Background: Appendicitis represents one of the most prevalent indications for emergency department care due to abdominal pain. Complications risk depends on how soon are diagnosed. Test like c-reactive protein (CRP) and neutrophil-lymphocyte index (NLI) can assist in diagnose complications, but they not always precise. Dipeptidyl peptidase 4 (DPP4) has been employed as a new marker other inflammatory pathologies; thus, exist potential its use pathologies such appendicitis. Evaluate utility...

Almost a year after the declaration of pandemic due to SARS-CoV-2 virus which causes COVID-19 disease and need contain progression treatment, promising option was designing an effective safe vaccine reach state massive immunity. The first approved one produced by Pfizer–BioNTech, its application started in December 2020. Within days applications, 0.2% adverse events were reported. Herein, series 26 cases with manifestation related dose BNT162b2 from Pfizer–BioNTech healthcare workers Mexico....

Transforming growth factor beta (TGF-β1) is a pleiotropic cytokine, which deregulated in atherosclerosis; however the role of age this process unknown. We aimed to assess whether TGF-β1 signaling affected by age.Vascular smooth muscle cells (VSMC) were obtained from patients undergoing abdominal surgery. Levels measured ELISA sera 169 coronary artery bypass grafting (CABG). The p27 expression was determined Western blot internal mammary arteries (IMA) CABG (n=13). In VSMC these surgery,...

Background and objectives: Dipeptidyl-Peptidase 4 (DPP-4) is a protein expressed in numerous cells tissues. Recently it has shown its involvement as catalyst the inflammatory response various pulmonary, autoimmune, intestinal other pathologies. The objective of this study was to compare preoperative serum levels DPP-4 patients with without surgical finding perivesicular inflammation. Materials methods: cross-sectional analytical nested prospective cohort, including scheduled for elective...

Background: Up to 30% of the population has sleep disturbances, generating a negative health impact, situation that is often not known and no medical attention sought. It been observed after total deprivation sleep, levels dipeptidyl peptidase 4 (DPP-4) tend increase. The aim this study was compare serum DPP-4 in healthy subjects, with adequate poor-quality needing medical/pharmacological treatment. Materials Methods: Cross-sectional subjects scheduled for elective surgery low...

Aim In patients with cardiovascular disease (CVD), the endothelial progenitor cells (EPCs) play a key role in repair processes. It has been hypothesized that Ets2 transcription factor could be involved instability of CVD/hyperlipidaemia. Recent studies have shown dipeptidyl peptidase‐4 (DPP‐4) is expressed on and appears to modulate their kinetics. Our main objective was determine degree expression factors Endoglin CXCR4 peripheral blood mononuclear from undergoing coronary artery‐bypass...

Background Decompensated heart failure is a common cause of hospitalization. Therapeutic use ARA‐II has demonstrated safety in this patients. Circulating drug concentrations can be affected by some factors (age, sex, body surface, formulation), and variations levels plasma observed, causing therapeutic therefore, greater hemodynamic instability. Aim To Identify that affect concentration (Losartan patent vs generic) its active metabolite (E‐3174) as well possible the patients with failure....

( Int J Gynaecol Obstet . 2021;153:483–488. doi: 10.1002/ijgo.13446) Severe postpartum hemorrhage (SPPH; blood loss ≥1500 mL in the 24 h following labor) can have serious adverse maternal outcomes. Thus, earlier diagnosis and management of (PPH) (defined as ≥500 during labor or ≥1000 cesarean delivery) is critical. Serum lactate has proven to more accurately predict severity mortality lead better decision making, ultimately improving The aim this study was assess relationship between serum...

Phenylephrine (PE)‐induced oscillatory fluctuations in intracellular Ca 2+ concentration ([Ca ] i ) of vascular smooth muscle (SM) have been observed every blood vessel isolated from a wide variety mammals. Paradoxically, until recently similar observations humans proven elusive. In this study, we report for the first time adrenergically‐stimulated [Ca oscillations human mesenteric artery SM. We partially characterized these by using inhibitory drugs nifedipine, 2‐aminoethoxydiphenyl borate...

In atherosclerotic patients undergoing coronary artery‐bypass grafting (CABG) it has been shown decreased numbers of endothelial progenitor CD144+ cells, compared to artery disease‐free valvular (1). At the same time, Ets‐2 is a transcription factor involved in differentiation and basic clinical models vascular remodelling. We aimed determine expression CD144 peripheral blood mononuclear cells from CABG patients, role inhibition on expression. was determined obtained 15 16 patients. silenced...

Cilostazol is an emerging vasodilatory drug which has been approved for the symptomatic treatment of intermittent claudication (CI). On other hand, a growing body evidence highlights importance endothelial progenitor cells in vascular repair. We aimed to study effect cilostazol on (EPCs) levels and clinical markers cohort 24 patients with CI at baseline after 6 months drug. EPCs were measured as CD34+/KDR+ CD34+/CD144+ mononuclear by flow cytometry. found that treated had increase from...

Editorial

Obesity prevalence in Mexico is higher than other countries (70%). Cross‐sectional studies with rotation shifts have observed that sleep disruption affects dietary intake and hormonal regulation (Adiponectin/Leptin/Ghrelin). Proposed mechanism an increase on expression of fatty acid transport molecules, which would induce weight gain adiposity, the risk developing obesity. Metabolomics analysis could help us to know if metabolic changes lipid products susceptibility contribute alterations...

Obesity is ones of the majors public health problems around world, according to World Health Organization, there were 1.9 billions adults with overweight or obesity. As we know, weight gain associated an increase in cardiovascular risk. The Atherogenic Index Plasma (AIP) log transformation ratio form triglycerides between HDL cholesterol serum. This a good measurement for risk, when result >0.5 risk diseases high. Until now metabolomics tool identify previous any diseases, like...

Background: Losartan, one of the most frequently used drugs in Heart Failure (HF) treatment, could be modified for its bioavailability (BA) by generic formulations and other factors. Hence, importance therapeutic drug monitoring. Objective: Development validation a simplified analytical method using HPLC simultaneous quantification losartan E-3174 human plasma samples. The was tested determining pharmacokinetics parameters HF patients. Methods: Analytical conditions were optimized C18 column...

Introduction 25% of maternal deaths worldwide are due to postpartum hemorrhage (PPH) 1 . Tissue hypoperfusion causes anaerobic respiration and lactic acid production. Lactate measurement has shown prognostic utility in different clinical conditions as severe sepsis polytrauma. Objective To Determine whether the concentration serum lactate measured at diagnosis indicates development hemorrhage. Material Methodology A cohort study was carried out including 30 patients vaginal labor cesarean...

Background It is estimated that up to 50% of all antibiotic’s prescription unnecessary or are not optimally effective. The World Health Organization (WHO) has proposed a broad antimicrobial stewardship programs (AMS) implementation in hospitals control and monitor antibiotics consumption the aim minimize resistance improve patient’s clinical outcome. AMS strategies involve providing prospective audits/feedback, formulary restriction, local education, implementing evidence‐based guidelines,...

In the health care process, trust placed by patients, caregivers, and support networks in healthcare provider plays an important role. This can be lost due to Conflicts of Interest (COI), which are described as conditions where primary objective professional (healthcare or scientific integrity) is altered a secondary objective, financial or not.