A5052704073- Cystic Fibrosis Research Advances
- Inhalation and Respiratory Drug Delivery
- Tracheal and airway disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Polysaccharides Composition and Applications
- Proteoglycans and glycosaminoglycans research
- Asthma and respiratory diseases
- Dysphagia Assessment and Management
- Tendon Structure and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Osteoarthritis Treatment and Mechanisms
- Respiratory Support and Mechanisms
- Proteins in Food Systems
- Rheology and Fluid Dynamics Studies
- Respiratory and Cough-Related Research
- Sinusitis and nasal conditions
- Blood groups and transfusion
- Medical Imaging and Pathology Studies
- Nasal Surgery and Airway Studies
- Temporomandibular Joint Disorders
- Iron Metabolism and Disorders
- Oral Health Pathology and Treatment
- Freezing and Crystallization Processes
- Obstructive Sleep Apnea Research
- Characterization and Applications of Magnetic Nanoparticles
University of Sheffield
2019
Laboratoire Rhéologie et Procédés
2014-2017
National Jewish Health
2017
University of Colorado Denver
2017
Centre National de la Recherche Scientifique
2014-2015
Université Grenoble Alpes
2015
Université Joseph Fourier
2012-2014
Institut polytechnique de Grenoble
2014
Bronchial diseases are characterised by the weak efficiency of mucus transport through lower airways, leading in some cases to muco-obstruction bronchi. It has been hypothesised that this loss clearance results from alterations rheology, which reflected sputum samples collected patients, making rheology a possible biophysical marker these and their evolution. However, previous rheological studies have focused on quasi-static viscoelastic (linear storage moduli) properties only, not...
Nasal irrigation is widely practiced in infants, but its execution varies greatly. Although a consensus on how to perform this procedure has been published, supporting experimental evidence lacking. In vitro investigations using anatomical models are promising first step toward clinical research. Quantitative, exploratory data pediatric nasal irrigation, obtained from pragmatic setup, needed. A previously validated upper airway model of 10-month-old infant was used and filled with...
ABSTRACT The chewing process transforms food into bolus for a safe swallow. It is known that humans adapt their behavior to product characteristics. This study aimed at identifying individual strategies of healthy consumers and determining the respective consequences on properties. For purpose, activity 50 subjects was recorded during consumption five model cheeses. Boluses were collected swallowing threshold rheological analyses. We found 30% showed only slight adaptation characteristics...
Viscosupplementaion by intra-articular injection of hyaluronic acid (HA) is a therapeutic modality for treating osteoarthritis the knee, hip and less frequently other joints. During viscosupplementation, it usual to inject drugs, without knowing whether this association may have deleterious effect thereon. The rheological properties viscosupplement are highly dependent on product [molecular weight × concentration] HA. Therefore, any reduction its viscoelastic related either decrease...
(1) Background: We have previously shown that sputum rheology can discriminate between patients with COPD and other muco-obstructive lung diseases, it is correlated mucin content eosinophilia. now hypothesize could be a more-accurate guide than clinical evaluation for the prescription of azithromycin to prevent exacerbations reduce exposure antibiotics; (2) Methods: "COPD CaRhe" multicentric, randomized, controlled trial comparing outcomes in two parallel arms (36 vs. 36 patients). Patients...
Intra-articular injections of hyaluronic acid (HA) are widely used in the treatment osteoarthritis. HA half-life varies between products which might explain differences effectiveness viscosupplements. Aim To compare resistance to degradation linear and cross-linked viscosupplements using a rheological model combining mechanical oxidative stresses, mimicking what happens inside joint following injection. Methods The properties 8 HAs were measured stress-imposed Rheometer DHR3. Strain sweeps...
Airway mucus works as a protective barrier in the human body, it entraps pathogens that will be later cleared from airways by ciliary transport or coughing, thus featuring rheological properties of highly stretchable gel. Nonetheless, study these physical well remains limited due to restricted and invasive access lungs bronchi retrieve poor repeatability inherent native samples. To overcome limits, we report on biobased synthetic prepared snail slime multibranched thiol cross-linker, which...
Pulmonary mucus serves as a crucial protective barrier in the respiratory tract, defending against pathogens and contributing to effective clearance mechanisms. In Muco Obstructive Diseases (MOPD), abnormal rheological properties lead highly viscous mucus, fostering chronic infections exacerbations. While prior research has linked viscoelasticity its mucin content, variability MOPD patients implies involvement of other factors. To isolate these effects, produced by epithelia reconstituted...
<b>Background:</b> Sputum rheology measures the visco-elastic and mechanical properties of airway secretions. Parameters include critical stress that quantifies force needed to make mucus flow thought be linked capacity for clearance. Little is known about reproducibility method across different specialist centres. <b>Aim:</b> To compare other standard rheological parameters observed in non-cystic fibrosis bronchiectasis (NCFB) severe asthma (SA) two clinical <b>Methods:</b> was collected...
<b>Background:</b> Our aim was to determine the variables influencing sputum rheology in patients with severe asthma, Chronic Obstructive Lung Disease (COPD) and non-CF bronchiectasis (NCFB) <b>Methods:</b> We performed a cross sectional prospective cohort study. Spontaneous collected from consecutive muco-obstructive lung diseases. Sputum assessed using Rheomuco® rheometer (Rheonova, Grenoble); elastic modulus G', viscous G'', critical stress threshold σc were recorded. Chest...
<b>Introduction:</b> Rheology can be a tool to diagnose COPD and assess the efficiency of treatments on market or in development, by evaluating consistency sputum. allows better understanding expectoration deficiencies patients with COPD. The study aims find out whether rheology used clinical context. <b>Material & Methods:</b> Rheomuco device was measure viscoelastic properties (NCT02682290) called "<b>Assessment Rheological Parameters Human Sputum</b>". Two are mainly extracted:...