A5047999771- Viral Infections and Immunology Research
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Cancer-related Molecular Pathways
- Malaria Research and Control
- Insect symbiosis and bacterial influences
- T-cell and Retrovirus Studies
- Mosquito-borne diseases and control
- Cervical Cancer and HPV Research
Ghent University Hospital
2024
University of Thessaly
2018-2023
Rega Institute for Medical Research
2021
KU Leuven
2021
Human myxovirus resistance 2 (MX2) can restrict HIV-1 and herpesviruses at a post-entry step through process requiring an interaction between MX2 the viral capsids. The involvement of other host cell factors, however, remains poorly understood. Here, we mapped proximity interactome MX2, revealing strong enrichment phenylalanine-glycine (FG)-rich proteins related to nuclear pore complex as well that are part cytoplasmic ribonucleoprotein granules. interacted with these form multiprotein...
Human noroviruses (HuNoVs) are the most common cause of viral gastroenteritis resulting annually in ~219,000 deaths and a societal cost ~USD 60 billion, no antivirals or vaccines available. Here, we assess anti-norovirus activity new peptidomimetic aldehydes related to protease inhibitor rupintrivir. The early hit compound 4 inhibited replication murine norovirus (MNV) HuNoV GI.1 replicon vitro (EC50 ~1 µM) swiftly cleared from cells. Compound still inhibits proteolytic activity. We selected...
West Nile virus (WNV) is an emerging neurotropic RNA and a member of the genus Flavivirus. Naturally, maintained in enzootic cycle involving mosquitoes as vectors birds that are principal amplifying hosts. In humans, incubation period for WNV disease ranges from 3 to 14 days, with estimated 80% infected persons being asymptomatic, around 19% developing mild febrile infection less than 1% neuroinvasive disease. Laboratory diagnosis generally accomplished by cross-reacting serological methods...
Purpose. The tumour suppressor protein RB plays a decisive role in negative control of the cell cycle, inhibiting development. present analysis investigated prevalence nucleotide polymorphism A153104G, which is located at intron 18 RB1 gene, and impact polymorphic variability exon 19 its flanking intronic sequences on severity cervical disease HPV16-positive Greek women. Methodology. A153104G was detected by PCR-RFLP assay, while amplicons were further subjected to cloning sequencing....