A5014614655- Hedgehog Signaling Pathway Studies
- Genetic and Kidney Cyst Diseases
- TGF-β signaling in diseases
- Epigenetics and DNA Methylation
- Biomedical Text Mining and Ontologies
- Microtubule and mitosis dynamics
- Connective Tissue Growth Factor Research
- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- Atrial Fibrillation Management and Outcomes
- CNS Lymphoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- Mobile Health and mHealth Applications
- Electronic Health Records Systems
- Histiocytic Disorders and Treatments
- Developmental Biology and Gene Regulation
- RNA Research and Splicing
- Plant Molecular Biology Research
- Cancer Genomics and Diagnostics
- NF-κB Signaling Pathways
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Fungal Infections and Studies
- Viral-associated cancers and disorders
- Genetic and rare skin diseases.
University at Buffalo, State University of New York
2013-2021
Hospital of the University of Pennsylvania
2017
University of California, Los Angeles
2009-2016
Buffalo General Medical Center
2015
Thomas Jefferson University
2009
University of Alabama at Birmingham
2003-2009
Matsumoto Dental University
2009
Asahi University
2009
Mizuho (Japan)
2009
Orthopaedic Hospital
2009
While cilia are present on most cells in the mammalian body, their functional importance has only recently been discovered. Cilia formation requires intraflagellar transport (IFT), and mutations disrupting IFT process result loss of mid-gestation lethality with developmental defects that include polydactyly abnormal neural tube patterning. The early mutants hindered research efforts to study role this organelle at later stages. Thus, investigate during limb development, we generated a...
Bone morphogenetic protein (BMP) signaling is required for endochondral bone formation. However, whether or not the effects of BMPs are mediated via canonical Smad pathways through noncanonical unknown. In this study we have determined role receptor Smads 1, 5 and 8 in chondrogenesis. Deletion individual results viable fertile mice. Combined loss 8, however, severe chondrodysplasia. Smad1/5(CKO) (cartilage-specific knockout) mutant mice nearly identical to Smad1/5(CKO);Smad8(-/-) mutants,...
The motor protein Kif3a and primary cilia regulate important developmental processes, but their roles in skeletogenesis remain ill-defined. Here we created mice deficient cartilage focused on the cranial base synchondroses. deficiency caused growth retardation dysmorphogenesis, which were evident neonatal animals by anatomical micro-computed tomography (μCT) inspection. also changed synchondrosis plate organization function, severity of these changes increased over time. By postnatal day...
TGFβs act through canonical and non-canonical pathways, signals are transduced via Smad2 Smad3. However, the contribution of vs. pathways in cartilage is unknown because role chondrogenesis has not been investigated vivo. Therefore, we analyzed mice which deleted (Smad2CKO), global Smad3-/- mutants, crosses these strains. Growth plates at birth from all mutant strains exhibited expanded columnar hypertrophic zones, linked to increased proliferation resting chondrocytes. Defects were more...
Background Nonvalvular atrial fibrillation (NVAF) affects almost 6 million Americans and is a major contributor to stroke but significantly undiagnosed undertreated despite explicit guidelines for oral anticoagulation. Objective The aim of this study investigate whether the use semisupervised natural language processing (NLP) electronic health record’s (EHR) free-text information combined with structured EHR data improves NVAF discovery treatment perhaps offers method prevent thousands...
Several workers have found that axonal microtubules a uniform polarity orientation. It is the "+" end of polymer distal to cell body. The experiments reported here investigate whether this high degree organization can be accounted for on basis structures or mechanisms within axon. Substantial depolymerization was observed in isolated, postganglionic sympathetic nerve fibers cat subjected cold treatment; generally less than 10% original number microtubules/micron 2 remained cross section....
Abstract One of the goals systems genetics is reconstruction gene networks that underlie key processes in development and disease. To identify cartilage play an important role bone development, we used a approach integrated microarray expression profiles from phenotypic data two sets recombinant inbred strains. Microarray generated isolated chondrocytes were to generate weighted coexpression networks. This analysis resulted identification subnetworks (modules) coexpressed genes then examined...
Primary cilia regulate several developmental processes and mediate hedgehog signaling. To study their roles in cranial base development, we created conditional mouse mutants deficient Polaris, a critical primary cilium component, cartilage. Mutant post-natal bases were deformed, synchondrosis growth plates disorganized. Expression of Indian hedgehog, Patched-1, collagen X, MMP-13 was reduced accompanied by decreases endochondral bone. Interestingly, there excessive intramembranous...
In a retrospective secondary-use EHR study identifying cohort of Non-Valvular Atrial Fibrillation (NVAF) patients, chart abstraction was done by two sets clinicians to create gold standard for risk measures CHA2DS2-VASc and HAS-BLED. Inter-rater reliability between each set NVAF the outcomes interest were variable, ranging from extremely low agreement high agreement. To assess process, focus group survey conducted. Survey findings revealed patterns difficulty in assessing certain items...
Langerhans cell neoplasm and B-cell lymphoma/leukemia are generally thought to be two different types of neoplasms derived from the dendritic/histiocytic lymphoid hematopoietic lineages, respectively. However, recent studies have shown that can transdifferentiated lymphoproliferative disorders. Nonetheless, …
Although the use of whole slide images (WSIs) in diagnostic pathology has been widely studied, its reliability assessing liver allograft biopsies not yet investigated.Due to time sensitive nature donor organ biopsies, WSIs may greatly facilitate speedy off-site evaluation.In this study, we examined accuracy and reproducibility diagnosis on made from by pathologists trained with glass slides.39 cases donors our institution past 10 years were included.WSIs using an Aperio ScanScope OS scanner....
BMI Investigator (BMII) is an interactive web-based tool with a learning knowledge base, which provides way for researchers to query structured, unstructured, genomic and image data contained in warehouse. We demonstrate how development of efficient, usable, learnable web interface diverse group research stakeholders benefits from iterative human-centered participatory design process utilizing team clinicians, students, programmers, informatics experts.
CD10+ nodal marginal zone lymphoma is very rare. There has been only one case reported in the English literature so far. Here we report a second of with strong CD10 expression. The …
<sec> <title>BACKGROUND</title> Nonvalvular atrial fibrillation (NVAF) affects almost 6 million Americans and is a major contributor to stroke but significantly undiagnosed undertreated despite explicit guidelines for oral anticoagulation. </sec> <title>OBJECTIVE</title> The aim of this study investigate whether the use semisupervised natural language processing (NLP) electronic health record’s (EHR) free-text information combined with structured EHR data improves NVAF discovery treatment...