A5088638618- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Radiopharmaceutical Chemistry and Applications
- Zebrafish Biomedical Research Applications
- Child Nutrition and Water Access
- Neuroscience and Neuropharmacology Research
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Marine Toxins and Detection Methods
Rega Institute for Medical Research
2021-2024
KU Leuven
2021-2024
Chronic human norovirus (HuNoV) infections in immunocompromised patients result severe disease, yet approved antivirals are lacking. RNA-dependent RNA polymerase (RdRp) inhibitors inducing viral mutagenesis display broad-spectrum vitro antiviral activity, but clinical efficacy HuNoV is anecdotal and the potential emergence of drug-resistant variants concerning. Upon favipiravir (and nitazoxanide) treatment four with life-threatening infections, whole-genome sequencing showed accumulation...
Human noroviruses (HuNoVs) are the most common cause of viral gastroenteritis resulting annually in ~219,000 deaths and a societal cost ~USD 60 billion, no antivirals or vaccines available. Here, we assess anti-norovirus activity new peptidomimetic aldehydes related to protease inhibitor rupintrivir. The early hit compound 4 inhibited replication murine norovirus (MNV) HuNoV GI.1 replicon vitro (EC50 ~1 µM) swiftly cleared from cells. Compound still inhibits proteolytic activity. We selected...
PharmaSea performed large-scale in vivo screening of marine natural product (MNP) extracts, using zebrafish embryos and larvae, to identify compounds with the potential treat epilepsy. In this study, we report discovery two new antiseizure compounds, 2,5-diketopiperazine halimide its semi-synthetic analogue, plinabulin. Interestingly, these are both known microtubule destabilizing agents, plinabulin could have for drug repurposing, as it is already clinical trials prevention...
Human noroviruses (HuNoVs) are a major cause of diarrheal disease, yet critical aspects their biology, including cellular tropism, remain unclear. Although research has traditionally focused on the intestinal epithelium, hypothesis that HuNoV infects macrophages been recurrently discussed and is investigated here using zebrafish larval model. Through single-cell RNA sequencing dissected intestines, we unbiasedly identified as host cells for replication, with all three open reading frames...