The effects of estrogens, particularly 17beta-estradiol (E2), are mediated by estrogen receptor alpha (ERalpha) and ERbeta. Upon binding to E2, ERs homo- heterodimerize when coexpressed. ER dimer then regulates the transcription target genes through responsive element (ERE)-dependent -independent pathways that constitute genomic signaling. Although ERalpha ERbeta have similar ERE E2 properties, they display different transregulatory capacities in both ERE-dependent signaling pathways. It is...

Heavy metal pollution in the environment is mostly manifested as a multi-elemental compound pollution. The effect of long-term exposure to heavy on gut microbes insects has remained unknown. For current work, population Eucriotettix oculatus living mining areas around Diaojiang River with history hundreds years pollution, was selected along similar species non-mining conduct comparative study their microbes. microbial communities were analyzed using 16S rRNA amplicon sequencing. results...

To study the heavy metal accumulation and its impact on insect exterior chromosome morphology, reveal molecular mechanism of insects adapting to long-term compound pollution habitats, this study, in Diaojiang river basin, which has been polluted by metals(HMs) for nearly a thousand years, two Eucriotettix oculatus populations was collected from mining non-mining areas. It found that contents 7 metals (As, Cd, Pb, Zn, Cu, Sn, Sb) E. area were higher than 1–11 times. The analysis morphology...

The gut microbiome significantly influences the health and productivity of silkworms (

Long term video game players (VGPs) exhibit superior visual and motor skills compared with non-video control subjects (NVGCs). However, the neural basis underlying enhanced behavioral performance remains largely unknown. To clarify this issue, present study whiter matter integrity within corticospinal tracts (CST), longitudinal fasciculus (SLF), inferior (ILF), fronto-occipital (IFOF) between VGPs NVGCs using diffusion tensor imaging. Compared NVGCs, voxel-wise comparisons revealed...

The functions of 17beta-estradiol (E2) are mediated by estrogen receptor (ER) alpha and beta. ERs display similar DNA- ligand-binding properties in vitro. However, ERbeta shows lower transcriptional activity than ERalpha from the response element (ERE)-dependent signaling. We predicted that distinct amino termini contribute to differences transcription efficacies affecting situ ER-ERE interactions. used chromatin immunoprecipitation a novel ERE competition assay, which is based on ability ER...

The response mechanism of plants under long-term heavy metal stress is not fully understood. This study compared and analyzed Pteris vittata L. the mining areas, which significantly enriched multiple metals (As, Cd, Hg, Pb, Zn, Cu, Sn, Sb, Cr), with those in non areas. transcriptome analysis results showed that there were 1226 genes upregulated 1801 downregulated area. Functional enrichment these differentially expressed indicates stress, gene expression related biological pathways such as...

Many physiological functions in crustaceans adapt to daily environmental change through circadian changes. However, the variation of gut bacterial community composition has not been reported for crustaceans. In this study, we aimed identify and elaborate on 24 h dynamic variations Chinese mitten crab (Eriocheir sinensis). To end, processed samples from crabs collected at four time points (6:00, 12:00, 18:00, 24:00) a period applied 16 S rRNA high-throughput gene sequencing. The...

Estrogen (E2) signaling is conveyed by the transcription factors estrogen receptor (ER) alpha and beta. ERs modulate expression of genes involved in cellular proliferation, motility, death. The regulation E2-ERalpha through binding to estrogen-responsive elements (EREs) DNA constitutes ERE-dependent pathway. also modulates gene interacting with transregulators bound cognate DNA-regulatory elements, this referred as ERE-independent relative importance pathway unclear. To address issue, we...

The gut microbiota, a complex ecosystem integral to host wellbeing, is modulated by environmental triggers, including exposure heavy metals such as chromium. This study aims comprehensively explore chromium-induced microbiota and metabolomic shifts in the quintessential lepidopteran model organism, silkworm (Bombyx mori). research deployed 16S rDNA sequence analysis LC/MS metabolomics its experimental design, encompassing control group alongside low (12 g/kg) high (24 feeding chromium dosing...

Background: Darier disease is an autosomal dominant hereditary skin that susceptible to secondary bacterial or fungal infections, but rarely human papillomavirus (HPV) infections. Multiple extensive warts from HPV remain a therapeutic challenge, local hyperthermia effective. We treated patient with who had superimposed in the genital and neck regions.Materials methods: The was tolerable infrared light halogen lamp (surface temperature, 40°C) single target lesion on genitalia (30 min daily)...

Scelimeninae is a key member of the pygmy grasshopper community, and an important ecological indicator. No mitochondrial genomes have been reported to date, monophyly its phylogenetic relationship within Tetrigidae still unclear. We sequenced analyzed eight nearly complete representing genera Scelimeninae. These mitogenomes ranged in size from 13,112 16,380 bp order tRNA genes between COII ATP8 was reversed compared with ancestral insects. The protein-coding (PCGs) tetrigid species mainly...

The pygmy grasshoppers, which belong to the superfamily Tetrigoidea, exhibit remarkable environmental adaptability. However, no study has yet reported a reference genome for this group. In study, we assembled high-quality chromosome-scale of Eucriotettix oculatus, survive in environment heavily polluted by heavy metals, achieved through Illumina and PacBio sequencing, alongside chromosome conformation capture techniques. resulting spans 985.45 Mb across seven chromosomes (range: 71.55 266.65...

Galactitol synthetase (GolS) as a key enzyme in the raffinose family oligosaccharides (RFOs) biosynthesis pathway, which is closely related to stress. At present, there are few studies on GolS biological The expression of MnGolS2 gene mulberry was increased under Botrytis cinerea infection. cloned and ectopically expressed Arabidopsis. content MDA leaves transgenic plants decreased CAT after inoculation with B. cinerea. In this study, role biotic stress demonstrated for first time. addition,...

The genus Scelimena Serville (Orthoptera: Tetrigidae) from China is reviewed. One species, spicupennis Zheng & Ou, 2003 (China: Yunnan) redescribed, and a new record of discalis (Hancock, 1915) given. An annotated identification key for Chinese species the provided. Mitochondrial genes S. were sequenced annotated. sizes two mitogenomes are 17,552 bp ( ), 16,069 respectively. All PCGs started with typical ATN (ATT, ATC or ATG) TTG codon most ended complete TAA TAG codon, exception ND5...