A5031773609- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Calpain Protease Function and Regulation
- Synthesis and biological activity
- Pharmacological Effects of Natural Compounds
- interferon and immune responses
- Enzyme Structure and Function
ShanghaiTech University
2021-2024
University of Chinese Academy of Sciences
2024
Tsinghua University
2024
The main protease (Mpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a key enzyme, which extensively digests CoV replicase polyproteins essential for viral replication and transcription, making it an attractive target antiviral drug development. However, the molecular mechanism how Mpro SARS-CoV-2 polyproteins, releasing nonstructural proteins (nsps), its substrate specificity remain largely unknown. Here, we determine high-resolution structures in resting state,...
Abstract Respiratory disease caused by coronavirus infection remains a global health crisis. Although several SARS-CoV-2-specific vaccines and direct-acting antivirals are available, their efficacy on emerging coronaviruses in the future, including SARS-CoV-2 variants, might be compromised. Host-targeting provide preventive therapeutic strategies to overcome resistance manage future outbreak of coronaviruses. Cathepsin L (CTSL) calpain-1 (CAPN1) host cysteine proteases which play crucial...