A5004517630- Polyomavirus and related diseases
- Full-Duplex Wireless Communications
- RNA Interference and Gene Delivery
- Viral Infections and Immunology Research
- BRCA gene mutations in cancer
- DNA Repair Mechanisms
- Cytomegalovirus and herpesvirus research
- Carcinogens and Genotoxicity Assessment
- RNA Research and Splicing
- Neurogenetic and Muscular Disorders Research
- Amyotrophic Lateral Sclerosis Research
- Antenna Design and Analysis
- Cervical Cancer and HPV Research
- Genomics and Chromatin Dynamics
- Viral-associated cancers and disorders
- Genetics and Neurodevelopmental Disorders
- Gene expression and cancer classification
- Viral gastroenteritis research and epidemiology
- Epigenetics and DNA Methylation
- Energy Harvesting in Wireless Networks
- Retinoids in leukemia and cellular processes
- Slime Mold and Myxomycetes Research
- Biocrusts and Microbial Ecology
- Cell death mechanisms and regulation
- Molecular Biology Techniques and Applications
Eastern Virginia Medical School
2007-2020
Icahn School of Medicine at Mount Sinai
1989-2007
Wright State University
1995
Kettering Medical Center
1995
The single-stranded DNA- and RNA-binding protein, Purα, has been implicated in many biological processes, including control of transcription multiple genes, initiation DNA replication, RNA transport translation. Deletions the PURA gene are frequent acute myeloid leukemia. Mice with targeted disruption both alleles appear normal at birth, but 2 weeks age, they develop neurological problems manifest by severe tremor spontaneous seizures die 4 weeks. There severely lower numbers neurons regions...
JC virus (JCV) causes progressive multifocal leukoencephalopathy, a demyelinating disease in brains of individuals with AIDS. Previous work has shown that the Tat protein, encoded by human immunodeficiency type 1 (HIV-1), can interact cellular protein Purα to enhance both TAR-dependent HIV-1 transcription and JCV late gene transcription. been activate through interaction Purα, which binds promoter sequence elements near origin replication. DNA footprinting large T-antigen cooperatively at...
JC virus (JCV) is the etiological agent of an opportunistic brain infection, progressive multifocal leukoencephalopathy (PML), in AIDS. PML fatal approximately 4% HIV-infected individuals, and although overall incidence has fallen due to highly aggressive antiretroviral therapy (HAART), this percent remained steady. It been shown that Tat protein human immunodeficiency virus-1 (HIV-1) interacts cells with cellular Purα. This interaction can stimulate transcription both HIV-1 JCV genes....
Abstract Minichromosome maintenance (MCM) proteins are essential for DNA replication in eukaryotes. A subcomplex of the MCM2‐7 family members, initially characterized yeast, is thought to serve as a eukaryotic replicative helicase. MCM8 new member, not present which may function alone or with other members aspects metabolism, including initiation and elongation. Through use chromatin immunoprecipitation, we find that MCM8, like MCM7, colocalizes on specific segment c‐MYC zone ( replicator)...
We document a unique DNA recombination between polyomavirus JC (JC virus [JCV]) and Epstein-Barr (EBV) at sequences of JCV found infecting the brain. Archetype is present in bone marrow uroepithelial cells most adults. During immunosuppression, can infect brain, causing demyelinating disease, progressive multifocal leukoencephalopathy. Rearrangements archetype noncoding control region are necessary for neurovirulence. Two NCCR deletions duplication occur homology with EBV, latently B cells,...
Journal Article Selective initiation of replication at origin sequences the rDNA molecule Physarum polycephalum using synchronous plasmodial extracts Get access Dianne C. Daniel, Daniel Brookdale Center for Molecular Biology and Department Pathology, Mount Sinai School Medicine1 Gustave L.Levy Place, New York, NY 10029, USA Search other works by this author on: Oxford Academic PubMed Google Scholar Edward M. Johnson Nucleic Acids Research, Volume 17, Issue 20, 25 October 1989, Pages...
Progressive multifocal leukoencephalopathy is a neurodegenerative disease caused by demyelination in the brain. The due to infection of oligodendroglial cells polyomavirus JC, circular DNA virus. virus resides as an archetype form uroepithelial and bone marrow more than 70% adults, whom it seldom causes overt symptoms. JC viral infecting brain differs from archetype. This contains two deletions duplication non-coding control region that are thought be derived These rearrangements necessary...
The recent observation of interviral recombination between members two distinct classes DNA viruses has opened the gates to a new field human disease development. In all cases studied thus far is rare event that requires special circumstances for intracellular interaction participating viral genomes. rarity and requirements do not detract from potential clinical significance resulting recombinants, as exemplified by JC Epstein-Barr This depends largely upon mechanisms would generate specific...
JC virus (JCV) is the etiological agent of an opportunistic brain infection, progressive multifocal leukoencephalopathy (PML), in AIDS. PML fatal approximately 4% HIV-infected individuals, and although overall incidence has fallen due to highly aggressive antiretroviral therapy (HAART), this percent remained steady. It been shown that Tat protein human immunodeficiency virus-1 (HIV-1) interacts cells with cellular Purα. This interaction can stimulate transcription both HIV-1 JCV genes....