A5031750168- Pancreatic and Hepatic Oncology Research
- Malaria Research and Control
- Mosquito-borne diseases and control
- Myofascial pain diagnosis and treatment
- Body Contouring and Surgery
- Epilepsy research and treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Thermoregulation and physiological responses
- Lipid metabolism and disorders
- Macrophage Migration Inhibitory Factor
- Endoplasmic Reticulum Stress and Disease
- Neuroendocrine Tumor Research Advances
- Glycogen Storage Diseases and Myoclonus
- Circular RNAs in diseases
- Gastrointestinal disorders and treatments
- Phagocytosis and Immune Regulation
- Cancer Diagnosis and Treatment
- Food Security and Health in Diverse Populations
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pharmacological Effects and Toxicity Studies
- Renal cell carcinoma treatment
- Pancreatitis Pathology and Treatment
- Cancer Mechanisms and Therapy
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
New York University
2020-2024
George Washington University
2023-2024
George Washington University Hospital
2024
Memorial Sloan Kettering Cancer Center
2020-2023
University of North Carolina at Chapel Hill
2021
Columbia University Irving Medical Center
2021
Columbia University
2021
NYU Langone Health
2019
Abstract Bodies have continuous reticular networks, comprising collagens, elastin, glycosaminoglycans, and other extracellular matrix components, through all tissues organs. Fibrous coverings of nerves blood vessels create structural continuity beyond organ boundaries. We recently validated fluid flow human fibrous tissues, though whether these interstitial spaces are the body or discontinuous, confined within individual organs, remains unclear. Here we show evidence for using two...
Abstract Background Recent studies have suggested the important roles of CD47 and tumor-associated macrophages in prognosis immunotherapy various human malignancies. However, clinical significance expression CD163+ TAMs pancreatic neuroendocrine tumor (PanNET) remains unclear. Methods In this study, 47 well-differentiated PanNET resection specimens were collected. evaluated using immunohistochemistry correlated with clinicopathologic properties. Results Positive staining was seen all PanNETs...
To investigate the diagnostic potential of AEG-1 and GPC-3 in hepatocellular carcinoma (HCC).AEG-1 immunohistochemistry were performed on HCC, adjacent nontumor tissue (ANT), dysplastic nodules (DN).H score or HCC was significantly higher than ANT DN. In 92% 54% showed positivity, respectively. ANT, 16.2% 7.6% positive. staining mostly diffuse, whereas frequently focal staining. alone high sensitivity but low specificity accuracy. GPC-3, other hand, Combination both stains boosted...
Hypoglycemia, defined as a blood glucose < 2.2 mmol/L, is associated with death in pediatric cerebral malaria (CM). The optimal duration of monitoring CM unknown. We collected data from 1,674 hospitalized Malawian children to evaluate the association between hypoglycemia and or neurologic disability survivors. assessed routine periodic measurements glucose. Children at admission had 2.87-fold higher odds (95% CI: 1.35-6.09) and, if they survived, 3.21-fold greater 1.51-6.86) sequelae...
Abstract Background In children with cerebral malaria (CM) admission blood lactate has previously guided intravenous fluid therapy and been validated as a prognostic biomarker associated death. The usefulness of post-admission measurements in CM is less clear. strength association between neurological sequelae survivors, well the optimal duration to identify at higher risk adverse outcomes unknown. Methods A retrospective cohort study 1674 Malawian hospitalized from 2000 2018 who had every 6...
<b><i>Introduction:</i></b> Signet ring cells (SRCs) may be observed in carcinomas from multiple primary sites. Elucidating unknown primaries metastases with SRCs represents a diagnostic challenge. This study examined morphologic characteristics of adenocarcinomas stablished sites and described objective features, which can aid identifying the site origin. <b><i>Methods:</i></b> The series encompasses 257 cases gastroesophageal junction (GEJ,...
Multiple genome-wide association studies (GWAS) have identified SNPs in the 8q24 locus near TRIB1 that are significantly associated with plasma lipids and other markers of cardiometabolic health, prior revealed roles hepatic myeloid Trib1 lipid regulation atherosclerosis. The same additionally adiponectin levels humans, implicating adipocyte biology. Here, we hypothesize adipose tissue regulates adiponectin, lipids, metabolic health. We investigate phenotype adipocyte-specific knockout mice...
AbstractMorning Report is a time-honored tradition where physicians-in-training present cases to their colleagues and clinical experts collaboratively examine an interesting patient presentation. The Morning section seeks carry on this by presenting patient's chief concern story, inviting the reader develop differential diagnosis discover alongside authors of case. This report examines story 15-month-old with faltering growth short stature. Using questions, physical examination, testing,...
Multiple clinical trials evaluating therapies for cerebral malaria (CM) have failed to demonstrate improved outcomes. This may derive from inclusion of children at all risk levels, including those low mortality or neurologic morbidity, limiting power detect significant differences between intervention arms. One solution is enrichment, enrolling trial participants higher adverse We assessed if demographic, physical examination and point-of-care laboratory testing results in combination could...
Abstract Bodies have “reticular networks” comprising collagens, elastin, glycosaminoglycans, and other extracellular matrix components, that are continuous within around all organs. Fibrous tissue coverings of nerves blood vessels create structural continuity beyond organ boundaries. We recently described fluid flow through such human fibrous tissues. It remains unclear whether these interstitial spaces the body or discontinuous, confined individual investigated IS using two approaches....
In Kaduna State, Nigeria, Alive & Thrive implemented a multilevel, multicomponent intervention to engage fathers support dietary diversity among 6–23 month olds. The objectives of this implementation research were (1) examine the experiences community health extension workers (CHEWs) and religious leaders trained deliver intervention, (2) explore mothers' fathers' with components. After 12 months implementation, we conducted in-depth interviews CHEWs leaders, 16 separate focus group...
Abstract Background Admission blood lactate has previously guided therapy and is a valid estimator of prognosis in children with cerebral malaria (CM). Since bolus intravenous fluid administration to febrile coma signs hypovolemia (including high lactate) may be harmful, the use guide waned. Its utility as prognostic biomarker, either at admission or during hospitalization, remains unclear. Methods We performed retrospective cohort study 1674 Malawian CM hospitalized from 2000–2018 who had...
Abstract Multiple GWAS have identified SNPs in the 8q24 locus near TRIB1 gene that significantly associate with plasma lipids and coronary artery disease. While subsequent studies uncovered roles for hepatic myeloid Trib1 contributing to either or atherosclerosis, causal tissue these associations remains unclear. The same adiponectin levels humans as well, suggesting a role adipose tissue. Here, we report adipocyte-specific knockout mice (Trib1_ASKO) increased decreased cholesterol...