A5027618740- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Pancreatic function and diabetes
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Diabetes Treatment and Management
- Breast Cancer Treatment Studies
- Milk Quality and Mastitis in Dairy Cows
- Advanced battery technologies research
- Disaster Management and Resilience
- DNA and Nucleic Acid Chemistry
- Reproductive Biology and Fertility
- Inflammatory Biomarkers in Disease Prognosis
- Diabetes and associated disorders
- Cancer Diagnosis and Treatment
- Drug-Induced Ocular Toxicity
- Reproductive Physiology in Livestock
- Korean Urban and Social Studies
- Coenzyme Q10 studies and effects
- Central Venous Catheters and Hemodialysis
- Mass Spectrometry Techniques and Applications
- Cholesterol and Lipid Metabolism
- Microbial Fuel Cells and Bioremediation
- Neuroscience and Neuropharmacology Research
- Cancer Risks and Factors
Jichi Medical University
2018-2025
Jichi Medical University Hospital
2023
Osaka City General Hospital
2017-2023
Gifu University
2014
Kyoto University
2009-2011
Nagoya University
2011
University of Saskatchewan
2007
Dalhousie University
2007
Kitasato University
2006
Tokyo Institute of Psychiatry
1991
Multiple bioactive peptides, including glucagon, glucagon-like peptide-1 (GLP-1), and GLP-2, are derived from the glucagon gene (Gcg). In present study, we disrupted Gcg by introduction of GFP cDNA established a knock-in mouse line. Gcg(gfp/gfp) mice that lack most, if not all, Gcg-derived peptides were born in an expected Mendelian ratio without gross abnormalities. showed lower blood glucose levels at 2 wk age, but those adult significantly different Gcg(+/+) Gcg(gfp/+) mice, even after...
Originally, apomorphine was a broad-spectrum dopamine agonist with an affinity for all subtypes of the Dopamine D1 receptor to D5 receptor. We previously identified as potential therapeutic agent mitochondrial diseases by screening chemical library fibroblasts from patients diseases. In this study, we showed that prevented ferroptosis in various types well normal controls. Well-known biomarkers include protein markers such prostaglandin endoperoxide synthase 2 (PTGS2), key gene...
Glucagon is believed to be one of the most important peptides for upregulating blood glucose levels. However, homozygous glucagon–green fluorescent protein (gfp) knock-in mice (Gcggfp/gfp: GCGKO) are normoglycemic despite absence proglucagon-derived peptides, including glucagon. To characterize metabolism in GCGKO mice, we analyzed gene expression and metabolome liver. The genes encoding rate-limiting enzymes gluconeogenesis was only marginally altered. On other hand, involved conversion...
To clarify the relationship between cellular immune status and nutritive condition in periparturient dairy cows, feeding content, blood profiles, were observed cows from two herds with different types of feed content. Immunological analyses such as leukocyte population peripheral mononuclear cell (PBMC) mRNA IFN-γ, TNF-α, IL-4, IL-10, quantified by real-time RT-PCR performed. With regard to content during dry periods, there six herd insufficient non-structural carbohydrate (NFC) intake...
Coenzyme Q10 (CoQ10) is involved in ATP production through electron transfer the mitochondrial respiratory chain complex. CoQ10 receives electrons from complex I and II to become reduced form, then transfers at III oxidized form. The redox state of has been reported be a marker metabolic state, but our knowledge, no reports have focused on individual quantification or ratio total (reduced/total CoQ10) patients with diseases. We measured skin fibroblasts 24 disease patients, including 5...
We observed single DNA molecules by fluorescence microscopy to clarify the effect of protamine on their higher-order structure. With an increase in concentration, conformation changes from elongated coil state a compact through intermediate state. Furthermore, long-axis length gradually decreases while maintaining distribution profile with peak. Such behavior is markedly different conformational transition induced small polyamines such as spermidine and spermine, where individual exhibit...
Therapeutic agents for dyslipidaemia, in particular statins, have been recently reported to suppress growth and metastasis of breast cancer. However, the predictive value lipid control cancer patients has not discussed sufficiently. In addition, though immunometabolism is a relatively novel approach tumour immunotherapy, relationship between metabolism immune status well documented. We therefore investigated effects on antitumour response prognosis.Except with ductal carcinoma situ, 938...
Functionalized (E)-vinylcopper species, selectively generated by the effective reduction of cyanoketene dithioacetals with two equimolar amounts cuprates, react electrophiles such as water, allyl bromide, and acid chlorides to give corresponding substitution products in good yields.
Nicotinamide adenine dinucleotide (NAD) is a critical cofactor in mitochondrial energy production. The NADH/NAD+ ratio, reflecting the balance between NADH (reduced) and NAD+ (oxidized), key marker for severity of diseases. We recently developed streamlined LC-MS/MS method precise measurement NAD+. Utilizing this technique, we quantified levels fibroblasts derived from pediatric patients Leigh syndrome mouse model which respiratory chain complex I subunit Ndufs4 knocked out (KO). In...
Neste material estão compiladas a tradução para o português do Manifesto por uma Etnografia de Retalhos e entrevista inédita realizada com duas suas autoras, Chika Watanabe Gökçe Günel. A aconteceu em julho 2022, através da plataforma Zoom, serviu conhecer os dilemas as perspectivas proposta etnografia defendida pelas pesquisadoras. O encontro também amparar refinar exercício que estava andamento, permitindo diálogo direto respeito abordagem retalhos identificação das formas pode ecoar na...
To clarify the utility of immunity profiling dairy herds, we analyzed peripheral mononuclear cells and performed blood metabolic A, B C herds. The occurrence peripaturient disease in Herd A was higher than it C. In biochemical analysis, high non-esterified fatty acid (NEFA) found before calving. herd B, levels total cholesterol glucose were compared with Herds immunological rates CD4+/CD8+ IFN-γ/IL-4 between one four months lower These findings suggested that there is suppression cellular...
HM32 Cognitive coping in young women with breast cancer R. Sachdev, S.M. Rosenberg, K.J. Ruddy, L. Schapira, S. Come, V. Borges, B. Larsen, Gelber, R.M. Tamimi, A.H. Partridge. Dana Farber Cancer Institute, Department of Medical Oncology, Boston MA, USA, Mayo Clinic, Rochester MN, Massachusetts General Hospital, Beth Israel Deaconess Center, University Colorado, Aurora CO, Biostatistics and Computational Biology, Brigham Women’s Channing Division Network Medicine, USA
BACKGROUND:Endogenous bacterial endophthalmitis is caused by a breach of the blood-ocular barrier pathogens originating from distant infective foci. Here, we report case endogenous due to cholangitis complicated common bile duct stones, which rare source infection. CASE REPORT:A 73-year-old man with type II diabetes mellitus underwent endoscopic choledocholithotripsy 20 years ago and laparoscopic cholecystectomy 18 ago. He had choledocholith-related 6, 5, 1 previously 4 times in last year...