A5048865555- Semantic Web and Ontologies
- Pregnancy and preeclampsia studies
- Cancer Risks and Factors
- Muscle Physiology and Disorders
- CRISPR and Genetic Engineering
- Aldose Reductase and Taurine
- Pancreatic function and diabetes
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Pluripotent Stem Cells Research
- Endoplasmic Reticulum Stress and Disease
- Renal Transplantation Outcomes and Treatments
- Service-Oriented Architecture and Web Services
- Amino Acid Enzymes and Metabolism
- Birth, Development, and Health
- Pregnancy-related medical research
- RNA modifications and cancer
- Transplantation: Methods and Outcomes
- Data Mining Algorithms and Applications
- Cytomegalovirus and herpesvirus research
- Virus-based gene therapy research
- Polyamine Metabolism and Applications
- Child Nutrition and Water Access
- Advanced Database Systems and Queries
- Viral gastroenteritis research and epidemiology
KU Leuven
2018-2024
Polyamines, such as putrescine, spermidine, and spermine, are physiologically important polycations, but the transporters responsible for their uptake in mammalian cells remain poorly characterized. Here, we reveal a new component of polyamine transport system using CHO-MG cells, widely used model to study alternative routes characterize inhibitors therapy. present deficiency resistance toxic biosynthesis inhibitor methylglyoxal bis-(guanylhydrazone) (MGBG), molecular defects these cellular...
Duchenne Muscular Dystrophy (DMD) is an X-linked neuromuscular disease which to date incurable. The major cause of death dilated cardiomyopathy however, its pathogenesis unclear as existing cellular and animal models do not fully recapitulate the human phenotypes. In this study, we generated cardiac organoids from patient-derived induced pluripotent stem cells (DMD-COs) isogenic-corrected controls (DMD-Iso-COs) studied if DMD-related progression occur in upon long-term culture (up 93 days)....
Kidney transplant injury processes are associated with molecular changes in kidney tissue, primarily related to immune cell activation and infiltration. How these reflected the circulating cells, whose is targeted by strong immunosuppressants, poorly understood. To study this, we analyzed alterations 384 peripheral blood samples from four European centers, taken at time of a allograft biopsy, selected for their phenotype, using RNA-sequencing. In blood, differentially expressed genes 136...
Abstract Although immune checkpoint blockade (ICB) has revolutionized cancer treatment, resistance mechanisms limit its clinical benefit. Here we characterise LISRR , a cancer-specific lncRNA highly expressed in melanoma patients refractory to ICB. In cells undergoing (therapeutic) stress, recruits DAZAP1 (Deleted AZoospermia Associated Protein 1) polysomes and drives the assembly of subset ribosomes at endoplasmic reticulum, directing synthesis an immunosuppressive translatome. This...
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Human noroviruses (HuNoVs) are a major cause of diarrheal disease, yet critical aspects their biology, including cellular tropism, remain unclear. Although research has traditionally focused on the intestinal epithelium, hypothesis that HuNoV infects macrophages been recurrently discussed and is investigated here using zebrafish larval model. Through single-cell RNA sequencing dissected intestines, we unbiasedly identified as host cells for replication, with all three open reading frames...
Abstract Duchenne Muscular Dystrophy (DMD) is an X-linked neuromuscular disease which to-date incurable. The major cause of death dilated cardiomyopathy, however the pathogenesis unclear as existing cellular and animal models do not fully recapitulate human phenotypes. In this study, we generated cardiac organoids from patient-derived pluripotent stem cells (DMD-CO) isogenic-corrected controls (DMD-Iso-CO) studied if DMD-related cardiomyopathy progression occur in upon long-term culture (up...