A5050305697- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Cerebrovascular and Carotid Artery Diseases
- Blood Pressure and Hypertension Studies
- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- Nutritional Studies and Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac Valve Diseases and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Menopause: Health Impacts and Treatments
- Cardiovascular Function and Risk Factors
- Phytoestrogen effects and research
- Diet and metabolism studies
- Inflammasome and immune disorders
- Cholesterol and Lipid Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Antioxidant Activity and Oxidative Stress
- Cancer, Lipids, and Metabolism
- Air Quality and Health Impacts
- Peripheral Artery Disease Management
- Medical Coding and Health Information
- Galectins and Cancer Biology
- Biomarkers in Disease Mechanisms
- Gout, Hyperuricemia, Uric Acid
Centro Cardiologico Monzino
2016-2025
Institute for Atherosclerosis Research
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2007-2021
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences
2017
University of Milan
2009
AimsAlthough well supported by postmortem studies, the reliability of carotid atherosclerosis as surrogate marker coronary has been put in doubt vivo studies showing a poor correlation between intima-media thickness (IMT) detected external ultrasound (ECU) and stenosis assessed quantitative angiography (QCA). In present study, we have investigated whether stronger two arteries can be obtained using homogeneous variables such IMT, ECU intravascular (IVUS), respectively.
Background: The lack of specific vaccines or drugs against coronavirus disease 2019 (COVID-19) warrants studies focusing on alternative clinical approaches to reduce the spread this pandemic disease. In study, we investigated whether anti-influenza vaccination plays a role in minimizing diffusion COVID-19 Italian population aged 65 and over. Methods: Four outcomes were used: severe acute respiratory syndrome 2 (SARS-CoV-2) seroprevalence, hospitalizations for symptoms, admissions intensive...
Background and aimsCarotid plaque size the mean common carotid intima-media thickness measured in plaque-free areas (PF CC-IMTmean) have been identified as predictors of vascular events (VEs), but their complementarity risk prediction stratification is still unresolved. The aim this study was to evaluate independence PF CC-IMTmean cardiovascular stratification.MethodsThe IMPROVE-study a European cohort (n = 3703), where largest detected whole tree indexed cIMTmax. also assessed. Hazard...
The risk of cardiovascular disease and atherosclerosis progression is significantly increased after menopause, probably due to the decrease estrogen levels. use hormone replacement therapy (HRT) for prevention in older postmenopausal failed meet expectations. Phytoestrogens may induce some improvements climacteric symptoms, but their effect on remains unclear. reduction cholesterol accumulation at cellular level should lead inhibition atherosclerotic process arterial wall. intracellular...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is one of the key regulators low-density lipoprotein cholesterol plasma levels. Circulating PCSK9, which differs between genders, represents a valid pharmacological target for preventing cardiovascular (CV) events. We aimed to investigate sex-related associations PCSK9 levels and biochemical anthropomorphic factors, familial personal morbidities, in large European cohort (n = 3673) men (47.9%) women (52.1%).Individuals (aged 54-79 years)...
Lecithin:cholesterol acyltransferase (LCAT) is the enzyme responsible for cholesterol esterification in plasma. LCAT a major factor HDL remodeling and metabolism, it has long been believed to play critical role macrophage reverse transport (RCT). The effect of on human atherogenesis still controversial. In present study, plasma concentration was measured all subjects (n = 540) not drug treatment at time enrollment multicenter, longitudinal, observational IMPROVE study. Mean maximum...
Background The association between elevated serum uric acid (SUA), cardiovascular disease (CVD) risk, and carotid atherosclerosis has long been explored, contrasting results have reported. Therefore, the role of SUA as an independent risk factor for vascular events (VEs) deserves further attention. We investigated relationship SUA, incident VEs, intima-media thickness (cIMT), cIMT progression in subjects at moderate-to-high CVD risk. Methods Results In IMPROVE (IMT-Progression Predictors...
Background/Objectives: Carotid intima-media thickness (CIMT) has long been used as an index of subclinical atherosclerosis, but its role a risk modifier in cardiovascular (CV) optimization recently questioned due to methodological problems, such lack protocol standardization and scanning difficulties. In this multicentre, longitudinal, observational study, we tested the predictive ability two new CIMT variables detectable with simplified, quick, easy-to-standardize protocol. Methods: was...
The purpose of this study was to evaluate the effects timing and extent smoking, type cigarettes, concomitant vascular risk factors (VRFs) on association between smoking carotid intima-media thickness (C-IMT) in a lipid clinic population.1804 patients (869 men, age 21 85 year) participated study. Smoking habits were recorded C-IMTs measured by B-mode ultrasound. associations C-IMT with status (never, former, current) cigarettes' content tar, nicotine, carbon monoxide (alone or combined...
Echolucency, a measure of plaque instability associated with increased cardiovascular risk, can be assessed in both the carotid and plaque-free common intima–media (IM) complex as gray-scale median (plaque-GSM IM-GSM, respectively). The impact specific vascular risk factors on these two phenotypes remains uncertain, including nature extent their influence. This study aims to seek determinants plaque-GSM IM-GSM. Plaque-GSM IM-GSM were measured subjects from IMPROVE cohort (aged 54–79, 46%...
The present study evaluated the risks and benefits of phytoestrogen treatment in healthy perimenopausal women relation to dynamics climacteric syndrome progression atherosclerosis. Study participants were treated with placebo or phytoestrogen-rich natural preparation Karinat based on grape (Vitis vinifera) seeds, green tea (Camellia sinensis) leaves, hop (Hunulus lupulus) cone powder garlic (Allium sativum) powder. was by Kupperman Index Utian Quality Life Scale. Atherosclerosis measuring...
Vessel Plus is an open acccess journal, which publishes articles related to vascular diseases, including acute respiratory distress syndrome, aneurysm, atherosclerosis, hypertension, stroke, peripheral or pulmonary etc.
(1) Background and purpose: circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) is one of the key regulators cholesterol metabolism. Despite this, its role as a player in atherosclerosis development still matter debate. Here, we investigated relationships between this protein several markers subclinical atherosclerosis. (2) Methods: IMPROVE study enrolled 3703 European subjects (54-79 years; 48% men; with ≥3 vascular risk factors), asymptomatic for cardiovascular diseases....
BackgroundThe Mediterranean Diet (MD) is a model of healthy eating contributing to favorable health status, but its clinical usefulness still debated. The aim this study was relate the adherence MD with incidence cardio/cerebro-vascular events (VEs) in north and south European participants IMPROVE study.MethodsIMPROVE an observational, longitudinal, prospective cohort involving 3703 individuals from five countries (Finland, Sweden, Netherlands, France Italy). end-point first combined event...
The impact of cholesteryl ester transfer protein (CETP) on atherosclerosis is highly debated. This study aimed to investigate the associations between plasma CETP or genotypes and carotid intima-media thickness (cIMT) influence high-density lipoprotein cholesterol (HDL-C) these associations. Plasma HDL-C concentrations were measured in 552 subjects free any pharmacological treatment from IMPROVE cohort, which includes 3711 European at high cardiovascular risk. single-nucleotide polymorphisms...