monitoring and Forecasting
- COVID-19 Clinical Research Studies
- Cancer, Hypoxia, and Metabolism
- Enzyme Catalysis and Immobilization
- Cryptography and Data Security
- Catalytic Cross-Coupling Reactions
- Vehicle emissions and performance
- Advanced materials and composites
- Click Chemistry and Applications
- Amino Acid Enzymes and Metabolism
- Odor and Emission Control Technologies
- Advanced Fluorescence Microscopy Techniques
- Alkaloids: synthesis and pharmacology
- Morinda citrifolia extract uses
- Advanced Wireless Communication Technologies
Shanghai Institute of Materia Medica
2016-2025
Chinese Academy of Sciences
2016-2025
University of Chinese Academy of Sciences
2020-2025
Huazhong Agricultural University
2025
Nanjing University of Chinese Medicine
2024
Ministry of Natural Resources
2024
Jilin University
2022-2024
Fudan University
2023
Zhengzhou University
2023
Institute of Geology, China Earthquake Administration
2022
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is the etiological agent responsible for global COVID-19 (coronavirus disease 2019) outbreak. The main protease of SARS-CoV-2, Mpro, a key enzyme that plays pivotal role in mediating viral replication and transcription. We designed synthesized two lead compounds (11a 11b) targeting Mpro Both exhibited excellent inhibitory activity potent anti-SARS-CoV-2 infection activity. x-ray crystal structures complex with 11a or 11b, both...
Long Stokes shift dyes that minimize cross-talk between the excitation source and fluorescent emission to improve signal-to-background ratio are highly desired for fluorescence imaging. However, simple small molecular with large (more than 120 nanometers) near-infrared (NIR) emissions have been rarely reported so far. Here, inspired by chromophore chemical structure of proteins, we designed synthesized a series styrene oxazolone (SODs) synthetic methods, which show NIR (>650 long (ranged...
A novel series of peptidomimetic aldehydes was designed and synthesized to target 3C protease (3Cpro) enterovirus 71 (EV71). Most the compounds exhibited high antiviral activity, among them, compound 18p demonstrated potent enzyme inhibitory activity broad-spectrum on a panel enteroviruses rhinoviruses. The crystal structure EV71 3Cpro in complex with determined at resolution 1.2 Å revealed that covalently linked catalytic Cys147 an aldehyde group. In addition, these also good against 3CLpro...
Abstract Respiratory disease caused by coronavirus infection remains a global health crisis. Although several SARS-CoV-2-specific vaccines and direct-acting antivirals are available, their efficacy on emerging coronaviruses in the future, including SARS-CoV-2 variants, might be compromised. Host-targeting provide preventive therapeutic strategies to overcome resistance manage future outbreak of coronaviruses. Cathepsin L (CTSL) calpain-1 (CAPN1) host cysteine proteases which play crucial...
An efficient Rh(III)-catalyzed C–H alkenylation/directing group migration cascade between indoles and alkynes for the assembly of tetrasubstituted alkenes is reported. The carbamoyl directing migrates to carbon alkene moiety products through rare Rh-catalyzed C–N bond cleavage after alkenylation step thus acts as an internal amidation reagent. This protocol shows broad substrate scope, excellent regio/stereoselectivity, good yields.
Among C-glycosides, C-alkyl glycosides are significant building blocks for natural products and glycopeptides. However, research on efficient construction methods remains relatively limited. Compared with Michael acceptors, non-activated olefins more challenging substrates have rarely been employed in the of C-glycosides. Here, a highly convenient approach synthesis through nickel-catalyzed C(sp
SUMMARY Anthocyanins, the important antioxidants and signaling molecules, are natural polyphenolic compounds widely present in plants essential for plant defense. However, little is known about mechanisms underlying anthocyanin accumulation relation to drought stress. This study reveals that stress induces significant Rosa chinensis , alongside an increase expression of MYB transcription factor (TF) gene RcMYB75 glutathione S‐transferase (GST) RcGSTFL11 . When overexpressed, markedly...
Unnatural (R)-α-amino acids (α-AAs) are in growing demand the biomedical research and pharmaceutical industries. In this work, we present development of a purely chemical approach for preparation (R)-α-AAs via (S)-to-(R)-interconversion natural tailor-made (S)-α-AAs. The method can be used on free, unprotected α-AAs features remarkable structural generality including substrates bearing tertiary alkyl chains reactive functional groups. These attractive characteristics, combined with...
An efficient approach to obtain saturated seven-membered ring containing three heteroatoms has been developed by using a palladium-catalyzed [4 + 3] dearomatizing cycloaddition. This features mild conditions and good functional group tolerance.
A novel strategy is reported for the construction of 2-hydroxy-2′-amino-1,1′-biaryl scaffolds <italic>via</italic> Ir(<sc>iii</sc>)-catalyzed direct C–H bond activation under mild reaction conditions.
ABSTRACT SARS-CoV-2 is the etiological agent responsible for COVID-19 outbreak in Wuhan. Specific antiviral drug are urgently needed to treat infections. The main protease (M pro ) of a key CoV enzyme that plays pivotal role mediating viral replication and transcription, which makes it an attractive target. In effort rapidly discover lead compounds targeting M , two ( 11a 11b were designed synthesized, both exhibited excellent inhibitory activity with IC50 value 0.05 μM 0.04 respectively....
Abstract We have developed a highly efficient and practical approach for palladium‐catalyzed trifluoroacetate‐promoted N‐quinolylcarboxamide‐directed glycosylation of inert β‐C(sp 3 )−H bonds N‐phthaloyl α‐amino acids with glycals under mild conditions. For the first time, C(sp activation was achieved to build C‐alkyl glycosides. This method facilitates synthesis various β‐substituted glycoamino offers tool glycopeptide synthesis.
Sacha inchi (Plukenetia volubilis L.) tea has been used as an adjuvant treatment for diabetes in Pu'er, the Yunnan province of China. The effects sacha on and underlying mechanisms remain unknown. This study was conducted to investigate influence a water extract (P. leaves (PWE) hypoglycemic activity gut microbiota composition mice with streptozotocin (STZ)-induced type 1 mellitus (T1DM). During 6 weeks study, T1DM were administered PWE intragastrically at 400 mg kg-1 body weight (BW) per...
In this paper, a novel carrier index differential chaos shift keying (DCSK) modulation system is proposed for increased energy and spectral efficiencies. The new splits all data bits into two groups, which are carried by the chaotic signals their Hilbert transforms, respectively. For each group, one active subcarrier selected from candidate subcarriers according to bits, signal transmitted via carries modulated bit through DCSK modulation. By correlating with exact or filtered reference...
Human noroviruses (HuNoVs) are the most common cause of viral gastroenteritis resulting annually in ~219,000 deaths and a societal cost ~USD 60 billion, no antivirals or vaccines available. Here, we assess anti-norovirus activity new peptidomimetic aldehydes related to protease inhibitor rupintrivir. The early hit compound 4 inhibited replication murine norovirus (MNV) HuNoV GI.1 replicon vitro (EC50 ~1 µM) swiftly cleared from cells. Compound still inhibits proteolytic activity. We selected...