Abstract The low-temperature thermoelectric performance of Bi-rich n-type Mg 3 (Bi,Sb) 2 was limited by the electron transport scattering at grain boundaries, while removing boundaries and bulk crystal growth Mg-based Zintl phases are challenging due to volatilities elemental reactants their severe corrosions crucibles elevated temperatures. Herein, for first time, we reported a facile coarse-grained Bi 2- x Sb crystals with an average size ~800 μm, leading high carrier mobility 210 cm · V...

Encapsulation technology has been extensively used to enhance the stability, specificity, and bioavailability of essential food ingredients. Additionally, it plays a vital role in improving product quality reducing production costs. This study presents comprehensive classification encapsulation techniques based on state different cores (solid, liquid, gaseous) offers detailed description analysis these methods. Specifically, introduces diverse applications food, encompassing areas such as...

Internal alkynes have been used widely in transition-metal-catalyzed cycloaddition reactions, which they generally serve as two-carbon reaction partners. Herein, we report ruthenium(II)-catalyzed redox-neutral [4 + 1] annulation of benzamides and propargyl alcohols, alcohols act one-carbon units. This synthetic utility led to a series potentially bioactive N-substituted quaternary isoindolinones with moderate high yields under mild conditions. Without the requirement for an external metal...

Organophosphorus flame retardants (OPFRs) have been increasingly used in various building and decoration materials to fulfill fire safety standards since the phasing out of polybrominated diphenyl ethers. We determined OPFR concentrations most commonly available local markets online China. The varied significantly, from 14.78 ng/g (putty powder) 9649000 (expanded polystyrene panel (EPS)). Relatively high OPFRs were found foam samples, followed by nonwoven polyvinyl chloride (PVC) wallpaper,...

Herein, rhodium(III)-catalyzed C–H activation/subsequent [4 + 1] cyclization reactions between benzamides and propargyl alcohols are reported in which serve as unusual one-carbon units. This title transformation led to a series of isoindolinones bearing quaternary carbon with moderate good yields without the requirement for external metal oxidants. Due mild simple reaction conditions, this is compatible various functional groups.

Herein, we report a rhodium-catalyzed C–H activation/[4+2] cyclization reaction between α,β-unsaturated amides and iodonium ylides for the synthesis of novel 7,8-dihydroquinoline-2,5-diones analogues. This protocol provides series pyridones fused with saturated cycles good functional group compatibility, water air tolerance, to excellent yields under mild green conditions. Additionally, scale-up can be smoothly performed as low 0.25 mol % catalyst loading. Recycling experiments different...

Indole-fused polycycles are common in natural products and bioactive molecules, yet their concise efficient synthesis remains challenging, especially for compounds with multiple stereocenters. Herein, we report the application of a chiral CpxRhIII catalyst enantioselective C–H activation/[4+2] annulation indoles bicyclic alkenes. This catalytic system exhibits high enantioselectivity broad functional group tolerance operates under benign conditions. The scope this methodology encompasses...

The development of an efficient approach to construct fused polycyclic systems bearing a quaternary carbon center represents great challenge synthetic chemistry. Herein, we report Rh(III)-catalyzed [4 + 1] annulation propargyl alcohols with various heterocyclic scaffolds under air atmosphere. Diverse heterocycles containing were obtained in moderate good yields. Additionally, this method features high atom-economy, metal oxidant free, simple operation, and compatibility functional groups.

Herein, we report the additive-controlled divergent synthesis of tetrasubstituted 1,3-enynes and alkynylated 3H-pyrrolo[1,2-a]indol-3-ones through rhodium-catalyzed C-H alkenylation/DG migration [3+2] annulation, respectively. This protocol features rare directing group in 1,3-diyne-involved activation, excellent regio- stereoselectivity, monofunctionalization over difunctionalization, broad substrate scope, moderate to high yields, good functional compatibility, mild redox-neutral conditions.

Herein, we report a rare example of rhodium-catalyzed C–H activation/[4 + 2] annulation alkenyl amides with bicyclic alkenes under mild and green conditions. The reactivity the rhodium catalyst in this study differed from that observed cobalt-catalyzed activation/[3 between vinylic alkenes. In addition, reaction was performed EtOH at room temperature, which also displayed excellent diastereoselectivity, good functional group tolerance, air compatibility. A series novel bridged-ring skeletons...

An efficient Rh(III)-catalyzed C–H alkenylation/directing group migration cascade between indoles and alkynes for the assembly of tetrasubstituted alkenes is reported. The carbamoyl directing migrates to carbon alkene moiety products through rare Rh-catalyzed C–N bond cleavage after alkenylation step thus acts as an internal amidation reagent. This protocol shows broad substrate scope, excellent regio/stereoselectivity, good yields.

Herein, we report the divergent synthesis of alkynylated imidazo[1,5-a]indoles and α,α-difluoromethylene tetrasubstituted alkenes through Rh(III)-catalyzed [4 + 1] annulation/alkyne moiety migration C–H alkenylation/DG migration, respectively. This protocol features tunable product selectivity, excellent chemo-, regio-, stereoselectivity, broad substrate scope, moderate to high yields, good tolerance functional groups, mild redox-neutral conditions.

Flaviviruses, including Zika, dengue, and West Nile viruses, are important human pathogens. The highly conserved NS2B-NS3 protease of Flavivirus is essential for viral replication therefore a promising drug target. Through compound screening, followed by medicinal chemistry studies, novel series 2,5,6-trisubstituted pyrazine compounds found to be potent, allosteric inhibitors Zika virus (ZVpro) with IC50 values as low 130 nM. Their structure-activity relationships discussed. ZVpro also...

SnSe-based compounds, as promising thermoelectric materials, are well-known for their intrinsically low thermal conductivity and outstanding performance. However, the suboptimal electrical transport capacity n-type polycrystalline SnSe significantly hinders improvement of its In this work, an effective approach enhancing performance materials through ZnCl2 doping has been investigated. The enhanced density state mass, which is related to introduction impurity level facilitation multivalley...

Herein, an efficient Rh-catalyzed C-H activation/annulation between α,β-unsaturated amides and coumarin-derived iodonium ylides has been developed, affording novel pyrano[3,2-c]chromene-2,5-diones analogues in high yields. Most products could be easily isolated by precipitation ethanol, followed simple filtration. Additionally, this protocol demonstrated the benefits of environmentally friendly conditions, air compatibility, good functional group scale-up synthesis with low catalyst loading,...

Ru(II)-catalyzed redox-neutral [3+2] annulation reactions of N-ethoxycarbamoyl indoles and internal alkynes via C-H bond activation are reported. This method features a broad alkyne scope, including various aryl/alkyl-, alkyl/alkyl-, diaryl-substituted alkynes, good to excellent regioselectivity, diverse functional group tolerance, mild reaction conditions. The directing group, temperature, CsOAc, ruthenium catalyst proved be crucial for conversion high regioselectivity. Additionally,...

A ruthenium-catalyzed C–H allylation of indoles with allyl alcohols via β-hydroxide elimination is reported. Without external oxidants and expensive additives, this reaction features mild conditions, compatibility various functional groups, good to excellent regioselectivity stereoselectivity.

Recently, N-hydroxyindole derivatives have received much interest because of their unique structural motif and various biological activities. In this study, we report the first example a Rh(III)-catalyzed reaction arylnitrones with α-diazoketoesters or α-diazodiketones to produce derivatives. Intriguingly, could build scaffold by blocking cleavage N–O bond selectively, while eliminating acyl group preferentially.

Abstract Herein, an efficient and regioselective Rh(III)‐catalyzed [4+2] annulation/lactonization cascade of indoles with 4‐hydroxy‐2‐alkynoates at room temperature to access the furo[3′,4′:4,5]pyrimido[1,6‐ a ]indole‐1,5(3 H ,4 )‐diones is described. This method features mild reaction conditions, operational simplicity, excellent regioselectivity, broad substrate scope good functional group tolerance, yields. magnified image